Comparative cytotoxic and biochemical effects of ligands and metal complexes of .alpha.-N-heterocyclic carboxaldehyde thiosemicarbazones

Saryan, Leon A.; Ankel, Else; Krishnamurti, Chitra; Petering, David H.; Elford, Howard L.

doi:10.1021/jm00196a013

Cited by 149 publications

(62 citation statements)

References 6 publications

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“…1), some of which are active as antitumor agents in animals but are not effective in humans (5). Studies on the Cu and Fe complexes of some ofthe active ligands show that the metal complexes are much more cytotoxic than the parent compounds (6).…”

Section: Mr + 02mentioning

confidence: 99%

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Antholine¹,

Kalyanaraman²,

Petering³

1985

Environmental Health Perspectives

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The relatively few iron and copper metal complexes which have been examined in cells and tissues for their redox properties, radical generation properties, and antitumor activity are discussed for studies which utilized electron spin resonance spectroscopy (ESR). A common property of a number of metal complexes, which include bleomycin, adriamycin, and thiosemicarbazones described in this review, is that they are readily reduced by thiol compounds and oxidized by oxygen or reduced species of oxygen to produce radicals. Structural features ofthese reactions are identified by ESR spectroscopy in model systems and-often in cells. Furthermore, ESR spectroscopy has been most useful to probe the environment of the complexes in cells and to measure the rate of reduction of their oxidized forms. As a result of these studies, it is anticipated that more attention will be given to the exploration of redox-active metal complexes as drugs.

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Section: Mr + 02mentioning

confidence: 99%

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Antholine¹,

Kalyanaraman²,

Petering³

1985

Environmental Health Perspectives

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“…They possess strong antineoplastic activity against a number of transplantable tumors, spontaneous murine tumors and human tumors. The mechanism of their antitumor action is thought to involve either inhibition of the enzyme ribonucleotide reductase, an obligatory enzyme in DNA synthesis [5][6][7], or creation of lesions in DNA strands [8]. The antifungal activity of Ni(II), Cu(II) and Zn(II) complexes with 5-nitro-2-furfural thiosemicarbazone has been demonstrated [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…2,7 ]tridecane-13-one (R = H, CH 3 , C 6 H 5 ). Characterization of the newly prepared complexes was accomplished by IR, UV-VIS and ESR spectroscopy, thermal analysis and molar electrical conductivity measurements.…”

Section: Introductionmentioning

confidence: 99%

Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Roșu

Gulea²,

Nicolae

et al. 2007

Molecules

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Abstract:The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-Rtricyclo [7.3.1.0. 2,7 ]tridecane-13-one (where R = H, CH 3 , C 6 H 5 ) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways -neutral bidentate or mononegative bidentate -depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand. The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.

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“…First row transition metal elements play important role in human life [1] and chemists are interested in co-ordination compounds for their application in industrial and synthetic processes, such as chemical, biological, environmental, ionexchange catalysis, photochemistry, and biological applications, Moreover their thermal, spectral, microscopic and many other properties have also been examined [2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Thermal Studies of Transition Metal Complexes with O-, S-Donor Ligands

Ramzan¹,

Saleem²,

Ali³

et al. 2017

JAPLR

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Transition metal carboxylates have been synthesized with transition metal chlorides of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Ru(III). The binding ligands are 3-[(4-bromophenylamido)]propenoic acid (L) and diethyl dithiocarbamate. All these compounds have been characterized by elemental analyses, conductivity measurements, UV/Vis, FT-IR spectroscopy and thermal analysis. Semi empirical studies of three compounds have also been carried out for structural elucidation showing that the Cr and Co derivatives have a six coordinated octahedral geometry which is in accordance with the data obtained from elemental analysis, UV/visible and FTIR spectroscopy. Thermal studies of all synthesized derivatives were carried out in a temperature range of 50-1000°C under inert atmosphere. Their kinetic parameters, like activation energy, enthalpy, entropy and order of reaction, were also studied. All complexes decompose at a certain temperature leaving behind metal oxides as residual products. The synthesized complexes showed remarkable anti-bacterial activities with a few exceptions. Selected compounds were also investigated for DNA damage assay.

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Comparative cytotoxic and biochemical effects of ligands and metal complexes of .alpha.-N-heterocyclic carboxaldehyde thiosemicarbazones

Cited by 149 publications

References 6 publications

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

ESR of Copper and Iron Complexes with Antitumor and Cytotoxic Properties

Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Synthesis, Characterization and Thermal Studies of Transition Metal Complexes with O-, S-Donor Ligands

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