2017
DOI: 10.1016/j.ygyno.2017.02.005
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Abstract: Objective The role of sentinel lymph node (SLN) biopsy alone for staging of early-stage cervical cancer remains controversial. We aimed to determine the validity of this technique in women with early-stage cervical cancer. Methods We retrospectively reviewed women with early-stage cervical cancer who underwent SLN mapping followed by complete pelvic lymphadenectomy as part of initial surgical management from August 1997 through October 2015. All modes of surgical approach were included. Lymphatic mapping was… Show more

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Cited by 152 publications
(124 citation statements)
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References 27 publications
(31 reference statements)
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“…In patients with early-stage cervical cancer, SLN biopsy is purported to be a sensitive method for detecting lymph node involvement, especially if the SLN is detected bilaterally,1 8 with a high sensitivity and a negative predictive value of 99% 9. According to a review by Tax,10 the false-negative rate is considered very low, with a residual risk of occult metastases of 0.08% in non-sentinel lymph nodes in cases of no suspicious lymph nodes on pre-operative imaging or during surgery, and bilateral negative SLN after ultrastaging.…”
Section: Introductionmentioning
confidence: 99%
“…In patients with early-stage cervical cancer, SLN biopsy is purported to be a sensitive method for detecting lymph node involvement, especially if the SLN is detected bilaterally,1 8 with a high sensitivity and a negative predictive value of 99% 9. According to a review by Tax,10 the false-negative rate is considered very low, with a residual risk of occult metastases of 0.08% in non-sentinel lymph nodes in cases of no suspicious lymph nodes on pre-operative imaging or during surgery, and bilateral negative SLN after ultrastaging.…”
Section: Introductionmentioning
confidence: 99%
“…22 In fact, a number of centers have turned to a practice of sentinel lymph node mapping alone in patients undergoing surgery with early-stage cervical cancer. 23,24 One major drawback in proposing a plan in such lowrisk patients is that the LVSI status is often not known prior to the planned surgery. In this sense, 1 study observed that hysterectomy specimen had higher sensitivity and negative predictive value in comparison with cervical biopsy, conization, and loop electrosurgical procedure (LEEP) in determining LVSI.…”
Section: Discussionmentioning
confidence: 99%
“…Most significantly, the rate of detection of LN metastases increases, and the false negative rate decreases when SLNs are detected bilaterally. For that reason, a side‐specific LN dissection is undertaken in patients with unilateral mapping . Additionally, there is some evidence supporting lower false negative rates by limiting the use of SLN mapping to tumours <4 cm, although the NCCN guidelines note that mapping results are optimised in tumours <2 cm .…”
Section: Cervixmentioning
confidence: 99%
“…Negative SLNs serve as surrogate markers of negative LNs along the entire path of lymphatic drainage. Validation studies that included completion lymphadenectomy report false negative rates for SLNs at all gynaecological sites of less than 5% . Clinical and pathological aspects specific to each gynaecological site are discussed below.…”
Section: Introductionmentioning
confidence: 99%