Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

Li, Xuefeng; Ma, Xiaodong; Lin, Jing; He, Xiangqin; Tian, Feng; Kong, Dong-mei

doi:10.1002/brb3.606

Cited by 18 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Asymptomatic carotid artery stenosis (CAS) and carotid artery occlusion (CAO) are characterized by the presence of extracranial internal carotid atherosclerotic stenosis in the ipsilateral carotid perfusion region in individuals without a recent history of ischemic stroke or transient ischemic attack (TIA) [ 1 , 2 ]. Stroke is often an important factor leading to impaired neurocognitive function in patients [ 3 – 6 ]. Severe internal carotid artery (ICA) stenosis (>50%) is associated with a higher incidence rate of silent cerebral infarction [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation

Liu

et al. 2020

Neural Plasticity

View full text Add to dashboard Cite

Asymptomatic carotid artery stenosis (CAS) and occlusion (CAO) disrupt cerebral hemodynamics. There are few studies on the brain network changes and compensation associated with the progression from chronic CAS to CAO. In the current study, our goal is to improve the understanding of the specific abnormalities and compensatory phenomena associated with the functional connection in patients with CAS and CAO. In this prospective study, 27 patients with CAO, 29 patients with CAS, and 15 healthy controls matched for age, sex, education, handedness, and risk factors underwent neuropsychological testing and resting-state functional magnetic resonance (rs-fMRI) imaging simultaneously; graph theoretical analysis of brain networks was performed to determine the relationship between changes in brain network connectivity and the progression from internal CAS to CAO. The global properties of the brain network assortativity (p=0.002), hierarchy (p=0.002), network efficiency (p=0.011), and small-worldness (p=0.009) were significantly more abnormal in the CAS group than in the control and CAO groups. In patients with CAS and CAO, the nodal efficiency of key nodes in multiple brain regions decreased, while the affected hemisphere lost many key functional connections. In this study, we found that patients with CAS showed grade reconstruction, invalid connections, and other phenomena that impaired the efficiency of information transmission in the brain network. A compensatory functional connection in the contralateral cerebral hemisphere of patients with CAS and CAO may be an important mechanism that maintains clinical asymptomatic performance. This study not only reveals the compensation mechanism of cerebral hemisphere ischemia but also validates previous explanations for brain function connectivity, which can help provide interventions in advance and reduce the impairment of higher brain functions. This trial is registered with Clinical Trial Registration-URL http://www.chictr.org.cn and Unique identifier ChiCTR1900023610.

show abstract

Section: Introductionmentioning

confidence: 99%

Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation

Liu

et al. 2020

Neural Plasticity

View full text Add to dashboard Cite

show abstract

“…Fibrovasküler proliferasyonun internal limitan membranın dışına çıktığı DRP sınıflandırması ise proliferatif DRP'dir (7,8). Bu olgu sunumun- (11,12). DM hastalığı olan bireylerde her iki gözün DRP seviyeleri farklı gözlendiğinde mutlaka karotis arter sistemi incelemesi yapılması gerekmektedir.…”

Section: Discussionunclassified

Tek Taraflı Karotis Arter Stenozunda Diabetik Retinopati

Alikma

Unsal

2019

SDÜ Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Polikliniğimize sağ gözünde az görme şikayeti ile başvuran, anamnezinde dört yıldır tanılı tip 2 diabetes mellitus (DM) olan 59 yaşındaki kadın hasta değerlendirildi. Oftalmolojik muayenede görme keskinliği (GK) Snellen eşeline göre sağ gözde 0,15, sol gözde 0,9, göz içi basıncı her iki gözde 16 mmHg olarak saptandı. Fundus muayenesinde sağ gözde optik disk başından vitre içine uzanan proliferatif fibrovasküler yapı ile birlikte dağınık intraretinal hemorajilerin olduğu izlendi. Sol gözün fundus muayenesinde sadece dağını intraretinal hemorajilerin gözlendi. Her iki gözün fundus fotoğrafı ve fundus flourescein anjiyografisi (FFA) çekildi. Fundus muayenesinde ve FFA'da iki göz arasında diyabetik retinopati (DRP) seviyeleri farklı olduğu için hasta kalp damar cerrahisi ile konsülte edildi. Karotis arter anjiyografisinde sağ internal karotis arterde ileri derecede stenoz saptandı. Bu olgu sunumunda asimetrik tutulumlu DRP'ye eşlik eden karotis arter stenozu olan bir olguyu sunmayı amaçladık.

show abstract

“…Patients with ACAS have a higher risk of ischemic stroke with higher mortality. 4 , 5 However, delayed treatment due to lack of attention in the early stages can be fatal once it strikes. Therefore, early diagnosis of ACAS is very important.…”

Section: Introductionmentioning

confidence: 99%

Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis

Lü

Long

et al. 2021

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Objective A close relationship of microRNAs (miRNAs) with various human diseases has been widely reported, including cardiovascular disease. The current study attempted to examine the abnormal expression of miR-27b in asymptomatic carotid artery stenosis (ACAS), its diagnostic value and predictive value for the development of ACAS were also assessed. Methods Clinical serum samples were collected from both ACAS patients and healthy individuals, and levels of miR-27b in the clinical samples were detected using Real-time quantitative PCR. Cerebral ischemia events (CIEs) of patients during the 5-year follow-up were collected. The diagnostic and predictive values of serum miR-27b was assessed via plotting Receiver operating characteristic (ROC) and Kaplan-Meier curves. Multivariate cox regression analysis was performed for clinical independent index analysis. Results ACAS patients had higher levels of miR-27b than the healthy subjects. There were close association of serum miR-27b levels with total cholesterol (TC) level, absence of hypertension and degree of carotid stenosis. High levels of miR-27b could differentiate ACAS cases from healthy subjects, and predicted the high incidence of CIEs. MiR-27b could be used as an independent predictor of cerebrovascular events via multiple Cox regression analysis ( P = .031). Conclusion The high level of miR-27b can predict the occurrence of ACAS, and is closely related to the subsequent occurrence of CIEs. The present results provide evidence for circulating miR-27b as a diagnostic and prognostic marker in patients with ACAS.

show abstract

Severe carotid artery stenosis evaluated by ultrasound is associated with post stroke vascular cognitive impairment

Cited by 18 publications

References 43 publications

Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation

Brain Functional Network in Chronic Asymptomatic Carotid Artery Stenosis and Occlusion: Changes and Compensation

Tek Taraflı Karotis Arter Stenozunda Diabetik Retinopati

Circulating miR-27b as a Biomarker of the Development and Progression of Carotid Artery Stenosis

Contact Info

Product

Resources

About