Comparative diagnostic value of 18F-fluoride PET-CT versus MRI for skull-base bone invasion in nasopharyngeal carcinoma

Le, Yali; Chen, Yu; Zhou, Fan; Liu, Guangfu; Huang, Zhanwen; Chen, Yue

doi:10.1097/mnm.0000000000000545

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…Although the reported false-positive rate of 18 F-NaF PET/CT is relatively high, our study demonstrated that the diagnostic accuracies of 18 F-NaF PET/CT are sufficiently high for detecting skull-base involvement in patients with NPC while compared with MRI. This finding is consistent with our previous study [ 22 ]. We consider that this finding may be related to the false-positive discoveries of MRI owing to common oedema and inflammation before and after radiotherapy.…”

Section: Discussionsupporting

confidence: 95%

Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Yin

Chen

Huang

et al. 2018

Contrast Media & Molecular Imaging

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Our study aimed at comparing the diagnostic value of 18F-NaF positron emission tomography-computed tomography (PET/CT) and 18F-fluorodeoxyglucose (FDG) PET/CT for detection of skull-base invasion and osseous metastases in patients with nasopharyngeal carcinoma (NPC). Our study retrospectively analyzed 45 patients with pathologically proven NPC. They all underwent both 18F-NaF PET/CT and 18F-FDG PET/CT within a 7-day interval. Bone metastases were confirmed by follow-up using PET/CT, enhance-contrast computed tomography (CT), and magnetic resonance image (MRI). These two examinations were compared using per-patient-based analysis and per-lesion-based analysis. 18F-NaF PET/CT detected 27 patients with skull-base invasion, whereas 18F-FDG PET/CT detected 17 patients. 18F-NaF PET/CT and 18F-FDG PET/CT differed significantly in diagnosing skull-base invasion (p=0.02) and sensitivity (p=0.008). The sensitivity, specificity, and agreement rate of 18F-NaF PET/CT for detecting bone metastatic lesions were 98.3%, 65.7%, and 92.9%, respectively; these values were 42.9%, 97.1%, and 51.9%, respectively, for 18F-FDG PET/CT. 18F-NaF PET/CT and 18F-FDG PET/CT differed significantly in the number of osseous metastases detected (t=2.45, p=0.18) sensitivity (p < 0.0001) and specificity (p=0.003). In patients with nasopharyngeal carcinoma, 18F-NaF PET/CT assessed invasion of the skull base better and detected more osseous metastases than 18F-FDG PET/CT.

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Section: Discussionsupporting

confidence: 95%

Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Yin

Chen

Huang

et al. 2018

Contrast Media & Molecular Imaging

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“…Furthermore, our study confirmed that compared with MRI, DECT demonstrated higher diagnostic sensitivity ( p < 0.001), specificity ( p < 0.001), and AUC (p = 0.028). Our results were in good agreement with several previous studies [ 41 , 42 ], in which DECT uses the rapid switching of high-tube and low-tube voltages to provide precisely registered high-energy and low-energy datasets for material decomposition, which may make it easier to identify subtle bone involvement in NPC. Thus, DECT could help reducing false-positive and false-negative rates and improving diagnostic performances of MRI for detecting skull base invasion in NPC, consistent with previous studies [ 24 , 41 ].…”

Section: Discussionsupporting

confidence: 92%

“…Additionally, Fig. 4 also showed one representative false-negative finding by MRI (one sclerotic lesion in the left pterygoid process was successfully recognized by SECT and DECT but undiagnosed by MRI), similar to a previous MRI study by Le et al [ 41 ]. Therefore, these false-positive and false-negative findings on MRI with regard to bone invasions were still a serious challenge, and a new, better diagnostic protocol needs to be explored in our study.…”

Section: Discussionsupporting

confidence: 83%

Dual-energy CT for the detection of skull base invasion in nasopharyngeal carcinoma: comparison of simulated single-energy CT and MRI

