Community-Acquired <i>Staphylococcus argenteus</i> Sequence Type 2250 Bone and Joint Infection, France, 2017

Rigaill, Josselin; Grattard, Florence; Grange, Sylvain; Forest, Fabien; Haddad, Élie; Carricajo, Anne; Tristan, Anne; Laurent, François; Botelho-Nevers, Élisabeth; Verhoeven, Paul

doi:10.3201/eid2410.180727

Cited by 20 publications

(15 citation statements)

References 10 publications

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“…However, S. argenteus has been regarded as a low virulent species within Staphylococcus aureus-related complex [2,16]. Nevertheless, there is an accumulation of reports on serious invasive infections including not only skin and soft tissue infections but also necrotizing fasciitis [2,4], bone and joint infections [5,10,14,18] and bacteremia [13]. In addition, the only case of a PJI reported so far concerns a patient suffering from a persistent and recurrent infection in which a S. argenteus strain and its small colony variants (SCVs) was isolated [14].…”

Section: Discussionmentioning

confidence: 99%

“…The geographical distribution of this species is unknown although many of the early reports originate from Africa, Asia and Australia/New Zealand [4,5,6,7]. From Europe the reports are sparse; 25 S. argenteus genomes from Denmark [8], low prevalence (0.16%) in a nationwide Belgian study [9], a case report from France [10] and one strain from UK [3]. However, among isolates classically identified as methicillin-resistant S. aureus (MRSA) in Sweden that is normally considered a low prevalence country regarding MRSA, S. argenteus has also been identified [11,12].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

“…The clinical features of S. argenteus infections are infrequently described [1] but include bacteremia [13], skin and soft tissue infections [8,9] and a bone and joint infection [10]. Hitherto, only one case of a prosthetic hip infection, from China, has been described previously [14].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

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Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

Söderquist

Wildeman

Stenmark

et al. 2020

J. Bone Joint Infect.

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Abstract. This report presents a case of prosthetic hip infection caused by Staphylococcus argenteus, a potentially overlooked etiology of prosthetic joint infections (PJIs). Whole-genome sequencing showed that the S. argenteus isolate was an ST2250 and clustered within other CC2250 isolates, the largest clonal group of S. argenteus. This sequence type is prevalent and may be associated with invasive infections. The present isolate was phenotypically fully susceptible to all tested antimicrobial agents and genome analysis did not detect any resistance genes, nor were any staphylococcal cassette chromosome residues detected. Despite initial appropriate management with debridement and biofilm-active antibiotics, the outcome was unfavorable with recurrence and a persistent infection treated with suppressive antibiotics. Regarding the repertoire of genomic traits for virulence in S. argenteus, PJIs caused by this bacterium should be treated accordingly as Staphylococcus aureus PJIs.

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Section: Discussionmentioning

confidence: 99%

Section: Staphylococcus Aureusmentioning

confidence: 99%

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Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

Söderquist

Wildeman

Stenmark

et al. 2020

J. Bone Joint Infect.

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“…S. argenteus is mostly connected to skin and soft tissue infections and has only rarely caused invasive disease [6,9,10]. At first, S. argenteus was thought to be less virulent than S. aureus, due to the lack of the yellow pigment staphyloxantin [11], which confers resistance against oxidative stress and neutrophil killing [12].…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus argenteus and Staphylococcus schweitzeri are cytotoxic to human cells in vitro due to high expression of alpha-hemolysin Hla

2019

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Staphylococcus argenteus and Staphylococcus schweitzeri are newly identified species of the S. aureus -related complex. S. argenteus, as occurring globally and showing significant prevalence and comparable infection and morbidity rates compared to S. aureus , is becoming clinically important. Whole genome sequencing has revealed the presence of several virulence genes but the molecular mechanisms of S. argenteus infection and virulence are largely unknown. Here, we studied the effect of a previously characterized clinical S. argenteus isolate on human cells in vitro . The clinical isolate, together with the S. argenteus type strain MSHR1132T and the S. schweitzeri type strain FSA084T, had a cytotoxic effect on the cells, which showed necrotic cell death after a few hours of treatment. The protein causing the cytotoxic effect was purified and identified by mass spectrometry as alpha-hemolysin, Hla, which is awell-known pore-forming toxin in S.aureus . The cytotoxic effect could be blocked with an antibody against Hla. S.argenteus showed 12–15 fold higher expression levels of hla at the RNA level and 4–6 fold higher expression levels at the protein level compared to S.aureus . The higher expression levels of hla were supported by higher RNA levels of the regulatory factors sarA and saeR . Also, the RNAIII component of the accessory gene regulator (agr) quorum sensing system was 8,000–10,000 fold higher in the S.argenteus isolates compared to S.aureus . This is the first study on the effect of S.argenteus on ahuman cell line and strengthens the idea of significant virulence of S.argenteus .

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“…It causes infections comparable to those triggered by S. aureus , e.g., skin and soft tissue infections, bacteremia and sepsis, and therefore can be life-threatening. Sporadic cases have been reported mainly in Asia, Oceania and Pacific islands [ 2 , 3 ] and more rarely in Europe [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection

Diot

Dyon-Tafani

Bergot

et al. 2020

IJMS

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Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated S. argenteus strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in comparison with two other strains of S. argenteus and two S. aureus isolates. It appeared that this S. argenteus PJI strain combined biofilm formation, osteoblast invasion and intracellular persistence abilities together with genes potentially involved in the escape of the host immune defenses, which might explain the chronicization of the infection.

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Community-Acquired Staphylococcus argenteus Sequence Type 2250 Bone and Joint Infection, France, 2017

Cited by 20 publications

References 10 publications

Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

Staphylococcus argenteus and Staphylococcus schweitzeri are cytotoxic to human cells in vitro due to high expression of alpha-hemolysin Hla

Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection

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