A new series of transition metal complexes have been synthesized with [(2,3-dimethylphenyl)amino]benzoic acid (Mefenamic acid) in 1 : 1/1 : 2 M : L ratio. The complexes have been characterized by elemental analysis, FT-IR and UV-Vis spectroscopy. Antifungal, antibacterial, antitumor, antioxidant (DPPH, H 2 O 2 induced DNA damage) activity of the complexes and DNA interaction with the complexes were studied. The results revealed that the ligand and most of synthesized compounds did not demonstrate significant antibacterial activity unlike [Ni(Mef)(H 2 O)Cl] that exhibited pronounced activity against F. Solani. Antitumor activity of the products was higher than that of the free ligand.
Transition metal carboxylates have been synthesized with transition metal chlorides of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Ru(III). The binding ligands are 3-[(4-bromophenylamido)]propenoic acid (L) and diethyl dithiocarbamate. All these compounds have been characterized by elemental analyses, conductivity measurements, UV/Vis, FT-IR spectroscopy and thermal analysis. Semi empirical studies of three compounds have also been carried out for structural elucidation showing that the Cr and Co derivatives have a six coordinated octahedral geometry which is in accordance with the data obtained from elemental analysis, UV/visible and FTIR spectroscopy. Thermal studies of all synthesized derivatives were carried out in a temperature range of 50-1000°C under inert atmosphere. Their kinetic parameters, like activation energy, enthalpy, entropy and order of reaction, were also studied. All complexes decompose at a certain temperature leaving behind metal oxides as residual products. The synthesized complexes showed remarkable anti-bacterial activities with a few exceptions. Selected compounds were also investigated for DNA damage assay.
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