Near‐Infrared Fluorescence Imaging for Real‐Time Intraoperative Anatomical Guidance in Minimally Invasive Surgery: A Systematic Review of the Literature

Schols, Rutger M.; Connell, Niels J.; Stassen, Laurents P. S.

doi:10.1007/s00268-014-2911-6

Cited by 78 publications

(60 citation statements)

References 95 publications

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“…These NIR laser-activated "bomb-like" HLPP-IAR nanoparticles demonstrate superior in vitro and in vivo effi cacy against the CSCs. Although the tissue penetration of the NIR is limited to less than ≈1 cm and multiple polymers are needed for preparing the nanosystem, NIR could be delivered into deep tissue using minimally invasive approaches [ 13 ] and the prepar ation of the nanosystem using the double-emulsion method is quite straightforward (Scheme 1 A). Therefore, the present study demonstrates the great potential of the NIR laseractivated "nanobomb" for microRNA delivery to achieve augmented cancer therapy.…”

Section: Communicationmentioning

confidence: 99%

A Near‐Infrared Laser‐Activated “Nanobomb” for Breaking the Barriers to MicroRNA Delivery

et al. 2015

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Section: Communicationmentioning

confidence: 99%

A Near‐Infrared Laser‐Activated “Nanobomb” for Breaking the Barriers to MicroRNA Delivery

et al. 2015

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“…Although the use of indocyanine green may increase detection rates in obese women as it allows for surgeons to “see through” adipose tissue, near infrared imaging technology can only achieve a penetration depth of 1 cm. [21] With such minimal penetration depth, identification of sentinel nodes using indocyanine green and near infrared imaging remains challenging in obese and morbidly obese women.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer

Salvo

Ramírez

Levenback

et al. 2017

Gynecologic Oncology

162

116

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Objective The role of sentinel lymph node (SLN) biopsy alone for staging of early-stage cervical cancer remains controversial. We aimed to determine the validity of this technique in women with early-stage cervical cancer. Methods We retrospectively reviewed women with early-stage cervical cancer who underwent SLN mapping followed by complete pelvic lymphadenectomy as part of initial surgical management from August 1997 through October 2015. All modes of surgical approach were included. Lymphatic mapping was performed using blue dye, technetium-99m sulfur colloid (Tc-99), and/or indocyanine green (ICG). We determined SLN detection rates, sensitivity and negative predictive value. Results One hundred eighty-eight patients were included, and 35 (19%) had lymph node metastases. At least one SLN was identified in 170 patients (90%), and bilateral SLNs were identified in 117 patients (62%). The majority of SLNs (83%) were found in the pelvis. There was no difference in detection rates between mapping agents, surgical approach, patients with and without prior conization or between patients with tumors < 2 cm and ≥ 2 cm. The detection rate for bilateral SLNs was significantly lower in women with body mass index (BMI) > 30 kg/m2 than in women with lower BMI (p=0.03). Metastatic disease in sentinel nodes was detected by H&E staining in 78% of cases and required ultrastaging/immunohistochemistry in 22% of cases. Only one patient had a false-negative result, yielding a sensitivity of 96.4% (95% CI 79.8%–99.8%) and negative predictive value of 99.3% (95% CI 95.6%–100%). The false-negative rate was 3.6%. Conclusions In these women with early-stage cervical cancer, SLN biopsy had very high sensitivity and negative predictive value. We believe it is time to change the standard of care for women with early-stage cervical cancer to SLN biopsy only.

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“…It is exclusively removed by the liver and excreted through the bile without being metabolized. NIR fluorescence imaging is capable of a penetration depth of up to 1 cm in tissue (12). Therefore, a thorough dissection to reach the lymphatic tissue is required to identify lymph channels and nodes with dye uptake.…”

Section: Discussionmentioning

confidence: 99%

Impact of Obesity on Sentinel Lymph Node Mapping in Patients with Newly Diagnosed Uterine Cancer Undergoing Robotic Surgery

et al. 2016

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Purpose To determine the impact of obesity on the rate of successful sentinel lymph node (SLN) mapping in patients with uterine cancer undergoing robotic surgery, and compare SLN detection rates using indocyanine green (ICG) versus blue dye. Methods We reviewed robotic cases undergoing SLN mapping with a cervical injection from 1/2011–12/2013 using either blue dye or ICG with near-infrared (NIR) fluorescence imaging. Data were stratified by body mass index (BMI) and dye used. Appropriate statistical tests were applied. Results Four hundred seventy-two cases were identified. Bilateral mapping was successful in 352 cases (75%), unilateral mapping in 73 cases (15%). Bilateral mapping was achieved in 266 (85%) of 312 ICG cases compared with 86 (54%) of 160 blue dye cases (p<0.001). Cases with successful bilateral mapping had a median BMI of 29.8 kg/m2 (range, 16.3–65.3 kg/m2); cases with no mapping had a median BMI of 34.7 kg/m2 (range, 21.4–60.4 kg/m2) (p=0.001). With increasing BMI, there was a significant decrease in successful bilateral mapping rates for both the ICG (p<0.001) and blue dye groups (p=0.041). However, the use of ICG resulted in better bilateral (p=0.002) and overall (p=0.011) mapping rates compared with the use of blue dye in all BMI groups. Conclusions ICG results in a higher overall and bilateral SLN detection than blue dye in women with uterine cancer. Successful mapping decreases with increasing BMI irrespective of dye used; however, it is significantly improved with the use of ICG and NIR fluorescence imaging compared to blue dye.

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Near‐Infrared Fluorescence Imaging for Real‐Time Intraoperative Anatomical Guidance in Minimally Invasive Surgery: A Systematic Review of the Literature

Cited by 78 publications

References 95 publications

A Near‐Infrared Laser‐Activated “Nanobomb” for Breaking the Barriers to MicroRNA Delivery

A Near‐Infrared Laser‐Activated “Nanobomb” for Breaking the Barriers to MicroRNA Delivery

Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer

Impact of Obesity on Sentinel Lymph Node Mapping in Patients with Newly Diagnosed Uterine Cancer Undergoing Robotic Surgery

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