Aim To investigate the relationship between knee osteoarthritis, mental health and health‐related quality of life (QoL). Methods This study included 6343 men and women aged ≥50 years from the Korean National Health and Nutrition Examination Survey. Osteoarthritis was defined as Kellgren–Lawrence grade ≥2 in the knee on radiographic images with knee pain. Mental health and health‐related QoL were assessed according to three dimensions (depressive mood, psychological distress and suicidal ideation) and five domains (impaired mobility, impaired self‐care, impaired usual activities, pain/discomfort and anxiety/depression). The odds ratios and 95% confidence intervals (CI) for mental health and health‐related QoL were calculated using multiple logistic regression analyses. Results Compared with the control group, the odds ratios for depressive mood, psychological distress and suicidal ideation in the osteoarthritis group were 2.80 (95% CI 1.31–3.31), 1.92 (95% CI 1.21–3.05) and 1.97 (95% CI 1.31–2.94) in men, and 1.51 (95% CI 1.16–1.95), 1.36 (95% CI 1.07–1.72) and 1.92 (95% CI 1.49–2.46) in women after adjusting for potential confounding variables. Similarly, the odds ratios for impaired mobility, impaired self‐care, impaired usual activities, pain/discomfort and anxiety/depression in the osteoarthritis group were 12.37 (95% CI 8.17–18.72), 3.02 (95% CI 1.84–4.94), 7.33 (95% CI 4.89–10.98), 8.92 (95% CI 5.92–13.45) and 2.56 (95% CI 1.52–4.29) in men, and 8.29 (95% CI 6.41–10.73), 2.53 (95% CI 1.74–3.69), 4.40 (95% CI 3.33–5.80), 4.79 (95% CI 3.72–6.17) and 1.85 (1.44–2.37) in women after adjusting for the same covariables. Conclusions Knee osteoarthritis was significantly associated with deteriorated mental health and health‐related QoL in middle‐aged and older men and women. Geriatr Gerontol Int 2020; 20: 379–383.
Low serum bilirubin levels have been associated with increased risk of cardiovascular disease (CVD) and metabolic syndrome. Testosterone deficiency could also contribute to increased risk of CVD and metabolic syndrome. Therefore, this study aimed to examine the relationship between serum bilirubin level and testosterone deficiency in 1284 Korean men aged 45 to 70 years. Serum bilirubin level was categorized into quartiles: Q1 ≤ 0.7, Q2 0.8–0.9, Q3 1.0–1.1, and Q4 ≥ 1.2 mg/dL. Testosterone deficiency was defined as level less than 8.0 nmol/L, as suggested by the position statement of International Society of Andrology. The overall prevalence of testosterone deficiency was 5.8% and significantly decreased with the quartiles from Q1 to Q4. Compared with the referent fourth quartile (serum bilirubin ≥ 1.2 mg/dL), the ORs (95% CIs) for testosterone deficiency was 2.29 (1.04–4.94) for the first quartile after adjusting for age, fasting glucose, triglyceride, HDL-cholesterol, leukocyte count, hemoglobin, smoking status, and alcohol intake. We found inversely graded associations of serum bilirubin level with testosterone deficiency. These findings suggest that low bilirubin level may be interpreted as a state of testosterone deficiency in middle-aged and older men.
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