Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

Chaushu, Liat; Tal, Haim; Sculean, Anton; Fernández-Tomé, Blanca; Chaushu, Gavriel

doi:10.1007/s00784-020-03318-0

Cited by 12 publications

(19 citation statements)

References 25 publications

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“…The recent animal study by Chaushu et al [ 38 ] found a correlation between peri-implant disease and alterations in complete blood count. Since ACD is considered to be mediated by cytokines that are produced as a consequence of the inflammatory process, we can hypothesize that peri-implant disease may affect blood count through a cytokine-mediated mechanism and speculate that a similar mechanism is plausible for other systemic conditions.…”

Section: Discussionmentioning

confidence: 99%

“…As it was discussed before, similar to periodontitis, peri-implantitis could be potentially correlated to systemic conditions regarding the onset mechanism and the immune response. In fact, a recent clinical trial on animals by Chaushu et al [ 38 ] found that the presence of experimental peri-implant lesions could actually determine an alteration in hematological parameters. The authors investigated the correlation between peri-implant disease and anemia of chronic disease (ACD), which is a decrease of haemoglobin associated with chronic inflammatory diseases, by assessing complete blood count dynamics in experimental peri-implantitis in dogs.…”

Section: The Impact Of Peri-implantitis On Systemic Conditionsmentioning

confidence: 99%

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The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

Radaelli

Alberti

Corbella

et al. 2021

International Journal of Dentistry

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While periodontitis has been proven to have an impact on systemic conditions, such as cardiovascular diseases, pregnancy complications, or poor glycemic control in diabetic patients, the influence of peri-implantitis on systemic health has not been adequately explored in the literature as yet. The existing evidence suggests that peri-implant lesions lead to more intense inflammatory response than periodontitis. Given the analogies between periodontal diseases and peri-implantitis, the aim of the present paper was to review the scientific evidence about the potential correlation between peri-implantitis and systemic diseases and conditions. Two clinical trials on animals reported that experimental peri-implantitis determined an alteration in hematological and biological parameters. One human study explored the risk indicators for cardiovascular diseases and found that patients with peri-implantitis had significantly higher levels of triglyceride, uric acid, and white blood cells and lower levels of vitamin D. It was described in the literature that periodontitis affects cardiovascular health through a number of mechanisms, including the increase in systemic mediators of inflammation, which also has a role in the worsening of glycemic control in diabetic patients. Similarly, peri-implantitis may influence the systemic status through inflammatory cytokines such as IL-1, IL-6, and IL-10 and matrix metalloproteinases. One microbiological mechanism, based on the systemic dissemination of periodontal bacteria, has been hypothesized for cardiovascular diseases and pregnancy complications. Again, it is plausible that the same could occur in peri-implantitis. In conclusion, only few studies explored the systemic impact of peri-implantitis. Although changes in hematological parameters, biochemical parameters, and inflammatory markers have been reported in peri-implantitis, further studies are needed to investigate this correlation.

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Section: Discussionmentioning

confidence: 99%

Section: The Impact Of Peri-implantitis On Systemic Conditionsmentioning

confidence: 99%

The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

Radaelli

Alberti

Corbella

et al. 2021

International Journal of Dentistry

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“…In a study of 30 male periodontal patients with HGB values below 15 g/dL, Agarwal et al [ 15 ] found that, 1 year after periodontal therapy, there was a significant increase in the HGB values (mean change +0.95 g/dL, p < 0.001) and the RBC values (mean change +0.22 10 6 µL, p < 0.001). In an in-vivo study of experimentally induced peri-implantitis in dogs, Chaushu et al showed that the induction of peri-implant disease caused a change in CBC values, which was corrected after surgical therapy [ 23 ]. Contrary to these findings, in a study of the effect of nonsurgical periodontal therapy on CBC parameters in 52 patients, whereas a clinical improvement in periodontal factors was noted, no significant changes in HGB or RBC counts were found [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Avishai

