Carotid artery intima-media thickness and cognition in cardiovascular disease

Haley, Andreana P.; Forman, Daniel E.; Poppas, Athena; Hoth, Karin F.; Gunstad, John; Jefferson, Angela L.; Paul, Robert; Ler, Albert; Sweet, Lawrence H.; Cohen, Ronald A.

doi:10.1016/j.ijcard.2006.10.032

Cited by 76 publications

(88 citation statements)

References 37 publications

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“…The system is involved in regulating attention, switching attentional focus, and task preparation 42 and is known to be affected early in the development of vascular cognitive impairment. [43][44][45] This interpretation is supported by our present finding that greater task-related BOLD response in these regions was associated with better task performance and faster reaction times. The cross-sectional nature of our study limits our ability to infer future cognitive trajectories from the observed functional activation changes.…”

Section: Discussionsupporting

confidence: 72%

“…Support is provided by a growing body of literature documenting that peripheral cardiovascular dysfunction is related to poor cerebrovascular health and diminished cognitive function in older patients with cardiovascular disease. [43][44][45][51][52][53][54][55] Due to the multifaceted nature of MetS, further research is necessary to explore the contributions of frank vascular disease to the observed cognitive taskϪrelated BOLD response changes in midlife. Further exploration of other potential mechanisms such as alterations in cerebral glucose metabolism and inflammation will also be valuable.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Hoth¹,

Gonzales²,

Tarumi³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:MetS is a cluster of risk factors associated with significant cardiovascular morbidity and mortality and diminished cognitive function. Given that little is known about the early signs of brain vulnerability related to persistent metabolic dysfunction, we set out to determine whether cognitively healthy middle-aged individuals with MetS exhibit an altered cerebrovascular response to a cognitive challenge relative to those without MetS. MATERIALS AND METHODS: Forty neurologically healthy adults aged 40 -60 years (19 with MetS and 21 healthy controls) performed a 2-back verbal working memory task during fMRI. We compared BOLD responses between the 2 groups in 8 a priori regions of interest previously shown to be associated with the 2-back in patients with cardiovascular disease.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Hoth¹,

Gonzales²,

Tarumi³

et al. 2010

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…The RBANS does not contain a measure of executive function, which is often impacted by subcortical ischemic vascular disease (Putzke et al 1998;Gunning-Dixon and Raz 2000;Saxby et al 2003;Cook et al 2004; Kramer et al 2007; Paul et al 2005;Haley et al 2007). Although neuropsychological status has not been examined in the context of A1166C, it is possible that group differences would be evident on cognitive measures inclusive of executive function.…”

Section: Discussionmentioning

confidence: 99%

“…Descriptions of postprocessing techniques are included in a previous study of the same participants . The ratio approach corrects for head size on an individual basis (Sanfilipo et al 2004) and has been utilized in previous studies of SH Haley et al 2007;Lane et al 2011;Opherk et al 2014). Previous research comparing this approach with other standardization techniques has revealed minimal to no differences in results, with no statistically superior standardization measure (Bigler et al 2004;Tate et al 2011).…”

Section: Neuropsychological Testingmentioning

confidence: 99%

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Salminen

Schofield

Pierce

et al. 2014

AGE

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Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact of AGTR1 A1166C on white matter integrity and cognition is less clear in a healthy aging population. The present study utilized indices of neuroimaging and neuropsychological assessment to examine the impact of the A1166C polymorphism on subcortical hyperintensities (SH) and cognition in 49 healthy adults between ages 51-85. Using a dominant statistical model (CC + CA (risk) vs. AA), results revealed significantly larger SH volume for individuals with the C1166 variant (p<0.05, partial eta 2 = 0.117) compared with those with the AA genotype. Post hoc analyses indicated that increased SH volume in C allele carriers could not be explained by vascular factors such as pulse pressure or body mass index. In addition, cognitive performance did not differ significantly between groups and was not significantly associated with SH in this cohort. Results suggest that presence of the C1166 variant may serve as a biomarker of risk for suboptimal brain integrity in otherwise healthy older adults prior to changes in cognition.

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“…Haley et al. (2007) reported that carotid artery stenosis was associated with worse neuropsychological performance. Recent study showed that both symptomatic and asymptomatic carotid stenosis are associated with cognitive impairment (Wang, Mei, & Zhang, 2016).…”

Section: Introductionmentioning

confidence: 99%

Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

Lin

et al. 2016

Brain and Behavior

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BackgroundAcute ischemic stroke has been recognized as one key cause of vascular cognitive impairment (VCI). The purpose of this study was to evaluate the correlation between carotid artery stenosis and post VCI in acute ischemic stroke patients.MethodsIn this study, B‐mode ultrasound was applied to measure the degree of carotid artery stenosis. After 1 year, the stroke patients’ cognitive function was assessed by the mini‐mental state examination (MMSE) score. The relationship between the VCI and degree of carotid artery stenosis was evaluated by multivariate regression analysis.Results VCI was observed in 136 (37.2%) of the 365 participants. High degree of carotid artery stenosis was significantly correlated with VCI (p < .01), and this correlation remained unchanged even adjustment for age, gender, education level, stroke features, and vascular risk factors.ConclusionsThese findings indicate that high‐grade stenosis of carotid artery is positively correlated with post stroke VCI in patients with acute ischemic stroke. The evaluation of 1 year post stroke cognitive function may be a potential tool for screening stroke patients at risk of VCI.

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Carotid artery intima-media thickness and cognition in cardiovascular disease

Cited by 76 publications

References 37 publications

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Functional MR Imaging Evidence of Altered Functional Activation in Metabolic Syndrome

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

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