Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4

Abstract

Background. Bronchial asthma is one of the world's most common chronic disorders dangerous to human health. It has been hypothesized that the increased number of asthma sufferers may be due to changing antioxidant intake or vitamin deficiency. However, the influence of vitamins on asthma has rarely been considered. Objectives. The aim of this study was to explore the effects of γ-tocopherols, a specific form of vitamin E, on asthma remission together with the possible mechanism behind the process. Material and Methods. Eosinophil counting was applied to detect the total number of cells, eosinophils and lymphocytes. Meanwhile, HE staining was used for morphological detection. In addition, the eotaxin and IL-4 levels in the serum and bronchoalveolar lavage fluid were measured using ELISA technology. Results. The cell counting results showed that γ-tocopherols possesses the capability to reduce the number of eosinophils. Moreover, the exudation of inflammatory cells together with the hyperplasia of goblet cells was also found to experience significant inhibition when treated with γ-tocopherols. Furthermore, the high levels of eotaxin and IL-4 in the asthma group were evidently reduced under the treatment of γ-tocopherols which was comparable with hexadecadrol. Conclusions. γ-tocopherols can remit asthma by regulating the level of eotaxin and IL-4. Moreover, γ-tocopherols may be regarded as a potential candidate for asthma treatment after much deeper explorations (Adv Clin Exp Med 2016, 25, 4, 643-648).

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

“…In agreement with our findings Ma et al [34], Wu et al [22] and Malmström et al [35] who found significantly higher peripheral eosinophil counts in asthmatic group. Also, Chen et al [27] reported that there were statistically significant increase in the numbers of total leukocytes, lymphocytes, monocytes, eosinophils and basophils in the asthmatic group in comparison to control one.…”

“…Our results confirmed significantly higher serum IL-4 levels in atopic asthmatic children as compared to controls. Supporting our findings, Bao et al [20], Shi et al [21], Wu et al, [22] and Nesi et al [23] revealed a significant increase in IL-4 in ovalbumininduced asthmatic mice compared to the control. Our finding may also be reinforced in the light of observations of Antczak et al [5] who found higher mRNA level of IL-4 and IL-13 genes in asthmatic patients when compared to controls.…”

A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke–induced neutrophilic and eosinophilic airway inflammation

“… 24 Others have reported that γT dosing inhibits allergen-induced eosinophils in the airway, serum eotaxin, and IL-4. 25 …”