Comparative Bioactivity Study of 45S5 and 58S Bioglasses in Organic and Inorganic Environment

Theodorou, G.; Goudouri, Ourania-Menti; Kontonasaki, Eleana; Chatzistavrou, Xanthippi; Παπαδοπούλου, Λ.; Kantiranis, Nikolaos; Paraskevopoulos, K. M.

doi:10.4303/bda/d110154

Cited by 30 publications

(26 citation statements)

References 11 publications

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“…15,25,28,30 However, no systematic and insightful assessments have been performed yet to shed light on the complex processes involved and their causality.…”

Section: Discussionmentioning

confidence: 99%

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Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Popa¹,

Stan²,

Husanu³

et al. 2017

IJN

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Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid–implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials’ structure-dissolution behavior. This will contribute to “upgrade” our vision of entire cascades of events taking place at the implant surfaces upon immersion in the testing media or after implantation. Starting from an osteoinductive bioglass composition with the ability to alleviate the oxidative stress, thin bioglass films with different degrees of polymerization were deposited onto titanium substrates. Their biomineralization activity in simulated body fluid and in a series of new inorganic–organic media with increasing biomimicry that more closely simulated the human intercellular environment was compared. A comprehensive range of advanced characterization tools (scanning electron microscopy; grazing-incidence X-ray diffraction; Fourier-transform infrared, micro-Raman, energy-dispersive, X-ray photoelectron, and surface-enhanced laser desorption/ionization time-of-flight mass spectroscopies; and cytocompatibility assays using mesenchymal stem cells) were used. The information gathered is very useful to biologists, biophysicists, clinicians, and material scientists with special interest in teaching and research. By combining all the analyses, we propose herein a step forward toward establishing an improved unified protocol for testing the bioactivity of implant materials.

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“…15,25,28,30 However, no systematic and insightful assessments have been performed yet to shed light on the complex processes involved and their causality.…”

Section: Discussionmentioning

confidence: 99%

“…24 Similar yet incomplete questions have been raised by a small number of researchers. 14,15,[24][25][26][27][28][29][30] Our studies are among the pioneering works on complex biomimetic testing solutions containing organic/inorganic components. 31,32 The subject gained more traction after the interrogative work of two leading scientists.…”

mentioning

confidence: 99%

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Popa¹,

Stan²,

Husanu³

et al. 2017

IJN

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“…For this reason, we measured the release of calcium from GC8 particles for several days. Also, since the type of media can influence degradation rate of bioglasses/glass-ceramics, we used CCM and buffered MilliQ water [66–68]. Despite achieving a sustained release for several days, calcium release was slower in CCM.…”

Section: Discussionmentioning

confidence: 99%

“…Despite achieving a sustained release for several days, calcium release was slower in CCM. This slower release could be have been caused by the organic content of CCM, which has been reported to interfere in the degradation of bioglasses [68]. Alternatively, precipitation of a layer of calcium phosphate on the surface of the particle could also have contributed to the reduced release in CCM [69].…”

Section: Discussionmentioning

confidence: 99%

PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation

et al. 2018

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Increasing blood vessel formation in diseased tissues with poor vascularization is a current clinical challenge. Cell therapy using human mesenchymal stem cells has received considerable interest, but low cell survival has hampered its translation to the clinic. Bioglasses and glass-ceramics have been explored as therapeutic agents for stimulating angiogenesis in soft tissues, but these effects need further evaluation in vivo. By incorporating both human mesenchymal stem cells and glass-ceramic particles in an implantable hydrogel, this study provides insights into the vasculogenic potential in soft tissues of the combined strategies. Enhancement of vessel formation and maturation supports further investigation of this strategy.

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“…It is clear that the bioactivity of quenched samples increases and bioactivity of unquenched ones decreases when the concentration of BSA increases from 10 to 20, because the method of quenching affected the bioactivity of samples due to different porosity. Since the porosity of quenched bioactive glass-ceramics were higher than unquenched ones, the interaction between the quenched samples and BSA in higher concentration of Ringer's solution with BSA was higher than that between unquenched ones and BSA [39]. …”

Section: Xrd Analysismentioning

confidence: 93%

Quenched/unquenched nano bioactive glass-ceramics: Synthesis and in vitro bioactivity evaluation in Ringer’s solution with BSA

Nabian

Delavar

Rabiee

et al. 2013

CI&CEQ

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The paper reports the first attempt at the method of changing cooling treatment of synthesizing in order to investigate its effect on the physical properties of sol-gel derived nano-bioactive glass-ceramics in the system 58SiO 2 -33CaO--9P 2 O 5 (wt.%). We hypothesized that the method of cooling may affect the properties of nano-bioactive glass-ceramics. To test this hypothesis, two different methods of cooling treatment were applied after calcinations in the synthesis. Both quenched and unquenched nano-bioactive glass-ceramics were soaked in Ringer's solution with bovine serum albumin (BSA) for bioactivity evaluation. The obtained samples were analyzed for their composition, crystallinity and morphology using X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), surface electron microscopy (SEM) and transmission electron microscopy (TEM). The SEM images showed that the morphology of nano-bioactive glass-ceramics was completely changed by the quenching process. The results of in vitro bioactivity evaluation revealed that the unquenched sample attained faster apatite formation ability than the quenched sample. Other properties of these two morphologically different nano-bioactive glass-ceramics are discussed.

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Comparative Bioactivity Study of 45S5 and 58S Bioglasses in Organic and Inorganic Environment

Cited by 30 publications

References 11 publications

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

PEG hydrogel containing calcium-releasing particles and mesenchymal stromal cells promote vessel maturation

Quenched/unquenched nano bioactive glass-ceramics: Synthesis and in vitro bioactivity evaluation in Ringer’s solution with BSA

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