Community study of hypothyroidism in Down's syndrome.

Lobo, Evelyn D.; Khan, Madiha; Tew, James D.

doi:10.1136/bmj.280.6226.1253

Cited by 58 publications

(18 citation statements)

References 5 publications

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“…Our finding of hypothyroidism (15%) in patients with Down's syndrome is comparable with the prevalence rates of The age distribution of hypothyroidism cases is shown in Table-III. [15][16][17][18][19] The variation in prevalence in these earlier studies might be related to the age variation among the studied subjects and/or to differences in diagnostic criteria.…”

Section: Discussionmentioning

confidence: 98%

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Biswas

Munsi

Hussain

et al. 2017

Bangladesh J Child Health

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Section: Discussionmentioning

confidence: 98%

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Biswas

Munsi

Hussain

et al. 2017

Bangladesh J Child Health

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“…Comparison with other reports is difficult, as prevalence will vary according to the age of the population tested and the type and degree of thyroid dysfunction measured [9]. For example, Lobo et al [13] reported gross hypothyroidism (TSH ≥23 mU/l) in 3/83 subjects (3.6%) with DS aged 5–21 years, whereas Tuysuz and Beker [14] found raised TSH in 90/320 patients with DS aged between 5 days and 10 years, of whom 9 had transient, congenital or acquired hypothyroidism and 81 (25.3% of the total) had compensated hypothyroidism (TSH 6–20 mU/l).…”

Section: Discussionmentioning

confidence: 99%

Hashimoto’s Thyroiditis in Down’s Syndrome: Clinical Presentation and Evolution

Popova¹,

Paterson²,

Brown

et al. 2008

Horm Res Paediatr

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Aim: It was the aim of this study to describe the presentation and clinical course of Hashimoto’s thyroiditis (HT) in children with Down’s syndrome (DS) in 2 Scottish health regions. Patients and Methods: We retrospectively analysed clinical, biochemical and thyroid antibody status in 38 patients with DS with HT diagnosed from 1989 to 2004. Results: The sex distribution was similar (20 males, 18 females), with a median age of 12.3 years (range 2.1–17.7). Of the 38 patients reviewed, 29 were identified by screening. A goitre was present in 6/38 patients. Thyroid antibodies were positive in 36/38 patients, negative in 1/38, and data were unavailable for 1/38. At presentation, 37/38 patients were hypothyroid: 21/37 with compensated hypothyroidism (6 treated initially) and 16/37 with decompensated hypothyroidism (all treated). Of the 15/21 compensated patients who were untreated initially, only 3 remitted while 12 showed disease progression prompting treatment. In the decompensated group, 1/16 patient pursued a fluctuating course between hypo- and hyperthyroidism. The final patient, who was hyperthyroid at presentation, also showed marked fluctuation in thyroid function over a 5-year period. Conclusion: The natural history of HT in DS is unusual, with no female predominance and infrequent goitre in our cohort. While almost all patients required treatment eventually, clinicians should be aware that the disease may pursue a fluctuating course between hypo- and hyperthyroidism.

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“…Several studies have demonstrated a high incidence of acquired hypothyroidism in children with Down syndrome [8,9,11].…”

Section: Introductionmentioning

confidence: 99%

Pericardial effusion as a sign of acquired hypothyroidism in children with Down syndrome

et al. 1993

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In three children with Down syndrome and acquired hypothyroidism echocardiography was performed before and after the start of L-thyroxine treatment. Initial studies revealed pericardial effusions which resolved during treatment suggesting that they were caused by hypothyroidism. The incidence of hypothyroidism in Down syndrome is high, but the diagnosis is often missed for lack of specific clinical criteria. The finding of pericardial effusion by echocardiography may be essential in discovering thyroid dysfunction. The cases illustrate that regular thyroid function tests are important in Down syndrome.

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Community study of hypothyroidism in Down's syndrome.

Abstract: 1253 siderable hazard.4 5 It must be carefully monitored and clotting factors and platelet concentrates given as soon as they are indicated. '

Cited by 58 publications

References 5 publications

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Hashimoto’s Thyroiditis in Down’s Syndrome: Clinical Presentation and Evolution

Pericardial effusion as a sign of acquired hypothyroidism in children with Down syndrome

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Community study of hypothyroidism in Down's syndrome.

Abstract: 1253 siderable hazard.4 5 It must be carefully monitored and clotting factors and platelet concentrates given as soon as they are indicated. '

Cited by 58 publications

References 5 publications

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Hashimoto’s Thyroiditis in Down’s Syndrome: Clinical Presentation and Evolution

Pericardial effusion as a sign of acquired hypothyroidism in children with Down syndrome

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Product

Resources

About

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome