Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Biswas, Rabi; Munsi, Abu Sayed; Hussain, Manzoor; Alam, Jahangir; Ahmed, Asm Nawshad Uddin

doi:10.3329/bjch.v39i3.31576

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 Biswas R et al also mentioned that 15% had hypothyroidism and subclinical hypothyroidism was the leading thyroid disorder seen in his study of hospitalized Down children in a tertiary care hospital in Bangladesh. 19 In our study, we have also observed majority (63%) of the hypothyroid Down children had subclinical hypothyroidism.…”

Section: Discussionsupporting

confidence: 71%

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Zabeen¹,

Mohsin

Jesmin³

et al. 2021

Birdem Med J

View full text Add to dashboard Cite

Background: Down syndrome or trisomy 21 is one of the most common chromosomal disorders with moderate intellectual disability. In addition to mental retardation, this syndrome is associated with different congenital anomalies and characteristic dysmorphic features. Affected individuals are more susceptible to congenital heart disease and digestive anomalies, pulmonary complications, immune and endocrine system disorders. While several international studies have shown association of co-morbidities with trisomy 21, there is insufficient data available in Bangladesh.The present study aimed to evaluate the associated co-morbidities in children with Down syndrome. Methods: A cross-sectional study was conducted among pediatric cases with Down syndrome who attended the endocrine outpatient department (OPD) of BIRDEM General Hospital from June 2006 to December 2016. The cases were diagnosed either by Karyotyping or by characteristic phenotypes.The clinical and laboratory data of the patients were collected from outpatient history records for analysis. Results: There were total 42 children with Down syndrome, with mean age 4.2 years at assessment and female predominance (1.47:1). Thyroid dysfunction was the most common (69%) followed by congenital heart disease (57%). Among the thyroid disorders, acquired hypothyroidism was found in 55% cases, congenital hypothyroidism in 41% cases and only one had hyperthyroidism. Isolated patent ductus arteriosus (PDA) and atrial septal defect (ASD) comprised the commonest single congenital heart disease found in 53% and combined atrioventricular septal defect was the commonest among complex congenital cardiac defect observed in our study. Both thyroid dysfunction and congenital heart disease were found more in female children with Down syndrome than their male counterpart and it was found statistically significant. Fifty percent of our Down syndrome cases were referred from other healthcare centers to address developmental delay. Conclusion: Hypothyroidism and congenital heart disease are frequently associated in Down syndrome children in Bangladesh. This calls for developing awareness among health professionals to diagnose comorbidities at an early stage and to form recommendations for long term follow up. BIRDEM Med J 2021; 11(3): 191-196

show abstract

Section: Discussionsupporting

confidence: 71%

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Zabeen¹,

Mohsin

Jesmin³

et al. 2021

Birdem Med J

View full text Add to dashboard Cite

show abstract

“…The gap between two extreme socioeconomic groups in respect of 1 + ANC rate was 48.0-93.0% and 82.4-98.9% in 2011 and 2017, respectively [9,10]. Although there have been recent improvements in child and maternal health in Bangladesh [11], persistent inequalities in healthcare indicators still exist [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic inequality and urban-rural disparity of antenatal care visits in Bangladesh: A trend and decomposition analysis

Biswas,

Kumar,

Rahaman

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Socioeconomic inequality in antenatal care visits is a great concern in developing countries including Bangladesh; however, there is a scarcity of investigation to assess the factors of inequality and these changes over time. In this study, we investigated the trend of socioeconomic inequalities (2004–2017) in 1+ANC and 4+ANC visits, and extracted determinants contributions to the observed inequalities and urban-rural disparities in Bangladesh over the period from 2011 to 2017. Methods The data from the Bangladesh Demographic and Health Surveys (BDHS) conducted in 2004, 2007, 2011 and 2017 were analyzed in this study. The analysis began with exploratory and bivariate analysis, followed by the application of logistic regression models. To measure the inequalities, the Erreygers concentration index was used, and regression-based decomposition analyses were utilized to unravel the determinant’s contribution to the observed inequalities. The Blinder-Oaxaca type decomposition is also used to decompose the urban-rural disparity into the factors. Results Our analysis results showed that the prevalence of 1+ANC and 4+ANC visits has increased across all the determinants, although the rate of 4+ANC visits remains notably low. The magnitudes of socioeconomic inequality in 4+ANC visits represented an irregular pattern at both the national and urban levels, whereas it increased gradually in rural Bangladesh. However, inequalities in 1+ANC visits declined substantially after 2011 across the national, rural and urban areas of Bangladesh. Decomposition analyses have suggested that wealth status, women’s education, place of residence (only for 4+ANC visits), caesarean delivery, husband education, and watching television (TV) are the main determinants to attribute and changes in the level of inequality and urban-rural disparity between the years 2011 and 2017. Conclusions According to the findings of our study, it is imperative for authorities to ensure antenatal care visits are more accessible for rural and underprivileged women. Additionally, should focus on delivering high-quality education, ensuring the completion of education, reducing income disparity as well as launching a program to enhance awareness about health facilities, and the impact of caesarean delivery.

show abstract

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Cited by 2 publications

References 19 publications

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Socioeconomic inequality and urban-rural disparity of antenatal care visits in Bangladesh: A trend and decomposition analysis

Contact Info

Product

Resources

About

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome

Cited by 2 publications

References 19 publications

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Comorbidities in children with Down syndrome: experience in a tertiary care hospital of Bangladesh

Socioeconomic inequality and urban-rural disparity of antenatal care visits in Bangladesh: A trend and decomposition analysis

Contact Info

Product

Resources

About

Functional Status of Thyroid Gland in Hospitalized Children With Downs Syndrome