Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus

Tousoulis, Dimitris; Koniari, Katerina; Antoniades, Charalambos; Papageorgiou, Nikolaos S.; Miliou, Antogoni; Noutsou, Marina; Nikolopoulou, Aggeliki; Marinou, Kyriakoula; Stefanadi, Elli; Siasos, Gerasimos; Charakida, Marietta; Kamboli, Anna Maria; Stefanadis, Christodoulos

doi:10.1016/j.ijcard.2009.11.038

Cited by 27 publications

(13 citation statements)

References 33 publications

(27 reference statements)

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“…11 Pharmacological interaction of metformin and statin is described, 40 resulting in reduced levels of TNF-α compared with metformin use alone. 41 Adding the interaction term of metformin and statins to the model did not substantially change our results, in the metformin and statin analyses. The similarity of the effects of metformin and statins possibly point to some yet unknown, shared biochemical mechanism of action or a similar influence on glycosyltransferases or glycosidases in the N-glycosylation machinery which warrants further detailed studies.…”

Section: Discussionmentioning

confidence: 59%

Metformin and statin use associate with plasma proteinN-glycosylation in people with type 2 diabetes

Singh

Naber

Dotz

et al. 2020

BMJ Open Diab Res Care

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IntroductionRecent studies revealed N-glycosylation signatures of type 2 diabetes, inflammation and cardiovascular risk factors. Most people with diabetes use medication to reduce cardiovascular risk. The association of these medications with the plasma N-glycome is largely unknown. We investigated the associations of metformin, statin, ACE inhibitor/angiotensin II receptor blocker (ARB), sulfonylurea (SU) derivatives and insulin use with the total plasma N-glycome in type 2 diabetes.Research design and methodsAfter enzymatic release from glycoproteins, N-glycans were measured by matrix-assisted laser desorption/ionization mass spectrometry in the DiaGene (n=1815) and Hoorn Diabetes Care System (n=1518) cohorts. Multiple linear regression was used to investigate associations with medication, adjusted for clinical characteristics. Results were meta-analyzed and corrected for multiple comparisons.ResultsMetformin and statins were associated with decreased fucosylation and increased galactosylation and sialylation in glycans unrelated to immunoglobulin G. Bisection was increased within diantennary fucosylated non-sialylated glycans, but decreased within diantennary fucosylated sialylated glycans. Only few glycans were associated with ACE inhibitor/ARBs, while none associated with insulin and SU derivative use.ConclusionsWe conclude that metformin and statins associate with a total plasma N-glycome signature in type 2 diabetes. Further studies are needed to determine the causality of these relations, and future N-glycomic research should consider medication a potential confounder.

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Section: Discussionmentioning

confidence: 59%

Metformin and statin use associate with plasma proteinN-glycosylation in people with type 2 diabetes

Singh

Naber

Dotz

et al. 2020

BMJ Open Diab Res Care

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“…Elevated levels of hs-CRP have been shown to be predictive of an increased risk of coronary heart disease in apparently healthy adults, as the hs-CRP is increased in patients with coronary heart disease, ischemia, and heart attack [54]. Indeed, it has been suggested that CRP contributes to the development of atherosclerosis, since its binding to modified LDL molecules within atherosclerotic plaques activates the complement which then promotes the development of lesions [5].…”

Section: Anti-inflammatory Effects Of Statinsmentioning

confidence: 99%

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

Diamantis

Kyriakos

Quiles-Sánchez

et al. 2017

CCR

168

108

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Background:Statins have long been used for the protection against coronary artery disease (CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic properties. Emerging evidence from laboratory studies and clinical trials as well have pointed out the pivotal role of inflammation on the initiation and exacerbation of atherosclerosis; a major cause of CAD. Inflam-mation markers such as high sensitivity C-reactive protein and adhesion molecules are shown to in-crease in CAD patients and are used as prognostic tools. It is well known that statins can actually re-duce the circulating levels of these agents slowing therefore the inflammatory process; interestingly not all types have the same outcome.Conclusion:The anti-inflammatory effect of statins on the formation of atherosclerotic plaque and the function of endothelial cells is thus of particular importance as these agents can actually ameliorate CAD prognosis

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“…Several known risk factors, including hyperglycemia, dyslipidemia, and insulin resistance which characterizes T2DM, acts in concert to target endothelial cells, resulting in oxidative stress and endothelial dysfunction [6]. The combined administration of metformin together with atorvastatin ameliorates inflammation in patients with T2DM [7]. C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease [8].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus

Papaoikonomou¹,

Tousoulis²,

Tentolouris³

et al. 2015

J Diabetes Metab

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Objective: Diabetes mellitus is strongly associated with inflammatory procedures, obesity and macrovascular complications, while genetic factors are involved in the disease pathogenesis and its complications. The aim of this study was to examine the impact of A3872G polymorphism on C-reactive protein (CRP) gene on the prevalence of peripheral arterial disease (PAD) in Greek Caucasian subjects with type 2 diabetes mellitus (T2DM). Methods:The study population consisted of 423 patients with T2DM. The A3872G polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme digestion (HpyCH4III). High sensitivity CRP was assayed by particle-enhanced immunonephelometry. PAD was diagnosed using clinical or ultrasonography criteria and/or ankle brachial index <0.9. Results:The genotype distribution (%) in PAD patients (GG: 48.

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Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus

Cited by 27 publications

References 33 publications

Metformin and statin use associate with plasma proteinN-glycosylation in people with type 2 diabetes

Metformin and statin use associate with plasma proteinN-glycosylation in people with type 2 diabetes

The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature

Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus

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