Comparative assessment of the expression of Muc 2, Muc 5AC, and Muc 6 in serrated neoplasms of the colon

Mikhaleva, L.M.; Vandysheva, R. A.; Shakhpazyan, Nikolay K.; Федоров, Е. Д.; Biryukov, A.E.; Midiber, Konstantin; Печникова, В. В.

doi:10.17116/patol20198102110

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…As for MVHP polyps, SSA/P immunohistochemically expresses MUC2, MUC5AC and MUC6 [84,96]. The role of MUC6 was evaluated in SSA/Ps lesions and is controversial [84].…”

Section: Molecular Features Of the Serrated Colorectal Precursor Lmentioning

confidence: 99%

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer

Palma

D’Argenio

Pol

et al. 2019

Cancers

139

102

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Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different subtypes that differ in their clinical and prognostic features. In the past decade, in addition to the conventional adenoma-carcinoma model, an alternative multistep mechanism of carcinogenesis, namely the “serrated pathway”, has been described. Approximately, 15 to 30% of all CRCs arise from neoplastic serrated polyps, a heterogeneous group of lesions that are histologically classified into three morphologic categories: hyperplastic polyps, sessile serrated adenomas/polyps, and the traditional serrated adenomas/polyps. Serrated polyps are characterized by genetic (BRAF or KRAS mutations) and epigenetic (CpG island methylator phenotype (CIMP)) alterations that cooperate to initiate and drive malignant transformation from normal colon mucosa to polyps, and then to CRC. The high heterogeneity of the serrated lesions renders their diagnostic and pathological interpretation difficult. Hence, novel genetic and epigenetic biomarkers are required for better classification and management of CRCs. To date, several molecular alterations have been associated with the serrated polyp-CRC sequence. In addition, the gut microbiota is emerging as a contributor to/modulator of the serrated pathway. This review summarizes the state of the art of the genetic, epigenetic and microbiota signatures associated with serrated CRCs, together with their clinical implications.

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“…As for MVHP polyps, SSA/P immunohistochemically expresses MUC2, MUC5AC and MUC6 [84,96]. The role of MUC6 was evaluated in SSA/Ps lesions and is controversial [84].…”

Section: Molecular Features Of the Serrated Colorectal Precursor Lmentioning

confidence: 99%

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer

Palma

D’Argenio

Pol

et al. 2019

Cancers

139

102

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“…This difference suggests there is a quantitative difference of MUC5AC expression among phenotypes, which may be more specific to SSLs. For example, Mikhaleva and colleagues report that MUC5AC expression is found intensely across the entire length of the crypt, while in HPs and TSAs expression is focal (57). Differences in MUC5AC expression between SSLs and other polyp types align with previous research on this topic.…”

Section: Discussionmentioning

confidence: 99%

Mucin 5AC is a sensitive surface marker for sessile serrated lesions: results from a systematic review and meta-analysis

Liu,

Sachar,

Popov

et al. 2024

Preprint

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Sessile serrated lesions (SSLs) are a class of colon polyps which are challenging to detect through current screening methods but are highly associated with colon cancer. We reasoned that a biomarker sensitive for SSLs would be clinically useful to improve detection. Recent endoscopic and histopathologic studies suggest that SSLs are associated with alterations in intestinal mucin expression but the frequency with which this occurs is not known. We performed a meta-analysis of available pathologic studies comparing mucin expression on SSLs to normal colonic mucosa, tubular adenomas (TAs), villous adenomas (VAs), traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). We searched Medline, Pubmed, and Embase and found 440 publications in this topic, and 18 total studies met inclusion. We found that MUC5AC expression was more common in SSLs compared to normal colonic mucosa (OR=82.9, p<0.01), TAs (OR=11, p<0.01), and TSAs (OR=3.6, p=0.04). We found no difference in MUC5AC expression between SSLs versus HPs (OR=2.1, p=0.09) and no difference in MUC5AC expression between left colon and right colon HPs, with an OR=1.8, p=0.23. We found that MUC5AC expression was found commonly on VAs, SSLs, and TSAs while the frequency on colon cancers declined. MUC5AC is also upregulated in inflammatory bowel disease and in response to intestinal infections. MUC5AC expression highlights the potential of mucins as sensitive biomarkers, though not specific to SSLs. Further research into the clinical utilization of MUC5AC could enhance SSL detection.

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“…It is promising to be regarded as a prognostic target for diagnosis and treatment in cancers, such as gastric cancer, lung cancer, ovarian cancer and cervical cancer [6][7][8][9][10]. Studies have shown that MUC members are widely expressed in gastrointestinal tumors and can serve as potential targets for their prognosis [11][12][13][14][15][16]. However, the epigenetic and biological functions of muc members in breast cancer have not been systematically studied.…”

Section: Introductionmentioning

confidence: 99%

Epigenetics and Prognostic Survival Analysis of Muc Gene Family in Breast Cancer Based on Bioinformatics Analysis

Yang¹,

Cao²,

Liang³

et al. 2021

Preprint

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Background: To explore the epigenetic and biological functions of muc members in breast cancer. Results: Mutation analysis showed that most of the muc members had missense mutations and the breast cancer patients with muc13 had a poor prognosis. Methylation analysis showed that the methylation expression of muc1, muc4, muc5AC and muc13 was related closely. The differentially expressed muc1, muc13 and muc15 had a poor prognosis and were related to immune infiltrating lymphocytes in breast cancer microenvironment. Conclusions: The epigenetic basis and biological functions of muc members are closely related to the occurrence and development of breast cancer.

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Comparative assessment of the expression of Muc 2, Muc 5AC, and Muc 6 in serrated neoplasms of the colon

Cited by 3 publications

References 21 publications

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer

The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer

Mucin 5AC is a sensitive surface marker for sessile serrated lesions: results from a systematic review and meta-analysis

Epigenetics and Prognostic Survival Analysis of Muc Gene Family in Breast Cancer Based on Bioinformatics Analysis

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