Comparative Analysis of Aqueous Humor Cytokine Levels Between Patients With Exudative Age-Related Macular Degeneration and Normal Controls

Dong, Ming; Woo, Se Joon; Kim, Hye-Jung; Lee, Cheolju; Park, Kyu Hyung

doi:10.1167/iovs.13-12730

Cited by 40 publications

(39 citation statements)

References 41 publications

(58 reference statements)

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“…Cha et al found that the pattern of cytokine expression in the aqueous humor of exudative AMD patients varies from that of normal control subjects, where exudative AMD eyes were found to have increased levels of insulin-like growth factor binding protein 2 (IGFBP-2) and insulin-like growth factor-1 (IGF-1), indicating that the altered expression of IGF-related molecules may be involved in the disease pathogenesis for exudative AMD (Cha et al, 2013). …”

Section: Biomarkers In Heritability and Geneticsmentioning

confidence: 99%

Risk factors and biomarkers of age-related macular degeneration

Lambert

Elshelmani

Singh

et al. 2016

Progress in Retinal and Eye Research

283

240

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A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings.

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Section: Biomarkers In Heritability and Geneticsmentioning

confidence: 99%

Risk factors and biomarkers of age-related macular degeneration

Lambert

Elshelmani

Singh

et al. 2016

Progress in Retinal and Eye Research

283

240

View full text Add to dashboard Cite

show abstract

“…65–70 Table 2 lists select cytokines with direct involvement in inflammatory cascades. Consistent with the systemic findings discussed above, IL-6, which has pro-angiogenic properties, has been found in higher concentrations in aqueous fluid of eye with neovascular AMD compared to controls.…”

Section: Inflammatory Cytokines In Amdmentioning

confidence: 99%

Inflammatory Mechanisms of Age-related Macular Degeneration

Knickelbein

Chan

Sen

et al. 2015

International Ophthalmology Clinics

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“…Therefore, the use of these systemic biomarkers to identify or characterize AMD patients seems to be limited. AMD characteristic cytokine levels have been detected in aqueous humor [12], but their collection requires an opening of the eye with all its potential risks.…”

Section: Introductionmentioning

confidence: 99%