Combinatorial effect of plasma treatment, fiber alignment and fiber scale of poly (ε-caprolactone)/collagen multiscale fibers in inducing tenogenesis in non-tenogenic media

Sankar, Deepthi; Mony, Ullas; Rangasamy, Jayakumar

doi:10.1016/j.msec.2021.112206

Cited by 19 publications

(10 citation statements)

References 78 publications

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“…Arranged PCL/Col multiscale fibers can mimic the tendon matrix and enhance porosity by sacrificing collagen nano fibers. Plasma treatment with argon and nitrogen enhances the roughness and hydrophilicity of the fibers, which can significantly enhance cell adhesion and proliferation, and induce tendon differentiation of MSCs [ 78 ]. Additionally, Liu et al, after freezing and vacuum drying a fresh amniotic membrane, effectively removed most of the cell components in the amniotic membrane to retain bioactive molecules, and built a growth factor release system that conformed to the tendon healing cycle.…”

Section: Functional Electrospinning Products Of 3d Structures For Ten...mentioning

confidence: 99%

Biodegradable Polymer Electrospinning for Tendon Repairment

et al. 2023

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With the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain limitations. Biodegradable polymer electrospinning technology with good biocompatibility and degradability can effectively repair tendons, and its mechanical properties can be achieved by adjusting the fiber diameter and fiber spacing. Here, this review first briefly introduces the structure and function of the tendon and the repair process after injury. Then, different kinds of biodegradable natural polymers for tendon repair are summarized. Then, the advantages and disadvantages of three-dimensional (3D) electrospun products in tendon repair and regeneration are summarized, as well as the optimization of electrospun fiber scaffolds with different bioactive materials and the latest application in tendon regeneration engineering. Bioactive molecules can optimize the structure of these products and improve their repair performance. Importantly, we discuss the application of the 3D electrospinning scaffold’s superior structure in different stages of tendon repair. Meanwhile, the combination of other advanced technologies has greater potential in tendon repair. Finally, the relevant patents of biodegradable electrospun scaffolds for repairing damaged tendons, as well as their clinical applications, problems in current development, and future directions are summarized. In general, the use of biodegradable electrospun fibers for tendon repair is a promising and exciting research field, but further research is needed to fully understand its potential and optimize its application in tissue engineering.

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Section: Functional Electrospinning Products Of 3d Structures For Ten...mentioning

confidence: 99%

Biodegradable Polymer Electrospinning for Tendon Repairment

et al. 2023

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“…The effects of multiscale structure and polymer type on cell function (after implantation of rBMSCs) and AT mechanical properties were investigated ( Sankar et al, 2021 ; Yin et al, 2022 ). Zhao et al (2019) added an exogenous BFGF-loaded fibrin gel to a porous network of knitted PLGA scaffolds.…”

Section: Nanofiber-based Scaffoldsmentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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“…In addition to achieve the sustained release function as an encapsulation system, PEM and collagen were also used to mimic Frontiers in Bioengineering and Biotechnology frontiersin.org bone tissue ECM to promote osteogenic differentiation via modifying different surface properties which in turn stimulating numerous interfacial interactions with the cells adsorbed to the coated surfaces (Brito Barrera et al, 2020;Sankar et al, 2021). Collagen is an indispensable matrix protein that stimulates various signaling pathways such as cell adhesion, mobility, wound healing, proliferation, and an important process to complete bone regeneration, named ECM remodeling (Zhang et al, 2018).…”

Section: In Vitro Cytotoxicitymentioning

confidence: 99%

Encapsulated vaterite-calcite CaCO3 particles loaded with Mg2+ and Cu2+ ions with sustained release promoting osteogenesis and angiogenesis

Fan

Körte

Rudt

et al. 2022

Front. Bioeng. Biotechnol.

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Bioactive cations, including calcium, copper and magnesium, have shown the potential to become the alternative to protein growth factor-based therapeutics for bone healing. Ion substitutions are less costly, more stable, and more effective at low concentrations. Although they have been shown to be effective in providing bone grafts with more biological functions, the precise control of ion release kinetics is still a challenge. Moreover, the synergistic effect of three or more metal ions on bone regeneration has rarely been studied. In this study, vaterite-calcite CaCO3 particles were loaded with copper (Cu2+) and magnesium (Mg2+). The polyelectrolyte multilayer (PEM) was deposited on CaCuMg-CO3 particles via layer-by-layer technique to further improve the stability and biocompatibility of the particles and to enable controlled release of multiple metal ions. The PEM coated microcapsules were successfully combined with collagen at the outmost layer, providing a further stimulating microenvironment for bone regeneration. The in vitro release studies showed remarkably stable release of Cu2+ in 2 months without initial burst release. Mg2+ was released in relatively low concentration in the first 7 days. Cell culture studies showed that CaCuMg-PEM-Col microcapsules stimulated cell proliferation, extracellular maturation and mineralization more effectively than blank control and other microcapsules without collagen adsorption (Ca-PEM, CaCu-PEM, CaMg-PEM, CaCuMg-PEM). In addition, the CaCuMg-PEM-Col microcapsules showed positive effects on osteogenesis and angiogenesis in gene expression studies. The results indicate that such a functional and controllable delivery system of multiple bioactive ions might be a safer, simpler and more efficient alternative of protein growth factor-based therapeutics for bone regeneration. It also provides an effective method for functionalizing bone grafts for bone tissue engineering.

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Combinatorial effect of plasma treatment, fiber alignment and fiber scale of poly (ε-caprolactone)/collagen multiscale fibers in inducing tenogenesis in non-tenogenic media

Cited by 19 publications

References 78 publications

Biodegradable Polymer Electrospinning for Tendon Repairment

Biodegradable Polymer Electrospinning for Tendon Repairment

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Encapsulated vaterite-calcite CaCO3 particles loaded with Mg2+ and Cu2+ ions with sustained release promoting osteogenesis and angiogenesis

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