Common carotid artery intima media thickness and post-stroke cognitive impairment

Talelli, Penelope; Ellul, John; Terzis, George; Lekka, N.P.; Gioldasis, G; Chrysanthopoulou, Athina; Papapetropoulos, Thodoros

doi:10.1016/j.jns.2004.05.013

Cited by 45 publications

(41 citation statements)

References 43 publications

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“…What is the rationale behind this assumption? In non-HIV-infected patients, it has been shown that increased IMT was independently associated with cognitive impairment in patients with asymptomatic carotid artery atherosclerosis and cognitive decline 1 year after an acute ischaemic stroke [14,15,16,17]. In the study of Johnston et al [14], a greater IMT of both the left and right common carotid arteries was associated with a lower score on the Modified Mini-Mental State Examination and Digit Symbol Substitution Test scores (a test of psychomotor function) even if adjusted for other risk factors for cognitive dysfunction such as diabetes and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Carotid Intima-Media Thickness in HIV-Infected Individuals: Relationship of Premature Atherosclerosis to Neuropsychological Deficits?

Yaldizli

Kastrup²,

Obermann³

et al. 2006

Eur Neurol

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Background: Intima-media thickness (IMT) measured by extracranial duplex sonography is a surrogate marker for atherosclerosis. It is well known that IMT is greater in HIV patients than in age-matched healthy controls due to HIV- induced endothelial damage and metabolic side-effects of antiretroviral therapy. However, it remains unclear whether atherosclerosis has an additional impact on cognitive function in HIV patients. Therefore, the objective of this study was to investigate the correlation between IMT and neuropsychological deficits in HIV patients. Methods: 47 HIV patients and 40 age-matched healthy controls were examined by extracranial ultrasound 2 and 3 cm before the flow divider to evaluate differences in IMT. Possible neuropsychological deficits in HIV patients were assessed using a battery of 10 neuropsychological tests. Results of neuropsychological tests and markers of disease severity were correlated with IMT in HIV patients. Results: IMT was significantly greater in patients than in healthy controls (p < 0.001). However, none of the neuropsychological tests correlated significantly with IMT measurements in HIV patients. There was only a weak correlation between deficits in attention and IMT in HIV patients (r = 0.44; p = 0.005), which was non-significant after correction for multiple comparisons. Markers of disease severity (CD4 cell count, HIV load in plasma, duration of HIV disease) did not correlate with IMT either. Conclusion: IMT was greater in HIV patients compared to age-matched controls but it appears that premature atherosclerosis has no additional impact on the evolution of neuropsychological deficits in HIV patients. IMT did not correlate with the severity of immunodeficiency.

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Section: Discussionmentioning

confidence: 99%

Carotid Intima-Media Thickness in HIV-Infected Individuals: Relationship of Premature Atherosclerosis to Neuropsychological Deficits?

Yaldizli

Kastrup²,

Obermann³

et al. 2006

Eur Neurol

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“…One community-based study reported a significant association between increased IMT and lower visual attention and psychomotor speed for both men and women [12], while another found a similar relationship only in men with carotid plaques [13]. IMT was found to be a good predictor of cognitive decline over time in stroke patients [14] but not in community dwelling elderly [15]. These differences are likely due to the fact that IMT values in community samples are generally well below the accepted cut off of 0.9 mm indicating vascular damage from atherosclerosis [13;15].…”

Section: Introductionmentioning

confidence: 97%

Carotid artery intima-media thickness and cognition in cardiovascular disease

Haley

Forman

Poppas

et al. 2007

International Journal of Cardiology

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Background-Increased carotid artery intima-media thickness (IMT) is a non-invasive marker of systemic arterial disease. Increased IMT has been associated with atherosclerosis, abnormal arterial mechanics, myocardial infarction, and stroke. Given evidence of a relationship between cardiovascular health and attention-executive-psychomotor functioning, the purpose of this study was to examine IMT in relation to neuropsychological test performance in patients with a variety of cardiovascular diagnoses.

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“…Talelli et al. (2004) also reported that the cognitive impairment of 1 year after stroke was independently correlated with higher common carotid artery intima‐media thickness. Interestingly, one recent study showed that cognitive disfunction was correlated with severe right carotid artery stenosis (Yue et al., 2016a).…”

Section: Discussionmentioning

confidence: 93%

Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

Lin

et al. 2016

Brain and Behavior

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BackgroundAcute ischemic stroke has been recognized as one key cause of vascular cognitive impairment (VCI). The purpose of this study was to evaluate the correlation between carotid artery stenosis and post VCI in acute ischemic stroke patients.MethodsIn this study, B‐mode ultrasound was applied to measure the degree of carotid artery stenosis. After 1 year, the stroke patients’ cognitive function was assessed by the mini‐mental state examination (MMSE) score. The relationship between the VCI and degree of carotid artery stenosis was evaluated by multivariate regression analysis.Results VCI was observed in 136 (37.2%) of the 365 participants. High degree of carotid artery stenosis was significantly correlated with VCI (p < .01), and this correlation remained unchanged even adjustment for age, gender, education level, stroke features, and vascular risk factors.ConclusionsThese findings indicate that high‐grade stenosis of carotid artery is positively correlated with post stroke VCI in patients with acute ischemic stroke. The evaluation of 1 year post stroke cognitive function may be a potential tool for screening stroke patients at risk of VCI.

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Common carotid artery intima media thickness and post-stroke cognitive impairment

Cited by 45 publications

References 43 publications

Carotid Intima-Media Thickness in HIV-Infected Individuals: Relationship of Premature Atherosclerosis to Neuropsychological Deficits?

Carotid Intima-Media Thickness in HIV-Infected Individuals: Relationship of Premature Atherosclerosis to Neuropsychological Deficits?

Carotid artery intima-media thickness and cognition in cardiovascular disease

Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

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