Epigenetics and Prognostic Survival Analysis of Muc Gene Family in Breast Cancer Based on Bioinformatics Analysis

Abstract

Background: To explore the epigenetic and biological functions of muc members in breast cancer. Results: Mutation analysis showed that most of the muc members had missense mutations and the breast cancer patients with muc13 had a poor prognosis. Methylation analysis showed that the methylation expression of muc1, muc4, muc5AC and muc13 was related closely. The differentially expressed muc1, muc13 and muc15 had a poor prognosis and were related to immune infiltrating lymphocytes in breast cancer microenvironment. Conclusions: The epigenetic basis and biological functions of muc members are closely related to the occurrence and development of breast cancer.