Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis

França, Luíz Felipe de Carvalho; Silva, Felipe Rodolfo Pereira da; Lenardo, David Di; Alves, Even Herlany Pereira; Nascimento, Hélio Mateus Silva; Silva, Isabela Aparecida Tito da; Vasconcelos, Any Carolina Cardoso Guimarães; Vasconcelos, Daniel Fernando Pereira

doi:10.1016/j.archoralbio.2018.10.024

Cited by 18 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that AI is mediated by the effect of proinflammatory cytokines, such as interleukin (IL)-6, in turn stimulating production of hepcidin, resulting in a combination of decrease in erythrocyte survival, impaired production of erythrocytes and hypoferremia. 3,4 Based on the initial evidence gathered so far 5,9 and enhanced by the larger sample size of this study compared with previous studies, it is possible that the local and systemic inflammatory reactions elicited by presence of periodontitis act on the cascade leading to increased production of hepcidin and to reduced production and survival of erythrocytes. Initial evidence suggests that HB and HCT levels may further decrease short-term following intensive periodontal therapy, 21 in line with traumatic anemia following surgery.…”

Section: Discussionmentioning

confidence: 85%

“…20 A recent systematic review on erythrocyte parameters included nine studies with a total sample size of 342 periodontitis and 359 healthy patients. 9 The authors found reduced RBCs, HB, MCH, MCHC, HCT and packed cell volume in patients with periodontitis. In agreement with the above review, by investigating 471 patients ranging from AgP to CP to healthy, we found that patients with periodontitis had reduced HCT level.…”

Section: Discussionmentioning

confidence: 96%

“…Although the association between periodontitis and AI was already suggested several years ago, only a few studies have investigated it since . A recent systematic review on erythrocyte parameters included nine studies with a total sample size of 342 periodontitis and 359 healthy patients . The authors found reduced RBCs, HB, MCH, MCHC, HCT and packed cell volume in patients with periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported reductions in hemoglobin (HB) levels, mean corpuscular hemoglobin (MCH), circulating erythrocytes, and hematocrit (HCT) in both CP ‒ and AgP . A recent systematic review and meta‐analysis including data from 342 cases and 359 controls revealed a significant decrease in erythrocyte counts (RBCs), HCT, and HB in patients with CP when compared with healthy individuals . However, no specific comparisons between aggressive and CP have been published.…”

Section: Introductionmentioning

confidence: 99%

“…8 A recent systematic review and meta-analysis including data from 342 cases and 359 controls revealed a significant decrease in erythrocyte counts (RBCs), HCT, and HB in patients with CP when compared with healthy individuals. 9 However, no specific comparisons between aggressive and CP have been published. Severe periodontitis has also been associated with increases in platelet count, 10 possibly through a process of reactive thrombocytosis mediated by systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Anemia of inflammation associated with periodontitis: Analysis of two clinical studies

Nibali

Darbar

Rakmanee

et al. 2019

Journal of Periodontology

View full text Add to dashboard Cite

Background While leukocytosis is a common feature of severe periodontitis, a smaller amount of evidence has been produced on erythrocytes counts in periodontitis, suggesting a possible tendency to anemia. The aim of this study was to investigate the associations between periodontitis and circulating leukocytes, erythrocytes, and platelets. Methods The study included 471 patients with periodontitis (including aggressive periodontitis [AgP], and chronic periodontitis [CP]) and periodontal health. A separate sample of 333 patients from a previous study (127 AgP and 206 periodontally healthy) was used as replication. Periodontal clinical data were collected and a blood sample was obtained from each participant for hematological analysis of leukocytes, erythrocytes and platelets. Results Adjusted linear regression analyses revealed associations between periodontitis and total leukocytes counts (p < 0.001), neutrophil counts (P <0.001) and hematocrit (HCT) levels (P = 0.045). Sub‐analysis revealed no statistically significant differences between AgP and CP. Disease severity was correlated with total leukocyte and neutrophil counts and HCT (P <0.001, P <0.001 and P = 0.004, respectively). In the replication sample, adjusted linear regression analysis revealed associations between periodontitis and decreased hemoglobin (HB) (P = 0.009), mean corpuscular hemoglobin (MCH) (P = 0.023), and MCH concentration (P <0.001). A subset of patients included in these studies (14% to 15.7% of periodontitis versus 8.4% to 10.2% of healthy, respectively, in the two cohorts) were anemic based on the World Health Organization criteria. Conclusion This paper, reporting results of periodontal examination and blood sampling in over 800 patients, suggest that not just leukocytosis but also tendency to “anemia of inflammation” are typical features of periodontitis.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Anemia of inflammation associated with periodontitis: Analysis of two clinical studies

Nibali

Darbar

Rakmanee

et al. 2019

Journal of Periodontology

View full text Add to dashboard Cite

show abstract

Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

et al. 2020

View full text Add to dashboard Cite

Aim Assessment of the effect of nonsurgical periodontal therapy on haematological parameters in patients with grades B (BP) and C periodontitis (CP). Methods Eight BP and 46 CP patients received full-mouth periodontal debridement within 48 h, if positive for Aggregatibacter actinomycetemcomitans with adjunctive systemic antibiotics (4 BP, 17 CP). Clinical data were collected prior and 12 weeks after periodontal therapy. Blood was sampled prior to and 1 day as well as 6 and 12 weeks after the first SD visit. Erythrocyte count, haemoglobin value, haematocrit (HCT), mean erythrocyte volume (MCV), mean corpuscular haemoglobin (MCH), MCH concentration (MCHC), platelets (PLT) and heat shock protein 27 (Hsp27) were assessed. Results Both groups showed significant clinical improvement (p < 0.05). Using univariate analysis, MCV was noticeably lower in CP than BP at all examinations, HCT only at baseline. For CP, MCHC was noticeably higher 12 weeks after SD than at baseline and 1 day (p ≤ 0.005) and Hsp27 increased noticeably at 1 day (p < 0.05). Repeated measures analysis of variance revealed African origin to be associated with lower MCV and female sex with lower MCHC. Conclusion Based on multivariate analysis, periodontal diagnosis (BP/CP) was not associated with haematological parameters measured in this study or serum Hsp27. In CP, nonsurgical periodontal therapy improved MCHC 12 weeks after SD. Also in CP Hsp27 was increased 1 day after SD.

show abstract

Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

et al. 2020

View full text Add to dashboard Cite

Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: Results obtained from a meta-analysis

Cited by 18 publications

References 34 publications

Anemia of inflammation associated with periodontitis: Analysis of two clinical studies

Anemia of inflammation associated with periodontitis: Analysis of two clinical studies

Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

Contact Info

Product

Resources

About