Combretum micranthum G. Don protects hypertension induced by L-NAME by cardiovascular and renal remodelling through reversing inflammation and oxidative stress

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

“…The study carried out by Kpemissi (2022) also revealed the substantial antihypertensive potential of C. micranthum extract [72] …”

“…Currently, 15 fatty acids (65-79) have been identified in the leaves and seeds of C. micranthum, including 7 saturated (65-71) and 8 unsaturated (72)(73)(74)(75)(76)(77)(78)(79). All of these fifteen compounds are found in the seeds and only seven (65-67, 71, 75-77) in the leaves.…”

“…[71] The study carried out by Kpemissi (2022) also revealed the substantial antihypertensive potential of C. micranthum extract. [72] Mashi et al (2023) reported that the aqueous extract of C. micranthum leaves exhibited in vitro inhibitory activity against angiotensin converting enzyme comparable to captopril. [36] 4.6.…”

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

“…Catechin [96] ↑ GSH and the GSH2/GSSG ratio [94] Stigmasterol, betulinic acid [97] ↓ lipid peroxidation Antihemolytic effect ↓ blood pressure ↓ kidney hypertrophy ↑ CAT and SOD in the kidney [95] Hyperoside, quercitrin, caftaric acid, gentisic acid, caffeic acid and chlorogenic acid [99] ↓ blood pressure ↓ blood levels of uric acid, urea, creatinine, and urine levels of NAG ↓ TNF-α [99] Gallic acid, catechin, epicatechin, rutin, quercetin, and kaempferol [100] ↓ plasma concentrations of ALT, AST, and ALP ↑ SOD ↓ MDA, NO, and APOP ↑ catalase and SOD [100] Caffeic acid, chlorogenic acid, anthocyanins, p-coumaric acid, ferulic acid, o-coumaric acid, quercetin, gallic acid, rutin, catechin [98] ↓ CRP The activity of SOD and catalase enzymes, as well as the concentration of MDA, did not differ from the placebo group [101] Epigallocatechin, catechin, and epicatechin gallate [102] ↓ fibrinogen levels, protein expression of p22phox, and hsCPR…”

Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

“…Combretum micranthum (CM) commonly called Kinkeliba is an African medicinal plant with several ethnopharmacological activities ( Kpemissi et al, 2019b ). Our previous research work highlights this plant as a potential source of renoprotective compounds in different nephrotoxicity models ( Kpemissi et al, 2022 , Kpemissi et al, 2019a ; Kpemissi et al, 2020b , Kpemissi et al, 2020a ). Phytochemical and in silico screening revealed that CM extract contains flavonoids that inhibit nuclear factor kappa B and soluble epoxide hydrolase ( Kpemissi et al, 2019a ) while stimulating peroxisome proliferator-activated receptors alpha and gamma ( Kpemissi et al, 2020b ), which are potential targets in neuroprotection ( Certo et al, 2015 , Wang et al, 2018 , Xie et al, 2020 ).…”