Comorbidity of migraine with ADHD in adults

Hansen, Thomas Folkmann; Hoeffding, Louise K.; Kogelman, Lisette J. A.; Haspang, Thilde Marie; Ullum, Henrik; Sørensen, Erik; Erikstrup, Christian; Pedersen, Ole Birger; Nielsen, Kaspar René; Hjalgrim, Henrik; Paarup, Helene M.; Werge, Thomas; Burgdorf, Kristoffer Sølvsten

doi:10.1186/s12883-018-1149-6

Cited by 28 publications

(40 citation statements)

References 40 publications

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“…Interestingly, ADHD is a disorder more commonly found in males [38] and migraine is more commonly found in females [22]. Meanwhile, some studies on adult populations have found that this co-morbidity increases with age and was more common in females [27]. In the current study we found that a significantly higher proportion of children with migraine were females and they had a higher mean age, compared to those without migraine in keeping with the existing findings.…”

Section: Discussionsupporting

confidence: 90%

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Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

2020

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Background: Headache and Attention Deficit Hyperactivity Disorder (ADHD) are two relatively common, neuropsychiatric conditions seen in children. Recent studies have shown an association between these two disorders, which are otherwise distinct conditions. This study aims to assess the association between migraine and ADHD, as well as the association between screen-time and these two conditions, among children attending a Sri Lankan tertiary care facility. Possible associations will have important implications in the clinical management of these conditions. Methods: This was a comparative cross-sectional study of 226 children aged 5-14 years, attending clinics at a tertiary care hospital in Galle, Sri Lanka. Of them, 141 had a diagnosis of migraine and 85 did not have migraine. The presence or absence of ADHD and the use of screen-time among the two groups was analysed. Chi-square test and Mann-Whitney U test was used to assess the associations between these variables. Results: Approximately 5% of the children with migraine had clinically diagnosed ADHD, compared to 3.5% of those without migraine (p = 0.862). The median SNAP-IV scores (inter-quartile range) of the children with migraine and without migraine were 0.60 (0.27-1.00) and 0.44 (0.16-0.80) respectively (p = 0.014). There was no significant difference in screen-time hours per day between children with and without clinically diagnosed ADHD. However, a significant difference in median screen-time (hours per day) was observed between children with and without migraine (2.0 h and 1.0 h respectively; p = 0.012). Conclusions: Our findings suggest that children with migraine are more likely to show features of hyperactivity/ impulsivity and inattentiveness than those without migraine. While no association was found between clinically diagnosed ADHD and screen-time, migraine was associated with longer daily screen use. Screening for ADHD in children diagnosed with migraine may be of benefit. Further studies are required to understand the possible benefits of reducing screen-time in children with migraine.

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Section: Discussionsupporting

confidence: 90%

“…Several recent studies have indicated a positive relationship between ADHD and migraine, in both children and adults [13,[24][25][26][27][28][29]. A recent meta-analysis reported a positive association between these two conditions [24].…”

Section: Introductionmentioning

confidence: 99%

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

2020

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“…Our results suggest that attentional difficulties are not only detected by fine electrophysiology measures in experimental sets-up, but are consciously experienced by migraineurs in daily life, even in patients with episodic migraine. This result is also congruent with a comorbidity reported between Attention Deficit and Hyperactivity Disorder (ADHD) and migraine (see (32) for a review and meta-analysis), in particular migraine with aura (33). Recently, a cross-sectional study among university students showed an association between self-perceived attention difficulties and hyperactivity symptoms levels in students suffering from migraine (12).…”

Section: Self-reported Attentional Difficulties In Migrainesupporting

confidence: 74%

Self-perceived attention difficulties are associated with sensory hypersensitivity in migraine

et al. 2020

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Objectives: The aim of the study was to investigate potential interactions between sensory hypersensitivity and attentional difficulties in migraineurs. Methods: Forty-six episodic migraineurs without aura and 46 healthy controls filled out questionnaires on self-perceived attention difficulties and self-reported sensitivity to visual, auditory and olfactory stimulations. Results: Compared to controls, migraineurs reported significantly higher levels of attention difficulty and sensory sensitivity. Sensory hypersensitivity correlated significantly with attentional difficulties in migraineurs (p=0.002), but not with migraine disability or levels of anxiety or depression. Ictal and interictal sensory sensitivity were significantly correlated in migraineurs within visual (p<.001), auditory (p<.001) and olfactory (p=.001) modalities. Conclusion: Self-reported attentional difficulties, multimodal sensory hypersensitivity and the association between both may reflect the fact that external stimuli engage attention in an exacerbated manner in migraineurs, yielding distraction.

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“…In the bias analysis of unmeasured confounders, we corrected for several confounders identified from the literature. 10,14,21,[47][48][49] The largest shifts in point estimates were for parental ADHD and maternal migraine. We estimated the prevalence of the confounders from the literature.…”

Section: Principal Findingsmentioning

confidence: 99%

Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias?

Masarwa

Platt

Filion

2020

Paediatric Perinatal Epid

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Background:The association between acetaminophen use during pregnancy and the development of attention deficit hyperactivity disorder (ADHD) in the offspring may be due to bias. Objectives:The primary objective was to assess the role of potential unmeasured confounding in the estimation of the association between acetaminophen use during pregnancy and the risk of ADHD, through bias analysis. The secondary objective was to assess the roles of selection bias and exposure misclassification. Data sources:We searched MEDLINE, Embase, Scopus, and the Cochrane Library up to December 2018. Study selection and data extraction:We included observational studies examining the association between acetaminophen use during pregnancy and the risk of ADHD. Synthesis:We meta-analysed data across studies, using random-effects model. We conducted a bias analysis to studies that did not adjust for important confounders, to explore systematic errors related to unmeasured confounding, selection bias, and exposure misclassification. Results:The search resulted in seven studies included in our meta-analysis. When adjusted estimates were pooled across all studies, the risk ratio (RR) for ADHD was 1.35 (95% confidence interval [CI] 1.25, 1.46; I 2 = 48%). Sensitivity analysis for unmeasured confounding in this meta-analysis showed that a confounder of 1.69 on the RR scale would reduce to 10% the proportion of studies with a true effect size of RR >1.10. Unmeasured confounding bias analysis decreased the point estimate in five of the seven studies and increased in two studies, suggesting that the observed association could be confounded by parental ADHD. Unadjusted and bias-corrected risk ratios (bcRRs) were: RR = 1.34, bcRR = 1.13; RR = 1.51, bcRR = 1.17; RR = 1.63, bcRR = 1.38; RR = 1.44, bcRR = 1.17; RR = 1.16, bcRR = 1.18; RR = 1.25, bcRR = 1.05;and RR = 0.99, bcRR = 1.18. Conclusions:Bias analysis suggests that the previously reported association between acetaminophen use during pregnancy and an increased risk of ADHD in the offspring may be due to unmeasured confounding. Our ability to conclude a causal association is limited. K E Y W O R D Sacetaminophen, ADHD, bias, confounding, pregnancy

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Comorbidity of migraine with ADHD in adults

Cited by 28 publications

References 40 publications

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

Migraine, attention deficit hyperactivity disorder and screen time in children attending a Sri Lankan tertiary care facility: are they associated?

Self-perceived attention difficulties are associated with sensory hypersensitivity in migraine

Acetaminophen use during pregnancy and the risk of attention deficit hyperactivity disorder: A causal association or bias?

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