Rabinovich

Gilat

et al. 2021

Biology

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Sialolithiasis is a chronic disease in which a sialolith (salivary stone) causes recurrent inflammation of the affected salivary gland. Anemia of inflammation is a well-described pathology in which a chronic inflammatory disease leads to a reduction in the red blood cell count, hemoglobin and hematocrit values. In this retrospective cohort study, we aim to find whether removal of the sialolith and alleviation of the inflammation affect the complete blood count results. We examined data regarding forty-nine patients who underwent surgery for the removal of a submandibular gland sialolith using the duct-stretching technique. Complete blood counts two years before and after the surgical procedure were collected. The average pre-procedure and post-procedure values were calculated for each patient to establish the average blood profile. The pre- and post-procedure values were compared to evaluate the effect of the surgical treatment on the blood profile. We found that the average blood count values for patients with sialolithiasis were towards the lower end of the normal range. Post-surgery, a significant increase in hematocrit, hemoglobin and red blood cell count was observed, which was more pronounced in the older age group and in patients with co-morbidities. We conclude that sialolith removal surgery is associated with significant improvement in the complete blood count values, especially in the elderly and in patients and with co-morbidities. The speculated pathogenesis is relative anemia of inflammation.

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Section: Introductionmentioning

confidence: 99%

“…Recent animal studies have shown elevation of peripheral levels of pro-inflammatory biomarkers (e.g., total protein, albumin, and white blood cells [WBC]) after ligature-induced experimental peri-implantitis [ 7 8 ]. It is worth mentioning that the surgical treatment of experimental peri-implantitis by means of open flap debridement led to a reduction of these systemic inflammatory parameters, which reached similar values to baseline [ 7 8 ]. It could be hypothesized that similarly to periodontitis, the inflamed and ulcerated peri-implant pocket epithelium allows the entrance of locally produced inflammatory mediators (e.g., leukocytes and cytokines) into the bloodstream, evoking a systemic immune and acute inflammatory response that subsequently could interact with lipid metabolism, thereby elevating blood levels of total cholesterol and low-density lipoprotein (LDL) cholesterol, which in turn may increase the risk of atherosclerotic disease.…”

Section: Introductionmentioning

confidence: 99%

Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study

Blanco

Liñares

Dopico

et al. 2021

J Periodontal Implant Sci

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The aim of this study was to compare the inflammatory and lipid profile of patients with and without peri-implantitis. Methods: A cross-sectional biochemical study was carried out in which blood samples were collected from 16 patients with peri-implantitis and from 31 subjects with healthy implants. Clinical peri-implant parameters were obtained from all subjects. Levels of tumor necrosis factor-alpha and interleukin-10 (IL-10) were measured in serum. Lipid fractions, glucose and creatinine levels, and complete blood count were also assessed. Results: After controlling for a history of periodontitis, statistically significant differences between peri-implantitis patients and controls were found for total cholesterol (estimated adjusted mean difference, 76.4 mg/dL; 95% confidence interval [CI], 39.6, 113.2 mg/dL; P<0.001), low-density lipoprotein (LDL) cholesterol (estimated adjusted mean difference, 57.7 mg/dL; 95% CI, 23.8, 91.6 mg/dL; P<0.001), white blood cells (WBC) (estimated adjusted mean difference, 2.8×10 3 /μL; 95% CI, 1.6, 4.0×10 3 /μL; P<0.001) and IL-10 (estimated adjusted mean difference, −10.4 pg/mL; 95% CI, −15.8, −5.0 pg/mL; P<0.001). The periimplant probing pocket depth (PPD) was modestly positively correlated with total cholesterol (r=0.512; P<0.001), LDL cholesterol (r=0.463; P=0.001), and WBC (r=0.519; P<0.001). A moderate negative correlation was observed between IL-10 and PPD (r=0.609; P<0.001). Conclusions: Otherwise healthy individuals with peri-implantitis showed increased lowgrade systemic inflammation and dyslipidemia.

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Peri-implant disease affects systemic complete blood count values—an experimental in vivo study

Cited by 12 publications

References 25 publications

The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Peri-implantitis, systemic inflammation, and dyslipidemia: a cross-sectional biochemical study

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