Comparison of <sup>18</sup>F-NaF PET/CT and <sup>18</sup>F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Yin, Zhan; Chen, Yue; Huang, Zhanwen; Zhang, Li; Wan, Qiang; Lei, Lei

doi:10.1155/2018/8271313

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…99m Tc-MDP is widely used to detect bone metastases. However, sodium fluoride-18 (NaF) PET combined with CT (NaF-PET/CT) has a higher sensitivity and specificity (42, 43). NaF-PET/CT ensures quick, bone-specific, blood clearance and efficient visualization of the axial skeleton.…”

Section: Overview Of Pca Imaging Methodsmentioning

confidence: 99%

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

et al. 2019

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Prostate cancer (PCa) is the main cause of cancer-related mortality in males and the diagnosis, treatment, and care of these patients places a great burden on healthcare systems globally. Clinically, PCa is highly heterogeneous, ranging from indolent tumors to highly aggressive disease. In many cases treatment—generally either radiotherapy (RT) or surgery—can be curative. Several key genetic and demographic factors such as age, family history, genetic susceptibility, and race are associated with a high incidence of PCa. While our understanding of PCa, which is mainly based on the tools of molecular biology—has improved dramatically in recent years, efforts to better understand this complex disease have led to the identification of a new type of PCa–oligometastatic PCa. Oligometastatic disease should be considered an individual, heterogeneous entity with distinct metastatic phenotypes and, consequently, wide prognostic variability. In general, patients with oligometastatic disease typically present less biologically aggressive tumors whose metastatic potential is more limited and which are slow-growing. These patients are good candidates for more aggressive treatment approaches. The main aim of the presented review was to evaluate the utility of liquid biopsy for diagnostic purposes in PCa and for use in monitoring disease progression and treatment response, particularly in patients with oligometastatic PCa. Liquid biopsies offer a rapid, non-invasive approach whose use t is expected to play an important role in routine clinical practice to benefit patients. However, more research is needed to resolve the many existing discrepancies with regard to the definition and isolation method for specific biomarkers, as well as the need to determine the most appropriate markers. Consequently, the current priority in this field is to standardize liquid biopsy-based techniques. This review will help to improve understanding of the biology of PCa, particularly the recently defined condition known as “oligometastatic PCa”. The presented review of the body of evidence suggests that additional research in molecular biology may help to establish novel treatments for oligometastatic PCa. In the near future, the treatment of PCa will require an interdisciplinary approach involving active cooperation among clinicians, physicians, and biologists.

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Section: Overview Of Pca Imaging Methodsmentioning

confidence: 99%

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

et al. 2019

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“…Zhang et al retrospectively analyzed 45 patients with pathologically proven NPC. The sensitivity, specificity, and agreement rate of 18 F-NaF PET/CT for detecting metastatic bone lesions were 98.3%, 65.7%, and 92.9%, respectively, and concluded that 18 F-NaF PET/CT outperforms 18 F-FDG PET/CT [ 18 ]. Also, the sensitivity and accuracy of 18 F-NaF PET/CT in this study are in line with the previous study [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Metastases between ¹⁸F‐NaF PET/CT, ¹⁸F‐NaF PET, and Planar ^99mTc‐MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma

Wang

Yang

Zeng

et al. 2022

Contrast Media & Molecular Imaging

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Purpose. Our study aims to compare the diagnostic value of 18F-NaF positron emission tomography-computed tomography (PET/CT), 18F-NaF PET, and planar 99mTc-MDP bone scintigraphy for detection of bone metastases in patients with newly diagnosed nasopharyngeal carcinoma (NPC). Methods. Our study retrospectively analyzed 58 patients with pathologically proven NPC. They all underwent both 18F-NaF PET/CT and planar 99mTc-MDP bone scintigraphy within a 7-day interval. Bone metastases were confirmed by follow-up using PET/CT, contrast-enhanced computed tomography (CT), and magnetic resonance imaging (MRI). These three examinations were compared using per-patient-based analysis and per-lesion-based analysis. Results. 19 patients (32.7%) were classified as having bone metastatic disease in their final diagnosis. The patient-based diagnostic performances (sensitivity, specificity, and overall accuracy) were as follows: 18F-NaF PET/CT (100%, 92.3%, and 94.8%), 18F-NaF PET (100%, 53.8%, and 69.0%), and planar 99mTc-MDP bone scintigraphy (78.9%, 74.4%, and 75.9%). The overall accuracy of 18F-NaF PET/CT was significantly more favorable compared to 18F-NaF PET ( p = 0.002 ) and to planar 99mTc-MDP bone scintigraphy ( p = 0.044 ). The lesion-based diagnostic performances (sensitivity, specificity, and overall accuracy) were as follows: 18F-NaF PET/CT (98.5%, 93.9%, and 96.6%), 18F-NaF PET (98.5%, 57.1%, and 81.1%), and planar 99mTc-MDP bone scintigraphy (69.9%, 85.7%, and 76.4%). Conclusion. 18F-NaF PET/CT outperforms 18F-NaF PET or planar 99mTc-MDP bone scintigraphy in detecting bone metastases with newly diagnosed NPC on a patient-based and lesion-based analysis.

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“…For detecting skull-base invasion, 18 F-NaF PET/CT had a sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 100%, 94.7%, 97.8%, 96.3%, and 100%, respectively, whereas for 18 F-FDG PET/CT these measures were 65.4%, 100%, 80%, 100%, and 67.9%, respectively. The sensitivity and specificity for detecting bone metastatic lesions were 98.3%, and 65.7%, respectively, for 18 F-NaF PET/CT and 42.9%, and 97.1%, respectively, for 18 F-FDG PET/CT (Table 2) (62).…”

Section: F-naf Versus F-fdgmentioning

confidence: 99%

¹⁸F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

Ahuja

Sotoudeh

Galgano

et al. 2019

J. Nucl. Med. Technol.

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Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Cited by 9 publications

References 27 publications

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

Comparison of Bone Metastases between ¹⁸F‐NaF PET/CT, ¹⁸F‐NaF PET, and Planar ^99mTc‐MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma

¹⁸F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

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Comparison of 18F-NaF PET/CT and 18F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Cited by 9 publications

References 27 publications

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

Liquid Biopsy in Oligometastatic Prostate Cancer—A Biologist's Point of View

Comparison of Bone Metastases between 18F‐NaF PET/CT, 18F‐NaF PET, and Planar 99mTc‐MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma

18F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

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Comparison of ¹⁸F-NaF PET/CT and ¹⁸F-FDG PET/CT for Detection of Skull-Base Invasion and Osseous Metastases in Nasopharyngeal Carcinoma

Comparison of Bone Metastases between ¹⁸F‐NaF PET/CT, ¹⁸F‐NaF PET, and Planar ^99mTc‐MDP Bone Scintigraphy in Patients with Newly Diagnosed Nasopharyngeal Carcinoma

¹⁸F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities