2020
DOI: 10.1590/s2175-97902019000317808
|View full text |Cite
|
Sign up to set email alerts
|

Comparative analyses of response surface methodology and artificial neural networks on incorporating tetracaine into liposomes

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
9
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
5
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 8 publications
(9 citation statements)
references
References 37 publications
0
9
0
Order By: Relevance
“…Moreover, inclusion of tetracaine in the CP-TRANS nanoparticles induced a variation in the observed lamellar structure, since the 1 0-plane spacing (d10) diminished from 259 Å in CP-TRANS, to 230 Å in CP-TRANS/TTC. Such reduction in the lamellar interplanar distances (d10) suggests that tetracaine interacts with the CP molecules, decreasing the thickness or the lamellae by promoting lateral expansion, a phenomenon already observed for TTC in monolayers and bilayers 55 , 56 . TTC really causes dynamic rearrangements in lamellar phases, as recently demonstrated by Hu et al in dioleylphosphatidylcholine supported bilayers, increasing the lipid chain mobility and even inducing the formation of curved tubular structures prior to membrane disruption, at high TTC:lipid ratios 57 .…”
Section: Resultsmentioning
confidence: 66%
“…Moreover, inclusion of tetracaine in the CP-TRANS nanoparticles induced a variation in the observed lamellar structure, since the 1 0-plane spacing (d10) diminished from 259 Å in CP-TRANS, to 230 Å in CP-TRANS/TTC. Such reduction in the lamellar interplanar distances (d10) suggests that tetracaine interacts with the CP molecules, decreasing the thickness or the lamellae by promoting lateral expansion, a phenomenon already observed for TTC in monolayers and bilayers 55 , 56 . TTC really causes dynamic rearrangements in lamellar phases, as recently demonstrated by Hu et al in dioleylphosphatidylcholine supported bilayers, increasing the lipid chain mobility and even inducing the formation of curved tubular structures prior to membrane disruption, at high TTC:lipid ratios 57 .…”
Section: Resultsmentioning
confidence: 66%
“…ANN is an alternative better than the methods based on RSM in the case of performance. Furthermore, ANN can increase the level of certainty associated with the results and simultaneously can be used to validate new technological strategies [35]. Therefore, using RSM-ANN modeling, the shortcomings of RSM can be resolved and the actual relationship between independent and response parameters can be studied through experimental data [40].…”
Section: Comparative Evaluation Of Rsm and Annmentioning
confidence: 99%
“…There have been many works in the literature about the catalytic combustion, however, there have been fewer studies about the different mathematical modeling approaches and comparative analyzes. The mathematical modeling studies World Journal of Engineering and Technology are necessary to understand the process and show the optimization alternatives to the process [35].…”
Section: Introductionmentioning
confidence: 99%
“…Artificial intelligence (AI) based on machine learning (ML) has been increasingly used in different areas of knowledge. For example, ML techniques and algorithms allow a new analysis alternative and have accelerated discoveries of materials and formulations in the pharmaceutical field [37][38][39][40][41][42][43][44][45][46][47].…”
Section: Introductionmentioning
confidence: 99%