Comorbidities and health-related quality of life in Koreans with knee osteoarthritis: Data from the Korean National Health and Nutrition Examination Survey (KNHANES)

Abstract

ObjectivesThis study aimed to evaluate the association of knee osteoarthritis (OA) with comorbidities and health-related quality of life (HRQOL).MethodsA total of 8,907 (weighted n = 13,687,058) participants aged ≥50 years who had undergone knee radiography were selected from the 2010–2012 Korea National Health and Nutrition Examination Survey. OA was classified into four subgroups based on the presence or absence of pain and radiographic OA (ROA): non-OA (Pain-/ROA-), pain only (Pain+/ROA-), ROA only (Pain-/ROA+), and painful ROA (Pain+/ROA+). ROA was defined as Kellgren–Lawrence grade ≥ 2. HRQOL measurements including EuroQOL visual analogue scale (EQ-VAS) scores and the five dimensions and summary index of the EuroQOL-5 dimension (EQ-5D index) were also analyzed. Multivariable logistic regression and linear regression analyses were performed.ResultsAfter adjustment for socioeconomic and lifestyle characteristics, cardiovascular disease, malignancy, and other comorbidities were not significantly associated with OA. Pain only and painful ROA were each significantly associated with limitations in physical activity (odds ratio (OR) 2.66, 95% CI 2.07–3.44, p < 0.001 and OR 2.83, 95% CI 2.25–3.58, p < 0.001, respectively), lower EQ-VAS (β-coefficient = -10.95, p < 0.001 and β-coefficient = -9.75, p < 0.001, respectively), and EQ-5D index (β-coefficient = -0.10, p < 0.001 and β-coefficient = -0.13, p < 0.001) compared with the non-OA group, whereas ROA only was not associated with limitations in physical activity or lower HRQOL score.ConclusionsComorbidities were not significantly associated with knee OA after adjustment. Knee OA was associated with physical activity and HRQOL. Painful knee OA, with or without ROA, was more strongly associated with decreased physical activity and lower quality of life than ROA without pain.

Knee osteoarthritis and its association with mental health and health‐related quality of life: A nationwide cross‐sectional study

“…Jeong et al . reported that patients with osteoarthritis showed an association with a decline of health‐related QoL in the Korean population . However, in the prior study, sex differences were not fully considered, as separate analyses for both sexes were not carried out.…”

“…5 Jeong et al reported that patients with osteoarthritis showed an association with a decline of health-related QoL in the Korean population. 6 However, in the prior study, sex differences were not fully considered, as separate analyses for both sexes were not carried out. Because the threshold risk for osteoarthritis and mental health differs significantly by sex, sex-specification analyses models would be more appropriate.…”

Prevalence of Osteoarthritis and Health-Related Quality of Life in Stroke Patients: A Cross-Sectional Study Using Korean National Health and Nutrition Examination Survey VII

“…Knee osteoarthritis in patients with stroke was associated with an increase in the length of hospitalization and was found to be related to the degree of their daily activities [25]. Gait issues in patients with stroke showed a signi cant relationship with knee pain at rest, and knee osteoarthritis is known to be closely related to functional recovery after the onset of stroke [26,27]. Therefore, when proper evaluation and management including rehabilitation for patients with osteoarthritis are provided, it could improve their HRQoL.…”

Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis

“…Osteoarthritis (OA) is a slow and progressive disorder of joints and cartilage [1]. OA is the most common musculoskeletal disorder and causes social and economic disabilities in the elderly population [2]. Various risk factors are associated with OA including age, obesity, occupation, gender (women are more susceptible than men), inheritance, metabolic diseases, knee trauma, and inertia [3][4][5].…”