Comparative chemical composition, antioxidant and anticoagulant properties of phenolic fraction (a rich in non-acylated and acylated flavonoids and non-polar compounds) and non-polar fraction from Elaeagnus rhamnoides (L.) A. Nelson fruits

Olas, Beata; Żuchowski, Jerzy; Lis, Bernadetta; Skalski, Bartosz; Kontek, Bogdan; Grabarczyk, Łukasz; Stochmal, Anna

doi:10.1016/j.foodchem.2017.12.010

Cited by 37 publications

(42 citation statements)

References 33 publications

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“…However, part of the activities described in literature for plant extracts are attributed the antioxidant properties, also observed in the ethanolic extract of L. sidoides. [10] Due to their diverse health benefits, such as antioxidants, anticoagulants, immunomodulators, anti-inflammatory, and anticarcinogenic, [2,11,12] the phenolic compounds have been the focus of numerous researches, especially for the treatment and prevention of cancer, and reducing the risk of cardiovascular and inflammatory diseases.…”

Section: Resultsmentioning

confidence: 99%

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Braga

Abreu

Trento

et al. 2019

Chemistry & Biodiversity

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The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α‐glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α‐amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use.

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Section: Resultsmentioning

confidence: 99%

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Braga

Abreu

Trento

et al. 2019

Chemistry & Biodiversity

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“…The extracts from different parts of sea buckthorn (butanolic extracts from twigs and leaves and berries phenolic extract) protect cells against the effect of oxidizing factors, such as hydrogen peroxide (H 2 O 2 ) or H 2 O 2 /Fe. Moreover, it was shown that non-polar fraction containing triterpenes and their derivatives was more efficient in suppressing lipid peroxidation caused by H 2 O 2 /Fe than polar fraction rich in phenolic compounds (27,28). There is a link between the anti-inflammatory effects of sea buckthorn leaf extracts and a decrease Table 6.…”

Section: Fatty Acidsmentioning

confidence: 99%

“…The administration of a flavonoid-rich sea buckthorn fruit-based preparation also decreased platelet aggregation. The sea buckthorn preparations (different extracts) lengthened the blood clotting time, making it possible to conclude that such preparations will be beneficial in the treatment of thrombosis conditions (28,42). In addition, this formulation protects low-density cholesterol from oxidation, which can also have a positive effect when treating atherosclerosis and vascular thrombosis (42).…”

Section: Metabolism Regulation and Cardioprotective Propertiesmentioning

confidence: 99%

Composition and Biomedical Relevance of Sea Buckthorn

Jastrząb¹,

Skrzydlewska²

2019

Acta Poloniae Pharmaceutica - Drug Research

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Sea buckthorn (Hippophae rhamnoides L.; Elaeagnus rhamnoides (L.) A. Nelson) belongs to the Elaeagnaceae family, which naturally occurs in Asia, and Europe. There are seven basic species of sea buckthorn, but the exact number of subspecies is not specified. Depending on the climate, soil, and location, the different subspecies may differ in nutritional content (1-3). Sea buckthorn is a branched shrub or a small tree that is up to 3ñ4 meters tall with soaring, lanceshaped silverñgrey leaves. Ripe fruits (berries) of sea buckthorn are orangeñred. Inside the fruit, in addition to the soft inner tissue, there is a single dark brown seed in the central part of the fruit. All parts of the plant contain about 200 bioactive components, including flavonoids, phenolic compounds, tocopherols, fatty, and organic acids, fats, vitamins (A, E, K, C, B1, and B2), amino acids, terpenes, tannins, and macroelements (2). Leaves Sea buckthorn leaves contain many bioactive and nutritious compounds, including flavonoids, carotenoids, sterols, and triterpenes. Moreover, they are a rich source of potassium, magnesium, and calcium (4). The concentration of individual biologically active compounds in the organic extracts from sea buckthorn leaves depends on both the subspecies of sea buckthorn and the location of its occurrence (5-7). Due to their biological importance, phenolic compounds deserve special mention, especially such as myricetin or isorhamnetin (which have a total concentration ranging from 76.07 to 93.72 mg/g of dry material) as well as flavonoids (from 47.06 to 66.40 mg/g of dry matter). From the leaves of sea buckthorn, it is possible to obtain essential oils, which mainly consist of organic acids (constituting at least 36% of all compounds (Table 1) (8). Fruits, and seeds Like the sea buckthorn leaves, the fruits, and seeds have also been examined for their chemical compositions. They are characterized by a high content of phenolic compounds, fatty acids, tocopherols, and tocotrienols (Tables 2-5), whereas the level of individual components depends on the subspecies of sea buckthorn, and environmental factors such as the type of soil, climate, etc. The chemical compositions of sea buckthorn fruits and seeds are similar to those of the leaves.

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“…The search for agents that turn off the production of virulent factors or diminish their expression can bring about a new generation of species-specific anti-virulent drugs. In the case of SBT-products, they have applications in the supportive therapy of local skin lesions, mucosal infections and associated inflammatory symptoms in wound healing and other conditions [8,9,[11][12][13][14][15][16][17][18], directions that are in part reflected in the topics of ongoing clinical trials [10]. However, the sites of possible action of SBT-derived compounds in human body are the niches richly inhabited by many microorganisms constituting natural microbiota, which play a significant role in the host immune system [19][20].…”

Section: Direct Antimicrobial Activity Of Fractionated Sbt-extractsmentioning

confidence: 99%

Phenolic and Non-Polar Fractions of <em>Elaeagnus rhamnoides </em>(L.) A. Nelson Extracts as Virulence- Modulators - <em>In Vitro</em> Study on Bacteria, Fungi and Epithelial Cells

Różalska¹,

Sadowska²,

Żuchowski³

et al. 2018

Preprint

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Butanol extracts from leaves, twigs and fruits of Elaeagnus rhamnoides (L.) A. Nelson (sea buckthorn, SBT) were fractionated into phenolic and non-polar lipid components. Their chemical composition was analyzed using the Thermo Ultimate 3000RS chromatographic system, equipped with a diode array detector, a corona-charged aerosol detector, and coupled with a (Q-TOF) mass spectrometer. Assuming that an effect on natural microbiotaand host epithelial cells needs to be assessed, regardless of the purpose of using SBT formulations in vivo, the MIC/MBC/MFC of the fractions and reference phytocompounds were screened involving 17 species of Gram-positive and Gram-negative bacteria and Candida species. The impact of the fractions (subMIC) on the important in vivo persistence properties of S. aureus and C. albicans strains was evaluated. Tests for adhesion and biofilm formation on an abiotic surface and the surfaces conditioned with fibrinogen, collagen, plasma or artificial saliva showed the inhibitory activity of the fractions. The effects on FITC-labeled staphylococci adhesion to fibroblasts (HFF-1) and epithelial cells (Caco-2), and on fungal morphogenesis, indicated that SBT extracts have high anti-virulence potential. Cytotoxicity tests (MTT-reduction) on the standard fibroblast cell line showed variable biological safety of the fractions depending on their composition and concentration.

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Comparative chemical composition, antioxidant and anticoagulant properties of phenolic fraction (a rich in non-acylated and acylated flavonoids and non-polar compounds) and non-polar fraction from Elaeagnus rhamnoides (L.) A. Nelson fruits

Cited by 37 publications

References 33 publications

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Composition and Biomedical Relevance of Sea Buckthorn

Phenolic and Non-Polar Fractions of <em>Elaeagnus rhamnoides </em>(L.) A. Nelson Extracts as Virulence- Modulators - <em>In Vitro</em> Study on Bacteria, Fungi and Epithelial Cells

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