The patients with SE were identified to have endometrial dysfunction characterized by lower reception to steroid hormones, impairment in glycodelin secretion, retardation in the development of pinopods and in the phase of the menstrual cycle, and local immunity disorders. The above endometrial changes should be taken into account in the pregravid preparation of patients with CE.
The article contains a literature review of clinical cases describing sessile serrated adenomas in the appendix from 1998 to 2018. Currently, it is still diffi cult to assess the true incidence of this pathology due to the fact that in most cases serrated adenomas are accidental fi ndings diagnosed after removing an inflamed appendix, since often, at small sizes, they do not cause clinical symptoms, do not bother patients and are inaccessible for endoscopic examination (if located behind its orifi ce). In addition, we present 2 clinical cases of sessile serrated adenoma of the appendix in patients who were admitted to the City Clinical Hospital No. 31 of the Moscow City Health Department in 2018 due to acute appendicitis, with a clinical and morphological characteristic, including a molecular genetics study.
Objective: To study the features of the detection of Helicobacter pylori (Hp) in early gastric cancer (EGC) by means of Romanovsky-Giemsa stain (RG), immunohistochemical (IHC) study and real-time polymerase chain reaction (PCR). Method: The material for the study was fragments of the gastric mucosa with early cancer from 21 patients. 3 methods were used for the detection of Hp: RG staining, IGH study using Cell Marque rabbit polyclonal antibodies to Hp and real-time PCR using AmpliSens Hp kit. Results: In 66.5% of cases Hp were not detected by any of the methods of research, and in 33.5% -Hp were detected by at least one of the methods. In this case, Hp were detected in 29% of positive cases by all three methods; also in 29% of positive cases Hp were diagnosed only by PCR. In the remaining 42% of cases Hp were detected by two methods of three. The sensitivity of PCR is 86%, RG is 71.5%, in IHC it is 43%. The expressed dissemination of Hp (+++) was only 14% of all positive cases, in 86% cases -weak (+). Conclusion: Only in 1/3 of patients with EGC Hp was detected, and in 86% of them -weak dissemination Hp. At the same time, none of the using methods gave 100% sensitivity to Hp.The online version of the original article can be found at https://doi
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