Zhan

Wang

et al. 2023

Insights Imaging

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Background Skull base invasion in nasopharyngeal carcinoma (NPC) was shown to be a poor negative prognostic factor, and dual-energy CT (DECT) has heralded a new approach to detect this condition. The study aims to evaluate the value of DECT for detection of skull base invasion in NPC and compare the diagnostic performance of DECT with those of simulated single-energy CT (SECT) and MRI. Methods The imaging findings of 50 NPC patients and 31 participants in control group which underwent DECT examinations were assessed in this retrospective study. The skull base invasions were evaluated using 5-point scale by two blind observers. ROC analysis, Mcnemar test, paired t test, weighted K statistics and intraclass correlation coefficient were performed to evaluate the diagnostic performance of simulated SECT, MRI and DECT. Results Quantitative analysis of DECT parameters showed higher normalized iodine concentration and effective atomic number values in sclerosis and lower values in erosion than those in normal bones (both p < 0.05). Compared with simulated SECT and MRI, the diagnostic sensitivity for DECT was significantly improved from 75% (simulated SECT) and 84.26% (MRI) to 90.74% (DECT) (both p < 0.001), specificity from 93.23% and 93.75% to 95.31 (both p < 0.001), accuracy from 86.67% and 90.33% to 93.67%, and AUC from 0.927 and 0.955 to 0.972 (both p < 0.05), respectively. Conclusions DECT demonstrates better diagnostic performance than simulated SECT and MRI for detecting skull base invasions in NPC, even those slight bone invasions in early stage, with higher sensitivity, specificity and accuracy. Graphical Abstract

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“…It can obtain tomographic images by reconstructing the sagittal plane, coronal plane, and any cut plane, to clearly show the internal and marginal situation of the organization and provide corresponding reference information for subsequent clinical diagnosis. Moreover, due to the fast scanning speed, it can perform quantitative scanning diagnosis of heart beat, coronary artery, and its branch calcification, which is a noninvasive examination method [9,10]. Magnetic resonance imaging (MRI) is a technique that adopts magnetic fields and radio wave energy pulses to image and inspect human internal organs and structures.…”

Section: Introductionmentioning

confidence: 99%

Image Fusion of Multislice Spiral CT with Magnetic Resonance Imaging (MRI) in the Diagnosis and Nursing of Malignant Bone Diseases Using ANOVA

Luo

Yang

Zhang³

et al. 2021

Scientific Programming

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This work aimed to analyze the diagnostic value of dynamic scanning of multislice spiral computed tomography (MSCT) and magnetic resonance imaging (MRI) for benign and malignant bone tumor and nursing intervention. 108 patients with bone tumor were selected as the research objects, all of which underwent MSCT and MRI scans. The accuracy, sensitivity, and specificity of MSCT, MRI, and MSCT + MRI for identifying benign and malignant bone tumors and nursing care were calculated, as well as the diagnostic accuracy of MSCT, MRI, and MSCT + MRI for different bone tumor pathological types. The results showed that the accuracy of MSCT + MRI (97.56%) in distinguishing benign and malignant bone lesions was remarkably higher relative to that of MSCT (85.91%) and MRI (89.85%) ( P < 0.05 ). The sensitivity and specificity of MSCT + MRI (94.85%; 90.52%) in distinguishing benign and malignant bone lesions were obviously greater in contrast to those of MSCT (83.66%; 79.05%) and MRI (86.02%; 81.17%) ( P < 0.05 ). The malignant misdiagnosis rate and malignant missing report rate of MSCT + MRI in distinguishing benign and malignant bone lesions were inferior to those of MSCT and MRI notably ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteosarcoma, giant-cell tumor of bone (GCT), bone cyst, and osteofibrous dysplasia (OFD) was evidently higher versus that of MSCT and MRI ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteofibroma and ganglioneuroma was greatly higher than that of MSCT and MRI ( P < 0.05 ). The accuracy of MSCT + MRI in distinguishing osteofibroma and ganglioneuroma was 68.64% and 71.63%, respectively. In short, in contrast to the single MSCT and MRI examination, MSCT combined with MRI detection can effectively improve the accuracy of judgment for benign and malignant bone tumor lesions and nursing care and had higher sensitivity and specificity. MSCT combined with MRI had better performance in identifying osteosarcoma, GCT, bone cyst, and OFD but poor performance in osteofibroma and ganglioneuroma.

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Comparative diagnostic value of 18F-fluoride PET-CT versus MRI for skull-base bone invasion in nasopharyngeal carcinoma

Cited by 7 publications

References 22 publications

Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Dual-energy CT for the detection of skull base invasion in nasopharyngeal carcinoma: comparison of simulated single-energy CT and MRI

Image Fusion of Multislice Spiral CT with Magnetic Resonance Imaging (MRI) in the Diagnosis and Nursing of Malignant Bone Diseases Using ANOVA

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Comparative diagnostic value of 18F-fluoride PET-CT versus MRI for skull-base bone invasion in nasopharyngeal carcinoma

Cited by 7 publications

References 22 publications

Comparison of 18F-NaF PET/CT and 18F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Comparison of 18F-NaF PET/CT and 18F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Dual-energy CT for the detection of skull base invasion in nasopharyngeal carcinoma: comparison of simulated single-energy CT and MRI

Image Fusion of Multislice Spiral CT with Magnetic Resonance Imaging (MRI) in the Diagnosis and Nursing of Malignant Bone Diseases Using ANOVA

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Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma