The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

Radaelli, Katherine; Alberti, Alice; Corbella, Stefano; Francetti, Luca

doi:10.1155/2021/5536566

Cited by 16 publications

(20 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although an immune response against periodontal pathogens is usually found in periodontitis or implantitis, the constant invasion of periodontal pathogens impairs the host’s innate and acquired immunity resulting in periodontal tissue destruction, including alveolar bone [ 93 ]. Therefore, controlling infection, preventing tissue destruction by eliminating pathogens and biofilms from the tooth or implant surface, and reducing tissue invasion are the main objectives of periodontitis and peri-implantitis treatment [ 94 , 95 ]. Table 2 shows the perspectives of graphene materials in the management of periodontal disease regarding their antimicrobial activity, periodontal tissue, and bone regeneration.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

et al. 2022

View full text Add to dashboard Cite

Graphene is a single-layer two-dimensional carbon-based nanomaterial. It presents as a thin and strong material that has attracted many researchers’ attention. This study provides a concise review of the potential application of graphene materials in caries and periodontal disease management. Pristine or functionalized graphene and its derivatives exhibit favorable physicochemical, mechanical, and morphological properties applicable to biomedical applications. They can be activated and functionalized with metal and metal nanoparticles, polymers, and other small molecules to exhibit multi-differentiation activities, antimicrobial activities, and biocompatibility. They were investigated in preventive dentistry and regenerative dentistry. Graphene materials such as graphene oxide inhibit cariogenic microbes such as Streptococcus mutans. They also inhibit periodontal pathogens that are responsible for periodontitis and root canal infection. Graphene-fluorine promotes enamel and dentin mineralization. These materials were also broadly studied in regenerative dental research, such as dental hard and soft tissue regeneration, as well as periodontal tissue and bone regeneration. Graphene oxide-based materials, such as graphene oxide-fibroin, were reported as promising in tissue engineering for their biocompatibility, bioactivity, and ability to enhance cell proliferation properties in periodontal ligament stem cells. Laboratory research showed that graphene can be used exclusively or by incorporating it into existing dental materials. The success of laboratory studies can translate the application of graphene into clinical use.

show abstract

Section: Resultsmentioning

confidence: 99%

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Furthermore, patients may have dental implants and develop peri-implant mucositis and peri-implantitis, which may have systemic implications similar to periodontal diseases [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma

Zecha

Raber-Durlacher

Laheij

et al. 2022

Front. Oral. Health

View full text Add to dashboard Cite

IntroductionFebrile neutropenia (FN) is a potential life-threatening complication of myelosuppressive chemotherapy, particularly when induced by infection. There is evidence that FN can originate from the oral cavity, but its contribution to FN is largely understudied in patients treated for solid tumors. The aim of this study was to assess the prevalence of FN in these patients and to evaluate its relation with dental foci and oral mucositis.Material and MethodsA prospective longitudinal observational study was conducted. Patients diagnosed with solid tumors and lymphoma scheduled to be treated with myelosuppressive chemotherapy with an intermediate risk of developing FN were included. A pre-chemotherapy dental examination was performed and patients were followed during and after chemotherapy regimen. During subsequent hospital visits for chemotherapy administration, the oral cavity was inspected and oral mucositis (OM) was scored using the CTC-AE version 3.0. When patients presented with fever, a comprehensive full body examination including laboratory/microbiological/imaging investigation was performed.ResultsEighty-eight patients were included. Pre-chemotherapy, 39 patients (44.3%) were diagnosed with a dental focus. During chemotherapy, 46 patients developed OM (53.4%), of which 15 patients had a maximum score of grade II (ulcerative mucositis). Ten patients developed FN during the follow-up period. Patients with FN more often suffered from ulcerative OM compared to patients without FN; both FN and mucositis risk was associated with the myelotoxicity of chemotherapy. However, no relation could be established between the presence of dental foci prior to chemotherapy and the development of FN (p > 0.05).ConclusionA significant relation was identified between ulcerative OM and FN, but no robust conclusions could be drawn with respect to a relationship between the presence of dental foci and FN.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Biomaterial-associated infections show high infiltration and prolonged persistence of host immune cells, suggesting that these infections may be a more important inducer of inflammatory reactions [ 16 , 17 ]. Elevated secretions of inflammatory cytokines such as IL-1, IL-6, and IL-10 remain essential markers of implant-associated inflammatory events [ 18 ]. These dysregulations in the inflammatory cytokine expressions could be influenced by various factors such as the type of pathogens, inter-bacterial interactions, and the presence of implant material.…”

Section: Introductionmentioning

confidence: 99%

Bacterial-Specific Induction of Inflammatory Cytokines Significantly Decreases upon Dual Species Infections of Implant Materials with Periodontal Pathogens in a Mouse Model

et al. 2022

View full text Add to dashboard Cite

Cytokine profiles are often perturbed after infections of medical implants. With a non-invasive in vivo imaging system, we report in a mouse model that interferon expression after infection of subcutaneous implants with Streptococcus oralis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola (alone or as a combination) was species-specific, persisted longer in the presence of implants, and notably decreased upon dual species infections. This type I interferon expression disappeared within two weeks; however, histology of implant–tissue interface indicated high recruitment of immune cells even after three weeks. This was suggestive that biomaterial-associated infections could have prolonged effects, including the systemic stimulation of inflammatory cytokines. The present study investigated the systemic impact of this chronic peri-implant inflammation on the systemic expression of inflammatory cytokines (23) using a multiplex assay. Initially, the cytokine measurement in murine fibroblasts exposed to periodontal pathogens remained limited to the expression of five cytokines, namely, IL-6, G-CSF, CXCL-1/KC, MCP-1 (MCAF), and IL-12 (p40). The systemic determination of cytokines in mice increased to 19 cytokines (IL-1α, IL-2, IL-3, IL-5, IL-6, IL-9, IL-12 (p40), IL-12 (p70), IL-13, IL-17A, CCL-11/Eotaxin, G-CSF, IFN-γ, CXCL1/KC, MCP-1 (MCAF), MIP-1α/CCL3, MIP-1β/CCL4, CCL5/RANTES, and TNF-α). Systemic induction of cytokines was species-specific in the mouse model. The cytokine induction from infected implants differed significantly from sole tissue infections and sterile implants. Notably, systemic cytokine induction decreased after infections with dual species compared to single species infections. These findings describe the systemic effect of chronic peri-implant inflammation on the systemic induction of inflammatory cytokines, and this effect was strongly correlated to the type and composition of initial infection. Systemic modulations in cytokine expression upon dual species infections exhibit an exciting pattern that might explain the complications associated with biomaterial-related infection in patients. Moreover, these findings validate the requirement of multispecies infections for pre-clinical studies involving animal models.

show abstract

The Impact of Peri-Implantitis on Systemic Diseases and Conditions: A Review of the Literature

Cited by 16 publications

References 49 publications

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

In Vitro Studies of Graphene for Management of Dental Caries and Periodontal Disease: A Concise Review

The Potential Contribution of Dental Foci and Oral Mucositis to Febrile Neutropenia in Patients Treated With Myelosuppressive Chemotherapy for Solid Tumors and Lymphoma

Bacterial-Specific Induction of Inflammatory Cytokines Significantly Decreases upon Dual Species Infections of Implant Materials with Periodontal Pathogens in a Mouse Model

Contact Info

Product

Resources

About