Pericardial effusion as a sign of acquired hypothyroidism in children with Down syndrome

Werder, E A; Torresani, Toni; Navratil, Francesca; Arbenz, U; Eiholzer, Urs; Pelet, B; Burri, Melchior; Schwarzenbach, P.; Hunziker, U. A.

doi:10.1007/bf01955895

Cited by 16 publications

(15 citation statements)

References 12 publications

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“…In many cases of Down syndrome associated with PE, there is also a high prevalence of hypothyroidism and myelopoiesis [11,12,13,14]. In this study, however, karyotypes of fetuses with isolated PE were all normal.…”

Section: Discussioncontrasting

confidence: 37%

Clinical Outcomes of Prenatally Diagnosed Cases of Isolated and Nonisolated Pericardial Effusion

Kyeong

Won²,

Lee³

et al. 2014

Fetal Diagn Ther

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Objective: The purpose of this study was to investigate the clinical outcome of fetal pericardial effusion (PE). Methods: This study involved a retrospective review of prenatally diagnosed PE cases. The criterion for inclusion was pericardial fluid in an area greater than 2 mm in diameter. Results: A total of 276 cases of PE and 252 cases diagnosed with other anomalies were initially reviewed. PE is associated with cardiac malformation, hydrops fetalis, extracardiac abnormalities, infections, anemias, intrauterine growth restriction, and aneuploidy markers in fetuses. Of these reviewed cases, 24 cases of isolated fetal PE were studied. In all cases, pericardial fluid filled an area ranging from 2 to 17 mm in diameter. Four cases of isolated PE had an abnormal postnatal condition, and 3 cases were excluded due to lack of follow-up. The size of the PE was not related to the regression of pericardial fluid, adverse outcomes or mortality rate associated with the isolated PE. All newborns were healthy, and there were no chromosomal abnormalities in the study population. Conclusions: There were no adverse clinical outcomes or chromosomal abnormalities in the fetuses diagnosed with isolated PE. Most cases of isolated PE resolved spontaneously and were associated with a good prognosis.

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Section: Discussioncontrasting

confidence: 37%

Clinical Outcomes of Prenatally Diagnosed Cases of Isolated and Nonisolated Pericardial Effusion

Kyeong

Won²,

Lee³

et al. 2014

Fetal Diagn Ther

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“…Other abnormalities may suggest the presence of a thyroid disorder; eg, abnormal electrocardiogram consistent with hypothyroidism, (Murdoch, 1977), presence of a goitre (Ruvalcaba, 1969;Hollingworth, 1974), detection of a pericardial effusion (Werder et al, 1993), dementia (Prasher & Krishnan, 1993), detection of alopecia areata (duVivier & Munro, 1975), premature puberty (Maranon et al, 1951).…”

Section: Clinical Features Of Thyroid Disorders In Down Syndromementioning

confidence: 99%

Down Syndrome and Thyroid Disorders: A Review

Prasher¹

1999

Downs Syndr. Res. Pract.

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Thyroid disorders are common in the Down syndrome population but many specific areas of importance remain to be resolved. A detailed review of previously published case reports and research studies highlighting the clinical association between Down syndrome and thyroid disorders was undertaken. Historical, epidemiological, immunological, diagnostic and treatment issues are addressed. Recommendations for future management and research are considered.

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“…In adults, pericardial effusion may be present in 10 to 30 % Corresponding author: Josephine Ho MD josephine.ho@albertahealthservices.ca of patients with hypothyroidism 2,3 . In the pediatric population, pericardial effusion associated with hypothyroidism is rare and most of the reported cases are in children with Down syndrome [4][5][6][7] . In this report, six cases of pericardial effusion in children with severe hypothyroidism are presented.…”

Section: Introductionmentioning

confidence: 99%

Pericardial Effusion in Severe Hypothyroidism in Children

Martinez-Soto

Deal

Stephure

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

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Pleural and pericardial effusion is a rare complication of severe hypothyroidism in children but can be present in 10 to 30 % of adults. Most pediatric cases have been in children with Down syndrome. In this report, six cases of pericardial effusion in children with severe hypothyroidism with and without trisomy 21 are presented. In all patients, the pericardial effusion was managed successfully without pericardiocentesis. The effusions resolved completely in 2 to 12 months after initiation of thyroxin replacement. In conclusion, hypothyroidism should be considered in any child with unexplained pericardial or pleural effusions. Early recognition and treatment with thyroid hormone replacement could eliminate the need for unnecessary diagnostic procedures and invasive treatment measures and reduce the risk of progression to cardiac tamponade. KEY WORDSpericardial effusion, hypothyroidism

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Pericardial effusion as a sign of acquired hypothyroidism in children with Down syndrome

Cited by 16 publications

References 12 publications

Clinical Outcomes of Prenatally Diagnosed Cases of Isolated and Nonisolated Pericardial Effusion

Clinical Outcomes of Prenatally Diagnosed Cases of Isolated and Nonisolated Pericardial Effusion

Down Syndrome and Thyroid Disorders: A Review

Pericardial Effusion in Severe Hypothyroidism in Children

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