Combined mesenchymal sarcoma and carcinoma (carcinosarcoma) of the uterus

Hill, Robert P.; Miller, Frank Nelson

doi:10.1002/1097-0142(195107)4:4<803::aid-cncr2820040417>3.0.co;2-m

Cited by 33 publications

(2 citation statements)

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“…It has been proposed that stem cell precursors present in pluripotent ovarian surface epithelium and/or subcapsular stroma give rise to the epithelial and mesenchymal cells comprising these tumors (6,7). Numerous theories have been postulated to account for the simultaneous development of multiple malignant elements (13,21,26). The collision theory suggests that the independent sarcomatous and carcinomatous cell populations present within mixed mullerian tumors are derived from separate primary sites.…”

Section: Introductionmentioning

confidence: 99%

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Cytogenetic, morphologic and oncogene analysis of a cell line derived from a heterologous mixed mullerian tumor of the ovary

Becker

Papenhausen

Widen

1997

In Vitro Cell.Dev.Biol.-Animal

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A cell line was established from a mixed mullerian tumor of the ovary and designated LN1. Histopathologic analysis of the fresh tumor specimen demonstrated a highly aneuploid heterologous tumor comprised of undifferentiated mesodermal components with carcinomatous cells present as a smaller population. Long-term in vitro culture resulted in the establishment of a cell line that exhibits an epithelial-like morphology and expresses epithelial antigens cytokeratin, epithelial membrane antigen, and carcinoma antigen TAG-72. These cells also express mesenchymal intermediate filaments, vimentin, and desmin. Karyotypic analysis revealed a basic triploid pattern with multiple chromosomal abnormalities, most notably an isochromosome of the short arm of five present in three copies. Analysis of oncogene expression revealed that LN1 cells constitutively express mRNA for c-ras, c-erbB2, and p53. The expression of mRNA for cellular oncogenes correlated with the presence of corresponding oncoproteins, p21H-ras, p21K-ras, and p185erB2 and mutant p53 protein. In summary, coexpression of epithelial and mesenchymal antigens by LN1 cells lends support to the hypothesis that epithelial and mesenchymal elements comprising mixed mullerian tumors of the ovary are derived from a common stem cell precursor. Furthermore, this cell line represents a functional in vitro model to evaluate the biologic activities of these unusual and highly aggressive ovarian malignancies.

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Section: Introductionmentioning

confidence: 99%

“…Jan duct derivation are present, including leiomyosarcoma. Ahernatively, these tumors may be heterologous with sarcomatous cells exhibiting differentiation extrinsic to mullerian origin, such as chondrosarcoma, liposarcoma, osteosarcoma, and rhabdomyosarcoma (5,6,12,13,21,26,30).…”

Section: Introductionmentioning

confidence: 99%