Advanced intraoperative imaging methods for laparoscopic anatomy navigation: an overview

Abstract

Implementation of new optical imaging methods during laparoscopic gastrointestinal surgery can improve intraoperative anatomy navigation. This may lead to increased patient safety (preventing iatrogenic functional tissue injury) and procedural efficiency (shorter operating time). Near-infrared fluorescence imaging seems to possess the greatest potential for implementation in clinical practice in the near future.

Application of a New Dye for Near-Infrared Fluorescence Laparoscopy of the Ureters

“…an advanced intraoperative imaging method, called near-infrared fluorescence imaging, can be applied for real-time fluorescence ureteral guidance after intravenous administration of a fluorophore. 5 at this moment, the only clinically available dye for this purpose is methylene blue. a more recently described near-infrared fluorophore, CW800-Ca, is another fluorophore that is excreted in urine.…”

Near-Infrared Fluorescence Laparoscopy of the Cystic Duct and Artery in Pigs: Performance of a Preclinical Dye

“…4 Several clinical pilot studies have demonstrated its usefulness and feasibility for real-time intraoperative identification of extrahepatic bile ducts and arteries to assist in safe and timeefficient gallbladder removal. However, this new technique needs optimization with respect to imaging systems and injected fluorophores.…”

Near‐Infrared Fluorescence Imaging for Real‐Time Intraoperative Anatomical Guidance in Minimally Invasive Surgery: A Systematic Review of the Literature

“…Various values have been reported in the literature [1,12], with a maximum penetration depth found of 10 mm in fatty tissue. Novel fluorescent dyes and dedicated NIRF imaging systems are needed to improve penetration depth, as in surgery essential structures are not seldom covered by a layer of C10 mm fatty tissue.…”