Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Boa, B.C.S.; Yudkin, JS; Hinsbergh, Victor W.M. van; Bouskela, Eliete; Eringa, Etto C.

doi:10.1111/bph.13732

Cited by 61 publications

(52 citation statements)

References 152 publications

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“…Also AT expresses FGF21 which might be implicated in CVD since it is associated with cardio-metabolic risk factors, increased intima-media thickness of carotid and iliac arteries, high levels of C-reactive protein, dysglycemia, dyslipidemia, and decreased adiponectin levels (129,130). As for IL-6, the existence of different tissue sources of FGF21 suggests tissue-specific physiological functions (131).…”

Section: Fibroblast Growth Factor 2 (Fgf2) and Fgf21mentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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Abstract:In the last few years, a growing number of molecules have been associated to an endocrine function of the skeletal muscle. Circulating myokine levels, in turn, have been associated with several pathophysiological conditions including the cardiovascular ones. However, data from different studies are often not completely comparable or even discordant. This would be due, at least in part, to the whole set of situations related to the preparation of the patient prior to blood sampling, blood sampling procedure, processing and/or store. This entire process constitutes the pre-analytical phase. The importance of the preanalytical phase is often not considered. However, in routine diagnostics, the 70% of the errors are in this phase. Moreover, errors during the pre-analytical phase are carried over in the analytical phase and affects the final output. In research, for example, when samples are collected over a long time and by different laboratories, a standardized procedure for sample collecting and the correct procedure for sample storage are acknowledged. In this review, we discuss the pre-analytical variables potentially affecting the measurement of myokines with cardiovascular functions.

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Section: Fibroblast Growth Factor 2 (Fgf2) and Fgf21mentioning

confidence: 99%

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Lombardi¹,

Sansoni²,

Banfi³

2017

Ann. Transl. Med.

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“…which poses a great challenge to human health. 12,13 Accompanying obesity, the crosstalk between adipose and cancer-prone cells may occur via obesity-associated hormones, cytokines and other mediators and finally results in increased cancer risk and/or progression, 14 which has started to gather more and more attention. 15,16 For example, Wolin et al reported that 20% of cancer patients was attributable to excess body weight.…”

mentioning

confidence: 99%

Notch3 promotes 3T3‐L1 pre‐adipocytes differentiation by up‐regulating the expression of LARS to activate the mTOR pathway

Guo

Tan

Xiong

et al. 2019

J Cellular Molecular Medi

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Adipocytes constitute a major component of the tumour microenvironment. Numerous studies have shown that adipocytes promote aggressiveness and invasion by stimulating cancer cells proliferation and modulating their metabolism. Herein, we reported that Notch3 promotes mouse 3T3‐L1 pre‐adipocytes differentiation by performing the integrative transcriptome and TMT‐based proteomic analyses. The results revealed that aminoacyl‐tRNA_biosynthesis pathway was significantly influenced with Nocth3 change during 3T3‐L1 pre‐adipocytes differentiation, and the expression of LARS in this pathway was positively correlated with Notch3. Published studies have shown that LARS is a sensor of leucine that regulates the mTOR pathway activity, and the latter involves in adipogenesis. We therefore supposed that Notch3 might promote 3T3‐L1 pre‐adipocytes differentiation by up‐regulating LARS expression and activating mTOR pathway. CHIP and luciferase activity assay uncovered that Notch3 could transcriptionally regulate the expression of LARS gene. Oil Red staining identified a positive correlation between Notch3 expression and adipocytic differentiation. The activation of mTOR pathway caused by Notch3 overexpression could be attenuated by knocking down LARS expression. Altogether, our study revealed that Notch3 promotes adipocytic differentiation of 3T3‐L1 pre‐adipocytes cells by up‐regulating LARS expression and activating the mTOR pathway, which might be an emerging target for obesity treatment.

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“…Also, utilizing the PVAT FAI may help to assess the efficacy of novel therapeutics to inhibit vascular inflammation and improve cardiovascular mortality and morbidity. Furthermore, studies in mice suggest that exercise and brown adipocyte inducers such as cold exposure and pharmacological β-adrenergic stimulation can enhance the protective effects of PVAT on vascular function through PVAT browning [51,52]. While this is an attractive potential strategy to improve PVAT function, more studies are required to understand the therapeutic implications and to validate these findings in humans.…”

Section: Discussionmentioning

confidence: 99%

Potential role of perivascular adipose tissue in modulating atherosclerosis

2020

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Perivascular adipose tissue (PVAT) directly juxtaposes the vascular adventitia and contains a distinct mixture of mature adipocytes, preadipocytes, stem cells, and inflammatory cells that communicate via adipocytokines and other signaling mediators with the nearby vessel wall to regulate vascular function. Cross-talk between perivascular adipocytes and the cells in the blood vessel wall is vital for normal vascular function and becomes perturbed in diseases such as atherosclerosis. Perivascular adipocytes surrounding coronary arteries may be primed to promote inflammation and angiogenesis, and PVAT phenotypic changes occurring in the setting of obesity, hyperlipidemia etc., are fundamentally important in determining a pathogenic versus protective role of PVAT in vascular disease. Recent discoveries have advanced our understanding of the role of perivascular adipocytes in modulating vascular function. However, their impact on cardiovascular disease (CVD), particularly in humans, is yet to be fully elucidated. This review will highlight the complex mechanisms whereby PVAT regulates atherosclerosis, with an emphasis on clinical implications of PVAT and emerging strategies for evaluation and treatment of CVD based on PVAT biology.

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Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Cited by 61 publications

References 152 publications

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Notch3 promotes 3T3‐L1 pre‐adipocytes differentiation by up‐regulating the expression of LARS to activate the mTOR pathway

Potential role of perivascular adipose tissue in modulating atherosclerosis

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