Inflammatory Mechanisms of Age-related Macular Degeneration

Knickelbein, Jared E.; Chan, Chi‐Chao; Sen, H. Nida; Ferris, Frederick L.; Nussenblatt, Robert B.

doi:10.1097/iio.0000000000000073

Cited by 78 publications

(64 citation statements)

References 105 publications

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“…; Knickelbein et al. ) However, it is still unknown whether these cytokines play a role in the primary pathogenesis of AMD or represent a secondary result of the disease process. We investigated patients with mainly dry AMD and observed higher intraocular IL‐8 compared to cataract and RP.…”

Section: Discussionmentioning

confidence: 99%

Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age‐related macular degeneration, glaucoma and cataract

Berge

Fazil

Born

et al. 2018

Acta Ophthalmologica

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Purpose To analyse intraocular cytokine levels and prevalence of intraocular antiretinal antibodies (ARAs) in patients with retinitis pigmentosa (RP), age‐related macular degeneration (AMD), glaucoma and cataract, and correlate the results to clinical manifestations. Methods We collected intraocular fluid samples from patients with RP (n = 25), AMD (n = 12), glaucoma (n = 28) and cataract (n = 22), and serum samples paired with the intraocular fluids from patients with RP (N = 7) and cataract (n = 10). Interleukin (IL)‐1β, IL‐1ra, IL‐2, IL‐6, IL‐6rα, IL‐7, IL‐8, IL‐10, IL‐17A, IL‐23, thymus‐ and activation‐regulated chemokine (TARC), monocyte chemoattractant protein‐1 (MCP‐1), tumour necrosis factor‐alpha (TNF‐α), placental growth factor (PlGF) and vascular endothelial growth factor (VEGF) were measured using a multiplex assay. Antiretinal antibodies (ARA) detection was performed by indirect immunofluorescence. Results Increasing age was associated with increasing levels of IL‐6, IL‐8, TNF‐α and VEGF. All patient groups exhibited distinct profiles of intraocular cytokines. Intraocular levels of IL‐8 were highest in patients with AMD and glaucoma. Cataract patients exhibited high intraocular levels of IL‐23. Intraocular levels of IL‐2, IL‐6, MCP‐1 and PlGF in RP patients exceeded the levels of serum, indicating intraocular production. Intraocular ARAs were found in only one patient with AMD. Conclusion Increased levels of inflammatory cytokines in intraocular fluid of patients with originally noninflammatory ocular diseases show that intraocular inflammation is involved in their pathogenesis of these entities. Moreover, we show that increasing age is associated with increasing levels of intraocular cytokines and conclude that future studies on intraocular mediators should be corrected for age of patients.

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Section: Discussionmentioning

confidence: 99%

Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age‐related macular degeneration, glaucoma and cataract

Berge

Fazil

Born

et al. 2018

Acta Ophthalmologica

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“…Since PCV is mostly common in Asians, recent information supports the notion that angiogenesis and inflammation play an important and perhaps central role in the pathogenesis of nAMD and PCV [8]. There are some literatures on cytokines profile in aqueous humor of nAMD and PCV [9][10][11], but relatively few studies investigated the differences of both angiogenic and inflammatory cytokines in the aqueous humor among nAMD, PCV and controls. In the past, with the limitation of traditional ELISA consumables and aqueous humor contents, detecting the concentrations of cytokines in aqueous humor were restricted on a few selected cytokines [12,13].…”

Section: Introductionmentioning

confidence: 92%

Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients

et al. 2020

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Background: The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cytokine levels in the aqueous humor of eyes with PCV, nAMD and control. Methods: The present case control study included 49 treatment-naïve eyes from 49 patients (PCV 24, nAMD 11, and cataract 14 eyes). Totally 34 angiogenic and inflammatory cytokines in the aqueous humor were measured by Luminex bead-based multiplex array. Results: After adjusting for gender and age by multivariate logistic analysis, concentrations of IL-31, LIF, SDF1-α, VEGF-A, VEGF-D were significantly higher in eyes with nAMD or PCV compared with control eyes (all

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“…В то же время рядом авторов постулировано включение воспалительных механизмов в развитие ВМД [25,26]. Выявлено повышение уровня провос-палительных ЦК IL-6, 18, TNFα в плазме крови па-циентов; IL-2 и 17А -в ткани удаленной неоваску-лярной мембраны, IL-2, 6, 8, MCP-1 и ICAM-1 -во внутриглазных жидкостях пациентов с влажной ВМД [25,26].…”

Section: результаты и обсуждениеunclassified

Role of immunological factors in the development of myopic choroidal neovascularization

Щуко¹,

Zaytseva

Yureva

et al. 2016

Vestn. oftal'mol.

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Inflammatory Mechanisms of Age-related Macular Degeneration

Cited by 78 publications

References 105 publications

Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age‐related macular degeneration, glaucoma and cataract

Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa, age‐related macular degeneration, glaucoma and cataract

Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients

Role of immunological factors in the development of myopic choroidal neovascularization

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