Combined use of chemical and biological compounds to control hookworm

Abstract

The aim of this study was to evaluate the combined use of different chemical (albendazole, ivermectin, glycerine and Vaseline) and biological (Monacrosporium thaumasium) compounds in the control of Ancylostoma caninum. Infective larvae of A. caninum were obtained from coprocultures of positive faeces from naturally infected dogs. We used 1% ivermectin, 1% albendazole, 100% glycerine, 100% Vaseline and an isolate of the nematophagous fungus M. thaumasium (NF34), alone or in combinations. Next, an experimental test was set up with 16 groups in microtubes, with a 24-h interaction. The groups (G1 to G15) that contained any chemical or biological compound (NF34) and/or their combined use (chemical + biological) showed a difference in relation to the control group, except G5 – Vaseline 100% without combinations. It was concluded that, even on an experimental basis, the combined use of anthelmintic drugs with biological control was efficient; however, more studies must be carried out in order to elucidate the synergistic action between chemical and biological compounds to be used in the effective control of hookworms in the future.

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

“…Nonetheless, common disinfectants have limitations of effectiveness on other surfaces, such as sandy soils and lawns [85,86]. Research with the purpose of promoting integrative control measures, through the association of chemical and biological control, has been developed and demonstrated satisfactory results [3,9,40,80,87,88]. Research should be encouraged to evaluate the associated use of helminthophagous fungi and common disinfectants, enabling their associated use in doses that do not cause fungal inhibition, increasing the use of these fungi.…”

Ovicidal Activity of Chemical Disinfectants and the Nematophagous Fungus Duddingtonia flagrans and Toxocara canis

“…In the case of geohelminths, although disinfectants such as sodium hypochlorite 2% and benzalkonium chloride be considered as effective, their use is limited on impermeable surfaces such as concrete or ceramic floors [5]. Thus, the application of nematophagous fungi may be as a viable control strategie [6], mainly in sandy and permeable soils. In the environment, Duddingtonia flagrans produces traps that capture and fixate these nematodes and later destroy their internal structures [7].…”