Combined image-processing algorithms for improved optical coherence tomography of prostate nerves

Chitchian, Shahab; Weldon, Thomas P.; Fiddy, Michael A.; Fried, Nathaniel M.

doi:10.1117/1.3481144

Cited by 18 publications

(1 citation statement)

References 25 publications

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“…OCT has also been described for prostatic nerve identification in order to spare them during radical prostatectomy experiments. 33,34 Dangle et al 35 evaluated surgical margins, seminal vesicle invasion, and capsular invasion with OCT ex vivo in prostates after radical prostatectomy. They found that OCT overestimated the amount of margin involvement, but the Fig.…”

Section: Perspective To Other Work In the Fieldmentioning

confidence: 99%

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

et al. 2018

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Diagnostic accuracy of needle-based optical coherence tomography (OCT) for prostate cancer detection by visual and quantitative analysis is defined. 106 three-dimensional (3-D)-OCT data sets were acquired in 20 prostates after radical prostatectomy and precisely matched with pathology. OCT images were grouped per histological category. Two reviewers performed blind assessments of the OCT images. Sensitivity and specificity for malignancy detection were calculated. Quantitative analyses by automated optical attenuation coefficient calculation were performed. OCT can reliably differentiate between fat, cystic, and regular atrophy and benign glands. The overall sensitivity and specificity for malignancy detection was 79% and 88% for reviewer 1 and 88% and 81% for reviewer 2. Quantitative analysis for differentiation between stroma and malignancy showed a significant difference (4.6 mm - 1 versus 5.0 mm - 1 Mann-Whitney U-test p < 0.0001). A Kruskal-Wallis test showed a significant difference in median attenuation coefficient between stroma, inflammation, Gleason 3, and Gleason 4 (4.6, 4.1, 5.9, and 5.0 mm - 1, respectively). However, attenuation coefficient varied per patient and a related-samples Wilcoxon signed-rank test showed no significant difference per patient (p = 0.17). This study confirmed the one to one correlation of histopathology and OCT. Precise matching showed that most histological tissues categories in the prostate could be distinguished by their unique pattern in OCT images. In addition, the optical attenuation coefficient can play a role in the differentiation between stroma and malignancy; however, a per patient analysis of the optical attenuation coefficient did not show a significant difference.

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Section: Perspective To Other Work In the Fieldmentioning

confidence: 99%

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

et al. 2018

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Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

Muller

Bruin

Brandt

et al. 2016

Journal of Biophotonics

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The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm(-1) ; 3.85 mm(-1) ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor was visible in two subsequent histopathological prostate slices. This analysis could be performed in 3 patients. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.23 mm(-1) ; 4.11 mm(-1) ; p < 0.0001) for all patients grouped together. The area under the ROC curve was 0.89. Functional OCT of the prostate has shown to differentiate between cancer and healthy prostate tissue. The optical attenuation coefficient in malignant tissue was significantly higher in malignant tissue compared to benign prostate tissue. Further studies are required to validate these initial results in a larger group of patients with a more tailored histopathology matching protocol.

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Advanced intraoperative imaging methods for laparoscopic anatomy navigation: an overview

et al. 2012

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Implementation of new optical imaging methods during laparoscopic gastrointestinal surgery can improve intraoperative anatomy navigation. This may lead to increased patient safety (preventing iatrogenic functional tissue injury) and procedural efficiency (shorter operating time). Near-infrared fluorescence imaging seems to possess the greatest potential for implementation in clinical practice in the near future.

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Combined image-processing algorithms for improved optical coherence tomography of prostate nerves

Cited by 18 publications

References 25 publications

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

Needle-based optical coherence tomography for the detection of prostate cancer: a visual and quantitative analysis in 20 patients

Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

Advanced intraoperative imaging methods for laparoscopic anatomy navigation: an overview

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