Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators

Alvarenga-Filho, Hélcio; Sacramento, Priscila M.; Ferreira, Thaís B.; Hygino, Joana; Abreu, Jorge Eduardo Canto; Carvalho, Sónia; Wing, Ana Cristina; Alvarenga, Regina Maria Papais; Bento, Cleonice A.M.

doi:10.1016/j.jneuroim.2016.02.014

Cited by 57 publications

(63 citation statements)

References 49 publications

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“…Furthermore, exercise diminishes the number of CD4+ and CD8+ T‐cells in both SVF and splenocytes (Kawanishi et al ., ). Exercise effects on T cell populations and cytokine secretion may be mediated through increased catecholamine secretion (Alvarenga‐Filho et al ., ; Kruger et al ., ). High intensity interval training (Rao et al ., ) in lean subjects increases the mobilization of the anti‐inflammatory regulatory T cells (Tregs) (Kruger et al ., ), as treatment of cultured human T‐cells with catecholamine reduced their secretion of inflammatory cytokines (TNF‐α, IL‐6, IL‐17, IL‐21 and IL‐22) (Alvarenga‐Filho et al ., ).…”

Section: Introductionmentioning

confidence: 99%

“…Exercise effects on T cell populations and cytokine secretion may be mediated through increased catecholamine secretion (Alvarenga‐Filho et al ., ; Kruger et al ., ). High intensity interval training (Rao et al ., ) in lean subjects increases the mobilization of the anti‐inflammatory regulatory T cells (Tregs) (Kruger et al ., ), as treatment of cultured human T‐cells with catecholamine reduced their secretion of inflammatory cytokines (TNF‐α, IL‐6, IL‐17, IL‐21 and IL‐22) (Alvarenga‐Filho et al ., ). Furthermore, exercise prevents TCD4+ and TCD8+ apoptosis, by increasing telomere length and decreasing annexin V, a marker of apoptosis (Silva et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Boa

Yudkin

Hinsbergh

et al. 2017

British J Pharmacology

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Obesity is a global epidemic, accompanied by increased risk of type 2 diabetes and cardiovascular disease. Adipose tissue hypertrophy is associated with adipose tissue inflammation, which alters the secretion of adipose tissue‐derived bioactive products, known as adipokines. Adipokines determine vessel wall properties such as smooth muscle tone and vessel wall inflammation. Exercise is a mainstay of prevention of chronic, non‐communicable diseases, type 2 diabetes and cardiovascular disease in particular. Aside from reducing adipose tissue mass, exercise has been shown to reduce inflammatory activity in this tissue. Mechanistically, contracting muscles release bioactive molecules known as myokines, which alter the metabolic phenotype of adipose tissue. In adipose tissue, myokines induce browning, enhance fatty acid oxidation and improve insulin sensitivity. In the past years, the perivascular adipose tissue (PVAT) which surrounds the vasculature, has been shown to control vascular tone and inflammation through local release of adipokines. In obesity, an increase in mass and inflammation of PVAT culminate in dysregulation of adipokine secretion, which contributes to vascular dysfunction. This review describes our current understanding of the mechanisms by which active muscles interact with adipose tissue and improve vascular function. Aside from the exercise‐dependent regulation of canonical adipose tissue function, we will focus on the interactions between skeletal muscle and PVAT and the role of novel myokines, such as IL‐15, FGF21 and irisin, in these interactions. Linked Articles This article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue – Potential Pharmacological Targets? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Boa

Yudkin

Hinsbergh

et al. 2017

British J Pharmacology

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“…There is further speculation that exercise training may have disease modifying effects for persons with MS (Motl and Pilutti, 2012;Zimmer et al, 2017), and this is largely based on initial evidence for exercise training effects on relapses, brain atrophy and disability progression. Researchers recently suggested a renewed focus regarding the effects of exercise training on cytokines and adipokines based, in part, on the potential for MS disease modification (Alvarenga-Filho et al, 2016;Bansi et al, 2013;Briken et al, 2016;Kjølhede et al, 2016;Mokhtarzade et al, 2017). This renewed focus is further based on evidence for exercise training effects on markers of immune system function in the general populations of adults (Gjevestad et al, 2015;Gondim et al, 2015).…”

mentioning

confidence: 99%

Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review

Negaresh

Motl

Mokhtarzade

et al. 2018

Multiple Sclerosis and Related Disorders

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“…Recently, Alvarenga et al, [99] measured significantly lower levels of the type 2 cytokine IL-22 following a 12 week combined resistance and aerobic protocol for patients with multiple sclerosis. The cytokine, IL-22 remains to be evaluated in response to exercise at different intensities for healthy participants [99].…”

Section: Exercise and The Mobilization Of Ilcsmentioning

confidence: 99%

“…The cytokine, IL-22 remains to be evaluated in response to exercise at different intensities for healthy participants [99]. Furthermore, other sources of IL-22 (i.e., type 3 ILCs) need to be explored as the current literature only recognized the cytokine in context to being released from a TH17 response.…”

Section: Exercise and The Mobilization Of Ilcsmentioning

confidence: 99%

The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair

Jones¹,

Hoyne²

2017

J Clin Cell Immunol

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The immune system plays a crucial role in regulating tissue repair processes following damage. The cellular basis of tissue repair has best been studied in toxin-induced models due to their reliability and reproducible kinetics. These models have established a crucial role for innate and adaptive immune cells that follow a temporally regulated response that begins with a proinflammatory response that is subsequently replaced by a regulatory type 2 immune response to facilitate tissue repair and restore homeostasis. Inflammation is a crucial first response to cell damage that is modulated by the response of innate lymphoid cells and tissue resident regulatory T cells. In this review we examine the process of exercise induced muscle damage to provide comparisons of how this may follow a similar coordinated response as that mediated by toxin induced damage.

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Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators

Cited by 57 publications

References 49 publications

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Effects of exercise training on cytokines and adipokines in multiple Sclerosis: A systematic review

The Role of the Innate and Adaptive Immunity in Exercise Induced Muscle Damage and Repair

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