Self-perceived attention difficulties are associated with sensory hypersensitivity in migraine

Lévêque, Yohana; Masson, Rémy; Fornoni, Lesly; Moulin, Annie; Bidet-Caulet, Aurélie; Caclin, Anne; Demarquay, Geneviève

doi:10.1016/j.neurol.2020.01.360

Cited by 13 publications

(21 citation statements)

References 37 publications

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“…However, the impact of the overlap of these factors was not investigated. In contrast, in 92 patients with migraine, interictal sensory hypersensitivities, calculated as combined scores for auditory and visual hypersensitivities, were related to self-perceived attention difficulties but not to headache-related disabilities [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Suzuki

Shiina

et al. 2021

J Headache Pain

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Objective Sensory hypersensitivities such as photophobia, phonophobia, and osmophobia are common in patients with migraine. We investigated the burden of these multiple sensory hypersensitivities in migraine. Methods In this cross-sectional study, 187 consecutive patients with migraine (26 men/161 women; age, 45.9 ± 13.2 years) were included. Sensory hypersensitivity symptoms such as photo−/phono−/osmophobia and accompanying symptoms were determined by neurologists in interviews. The Migraine Disability Assessment (MIDAS) was used to assess headache-related disability. The Kessler Psychological Distress Scale (K6) was also administered. Results Photophobia, phonophobia and osmophobia were observed in 75.4%, 76.5% and 55.1% of the patients with migraine, respectively. A significant overlap in sensory hypersensitivities (photo−/phono−/osmophobia) was found; the proportions of patients with 2 and 3 coexisting sensory hypersensitivities were 33.2% and 41.7%, respectively. The MIDAS score was higher in those with 3 sensory hypersensitivity symptoms than in those with 0 to 2 sensory hypersensitivity symptoms. A generalized linear model with ordinal logistic regression analysis revealed that multiple sensory hypersensitivities, younger age, more migraine days per month, and a higher K6 score were significantly related to the higher MIDAS score. Conclusion Our study showed that sensory hypersensitivities commonly occur and overlap in patients with migraine and that multiple sensory hypersensitivity symptoms have a significant impact on headache-related disability.

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Section: Discussionmentioning

confidence: 99%

Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Suzuki

Shiina

et al. 2021

J Headache Pain

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“…Migraine has been associated with attentional abnormalities through subjective reports [15,52,78], neuropsychological tests [89,92], or EEG and event-related potentials (ERPs) studies [65].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical training specifically focusing on distraction and noise suppression may be found useful for symptoms management. Finally, deficient top-down inhibitory mechanisms may play a role in the multimodal hypersensitivity during both the headache phase and the pain-free period [52,57,90,91]. Further research is needed to establish a clearer relationship between sensory complaints and the disruption of the attention processing of sensory stimuli in migraine.…”

Section: Conclusion and Clinical Perspectivesmentioning

confidence: 99%

“…However, in the last decade, converging pieces of evidence have suggested that dysfunctional attention processing of sensory inputs may also participate in migraineurs' hypersensitivity, especially during the attack-free period. Migraineurs self-report attention difficulties in everyday life [15,52] and these difficulties correlate with multimodal sensory sensibility between attacks [52]. Migraineurs display increased electrophysiological markers of attention orienting to incoming stimuli [20,61,64,67], which could be related to the dysfunction of the right temporo-parietal junction (rTPJ) [54,55,61,63].…”

Section: Introductionmentioning

confidence: 99%

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Top-down inhibition of irrelevant information indexed by alpha rhythms is disrupted in migraine

Masson

ElShafei

Demarquay

et al. 2021

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There is growing evidence that migraine is associated with attentional abnormalities, both during and outside migraine attacks, which would impact the cognitive processing of sensory stimulation. However, these attention alterations are poorly characterized and their neurophysiological basis is still unclear. Nineteen migraineurs without aura and nineteen healthy participants were recruited to perform a task which used visually-cued auditory targets and distracting sounds to evaluate conjointly top-down and bottom-up attention mechanisms. Magnetoencephalography (MEG) signals were recorded. We investigated anticipatory alpha activity (power increase and decrease) and distractor-induced gamma activity as markers for top-down (inhibition and facilitation) and bottom-up attention, respectively. Compared to healthy participants, migraineurs presented a significantly less prominent alpha power increase in visual areas in anticipation of the auditory target, indexing a reduced inhibition of task-irrelevant visual areas. However, there was no significant group difference regarding the alpha power decrease in the relevant auditory cortices in anticipation of the target, nor regarding the distractor-induced gamma power increase in the ventral attention network. These results in the alpha band suggest that top-down inhibitory processes in the visual cortices are deficient in migraine but there is no clear evidence supporting a disruption of top-down facilitatory attentional processes. This relative inability to suppress irrelevant sensory information may be underlying the self-reported increased distractibility and contribute to sensory disturbances in migraine.

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“…It is noteworthy that migraine symptoms are not exclusive to the ictal period. If sensory disturbances clearly climax during the attacks, alterations of sensory processing extend beyond the ictal state (Main et al 1997; Vingen et al 1998; Granovsky et al 2018; Lévêque et al 2020). Migraine may be associated to minor cognitive dysfunctions interictally (Zeitlin and Oddy 1984; Hooker and Raskin 1986; Mongini et al 2005; Vuralli et al 2018) and to vertigo and dizziness episodes (Vuković et al 2007; Cha et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Is migraine associated to brain anatomical alterations? New data and coordinate-based meta-analysis

Masson

Demarquay

Meunier

et al. 2020

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A growing number of studies investigate brain anatomy in migraine using voxel- (VBM) and surface-based morphometry (SBM), as well as diffusion tensor imaging (DTI). The purpose of this article is to identify consistent patterns of anatomical alterations associated with migraine. First, 19 migraineurs without aura and 19 healthy participants were included in a brain imaging study. T1-weighted MRIs and DTI sequences were acquired and analyzed using VBM, SBM and tract-based spatial statistics. No significant alterations of gray matter (GM) volume, cortical thickness, cortical gyrification, sulcus depth and white-matter tract integrity could be observed. However, migraineurs displayed decreased white matter (WM) volume in the left superior longitudinal fasciculus. Second, a systematic review of the literature employing VBM, SBM and DTI was conducted to investigate brain anatomy in migraine. Meta-analysis was performed using Activation Likelihood Estimation (ALE) on GM volume data. Alterations of GM volume, WM volume, cortical thickness or white-matter tract integrity were reported in 72%, 50%, 56% and 33% of published studies respectively. Spatial distribution and direction of the disclosed effects were highly inconsistent across studies. The ALE analysis revealed no significant decrease of GM volume in migraine. A significant increase of GM volume in the left superior temporal and angular gyri was detected in migraine, a result however based on a small number of studies. Overall there is to this day no strong evidence of specific brain anatomical alterations reliably associated to migraine. Possible explanations of this conflicting literature are discussed.

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Self-perceived attention difficulties are associated with sensory hypersensitivity in migraine

Cited by 13 publications

References 37 publications

Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Investigating the relationships between the burden of multiple sensory hypersensitivity symptoms and headache-related disability in patents with migraine

Top-down inhibition of irrelevant information indexed by alpha rhythms is disrupted in migraine

Is migraine associated to brain anatomical alterations? New data and coordinate-based meta-analysis

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