Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

Eickholz, Peter; Schröder, Mario; Asendorf, Anne; Schacher, Beate; Oremek, G. M.; Kaiser, Frank J.; Wohlfeil, Martin; Nibali, Luigi

doi:10.1007/s00784-020-03292-7

Cited by 4 publications

(11 citation statements)

References 30 publications

(53 reference statements)

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“…In an in-vivo study of experimentally induced peri-implantitis in dogs, Chaushu et al showed that the induction of peri-implant disease caused a change in CBC values, which was corrected after surgical therapy [23]. Contrary to these findings, in a study of the effect of nonsurgical periodontal therapy on CBC parameters in 52 patients, whereas a clinical improvement in periodontal factors was noted, no significant changes in HGB or RBC counts were found [24].…”

Section: Discussionmentioning

confidence: 98%

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Avishai

Rabinovich

Gilat

et al. 2021

Biology

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Sialolithiasis is a chronic disease in which a sialolith (salivary stone) causes recurrent inflammation of the affected salivary gland. Anemia of inflammation is a well-described pathology in which a chronic inflammatory disease leads to a reduction in the red blood cell count, hemoglobin and hematocrit values. In this retrospective cohort study, we aim to find whether removal of the sialolith and alleviation of the inflammation affect the complete blood count results. We examined data regarding forty-nine patients who underwent surgery for the removal of a submandibular gland sialolith using the duct-stretching technique. Complete blood counts two years before and after the surgical procedure were collected. The average pre-procedure and post-procedure values were calculated for each patient to establish the average blood profile. The pre- and post-procedure values were compared to evaluate the effect of the surgical treatment on the blood profile. We found that the average blood count values for patients with sialolithiasis were towards the lower end of the normal range. Post-surgery, a significant increase in hematocrit, hemoglobin and red blood cell count was observed, which was more pronounced in the older age group and in patients with co-morbidities. We conclude that sialolith removal surgery is associated with significant improvement in the complete blood count values, especially in the elderly and in patients and with co-morbidities. The speculated pathogenesis is relative anemia of inflammation.

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Section: Discussionmentioning

confidence: 98%

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Avishai

Rabinovich

Gilat

et al. 2021

Biology

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“…This is the exploratory analysis of data of a prospective cohort study on the effect of SI on serum inflammatory parameters. An exploratory analysis of haematological parameters and heat shock protein 27 has been published recently [ 7 ]. Clinical examinations and therapy have been described in detail before [ 5 , 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…An exploratory analysis of haematological parameters and heat shock protein 27 has been published recently [ 7 ]. Clinical examinations and therapy have been described in detail before [ 5 , 7 ]. Thus, only a brief description is provided in the following.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the fact that only patients suffering from AgP or generalised severe ChP had been included originally, it was assumed that all missing teeth had been lost due to periodontitis with the exception of missing 3rd molars that were never considered as lost due to periodontal reasons. For each patient, the percentage of teeth indicating stage III (CAL-V ≥ 5 mm, PPD ≥ 6 mm, furcation involvement class II and III) was documented [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…AgP and periodontitis grade C exhibit more rapid progression. This may be due to a hyperinflammatory phenotype that also may result in a higher systemic inflammatory burden (i.e., serum C-reactive protein (CRP) and neutrophil elastase (NE)), as shown for AgP [ 4 , 5 , 6 , 7 ]. Frequent bacteraemia and the systemic spill of proinflammatory cytokines [ 4 ] from periodontal pockets result in the release of NE and acute-phase proteins (e.g., CRP).…”

Section: Introductionmentioning

confidence: 99%

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Effect of Subgingival Instrumentation on Neutrophil Elastase and C-Reactive Protein in Grade B and C Periodontitis: Exploratory Analysis of a Prospective Cohort Study

Eickholz

Asendorf

Schröder

et al. 2022

JCM

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Background: Assessment of the effect of subgingival instrumentation (SI) on systemic inflammation in periodontitis grades B (BP) and C (CP). Methods: In this prospective cohort study, eight BP and 46 CP patients received SI. Data were collected prior to and 12 weeks after SI. Blood was sampled prior to, one day, 6, and 12 weeks after SI. Neutrophil elastase (NE), C-reactive protein (CRP), leukocyte count, lipopolysaccharide binding protein, interleukin 6 (IL-6) and IL-8 were assessed. Results: Both groups showed significant clinical improvement. NE was lower in BP than CP at baseline and 1 day after SI, while CRP was lower in BP than CP at baseline (p < 0.05). NE and CRP had a peak 1 day after SI (p < 0.05). Between-subjects effects due to CP (p = 0.042) and PISA (p = 0.005) occurred. Within-subjects NE change was confirmed and modulated by grade (p = 0.017), smoking (p = 0.029), number of teeth (p = 0.033), and PISA (p = 0.002). For CRP between-subjects effects due to BMI (p = 0.008) were seen. Within-subjects PISA modulated the change of CRP over time (p = 0.017). Conclusions: In untreated CP, NE and CRP were higher than in BP. SI results in better PPD and PISA reduction in BP than CP. Trial registration: Deutsches Register Klinischer Studien DRKS00026952 28 October 2021 registered retrospectively.

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Long‐term prognosis of teeth with class III furcation involvement

Eickholz

Runschke

Dannewitz

et al. 2021

J Clinic Periodontology

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Objective Evaluation of survival of teeth with class III furcation involvement (FI) ≥5 years after active periodontal treatment (APT) and identification of prognostic factors. Methods All charts of patients who completed APT at the Department of Periodontology of Goethe‐University Frankfurt, Germany, beginning October 2004 were screened for teeth with class III FI. APT had to be accomplished for ≥5 years. Charts were analysed for data of class III FI teeth at baseline (T0), at accomplishment of APT (T1), and at the last supportive periodontal care (T2). Baseline radiographic bone loss (RBL) and treatment were assessed. Results One‐hundred and sixty patients (age: 54.4 ± 9.8 years; 82 females; 39 active smokers; 9 diabetics, 85 stage III, 75 stage IV, 59 grade B, 101 grade C) presented 265 teeth with class III FI. Ninety‐eight teeth (37%) were lost during 110, 78/137 (median, lower/upper quartile) months. Logistic mixed‐model regression and mixed Cox proportional hazard model associated adjunctive systemic antibiotics with fewer tooth loss (26% vs. 42%; p = .019/.004) and RBL (p = .014/.024) and mean probing pocket depth (PPD) at T1 (p < .001) with more tooth loss. Conclusions Subgingival instrumentation with adjunctive systemic antibiotics favours retention of class III furcation‐involved teeth. Baseline RBL and PPD at T1 deteriorate long‐term prognosis.

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Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis

Cited by 4 publications

References 30 publications

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Surgical Treatment of Sialolithiasis Leads to Improvement in the Complete Blood Count

Effect of Subgingival Instrumentation on Neutrophil Elastase and C-Reactive Protein in Grade B and C Periodontitis: Exploratory Analysis of a Prospective Cohort Study

Long‐term prognosis of teeth with class III furcation involvement

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