Combination Therapy for Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia

Gandhi, Tejal; Malani, Preeti N.

doi:10.1001/jama.2019.21472

Cited by 12 publications

(5 citation statements)

References 16 publications

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“…Pathogens such as vancomycin-resistant Enterococcus faecium and multidrug-resistant Staphylococcus aureus , which are on the CDC’s list of serious threats, could jeopardize health care systems because there are limited defenses against them , and there is a potential of transferring chemical resistance to more dangerous pathogens . Combinatorial treatments that target multiple bacterial pathways or enhance drug activity are currently used, for example the coadministration of amoxicillin and clavulanic acid to treat β-lactamase-producing S. aureus and, despite some controversy, combinations of vancomycin with β-lactams or daptomycin as a last resort therapy. Finding compounds that act in synergistic ways might improve our chances of fighting AR and, in turn, our ability to combat infectious diseases.…”

mentioning

confidence: 99%

Antibacterial Drimane Sesquiterpenes from Aspergillus ustus

Neuhaus

Loesgen

2020

J. Nat. Prod.

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Bioactivity-guided isolation of Aspergillus ustus led to the discovery of five new drimane sesquiterpenes, named ustusal A, ustusolate F and G, and ustusoic acid A and B, 1–5 respectively. Structural elucidation of these fungal terpenes relied on 1D and 2D NMR techniques, high-resolution mass spectrometry, and chiroptical properties. Their relative configurations were determined by NMR methods, while the absolute configurations were established using comparative analyses of computed and experimental NMR chemical shifts and ECD spectra. The sesquiterpenes exhibited weak activity against the clinically relevant pathogens vancomycin-resistant Enterococcus faecium and multidrug-resistant Staphylococcus aureus; however, the activity of 5 was drastically enhanced when equal amounts of stromemycin (6), a known metabolite coisolated from the same fraction from A. ustus, was added.

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confidence: 99%

Antibacterial Drimane Sesquiterpenes from Aspergillus ustus

Neuhaus

Loesgen

2020

J. Nat. Prod.

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“…In the early stage, it was mainly treated in combination with other antibiotics, such as streptomycin and penicillin. The combination of antibiotics has a synergistic effect, which not only has better efficacy than a single drug, but also can inhibit the drug resistance selection of a single drug ( 45 , 46 ). With the development of multi-drug resistant bacteria, antibiotic substitutes ( 47 ) such as phage therapy ( 48 – 50 ), nanomaterials ( 51 – 54 ), bacteriocins ( 55 ), antibodies, and probiotics ( 56 ) have been attracted more attention.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistant bacteria: A bibliometric review of literature

Sun

Zhang

Dong

et al. 2022

Front. Public Health

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Antibiotic-resistant bacteria (ARB) are a serious threat to the health of people and the ecological environment. With this problem becoming more and more serious, more countries made research on the ARB, and the research number has been sharply increased particularly over the past decade. Therefore, it is quite necessary to globally retrace relevant researches on the ARB published from 2010 to 2020. This will help researchers to understand the current research situation, research trends and research hotspots in this field. This paper uses bibliometrics to examine publications in the field of ARB from 2010 to 2020 that were retrieved from the Web of Science (WOS). Our study performed a statistical analysis of the countries, institutions, journals, authors, research areas, author keywords, Essential Science Indicators (ESI) highly cited papers, and ESI hotspots papers to provide an overview of the ARB field as well as research trends, research hotspots, and future research directions in the field. The results showed that the number of related studies is increasing year by year; the USA is most published in the field of ARB; China is the most active in this field in the recent years; the Chinese Acad Sci published the most articles; Sci. Total Environ. published the greatest number of articles; CM Manaia has the most contributions; Environmental Sciences and Ecology is the most popular research area; and “antibiotic resistance,” “antibiotics,” and “antibiotic resistance genes” were the most frequently occurring author keywords. A citation analysis showed that aquatic environment-related antibiotic resistance is a key research area in this field, while antimicrobial nanomaterial-related research is a recent popular topic.

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“…At present, various commercially available antimicrobial drugs exhibit some prominent defects, including nonspecific targeting and low concentrations in the lesion, which leads to low efficiency, high toxicity, various side effects 15 and multidrug resistance. 16 , 17 In the era of precision medicine, targeted drug design has been intensively developed, 18 and high efficiency and sufficient safety have become the main goals for targeted drug design. 19 Therefore, it is important to develop a targeted antimicrobial drug delivery system as a novel strategy for the prevention and treatment of sepsis.…”

Section: Introductionmentioning

confidence: 99%

Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach

Zhang

Luo

et al. 2022

Sig Transduct Target Ther

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Effectively killing pathogenic bacteria is key for the treatment of sepsis. Although various anti-infective drugs have been used for the treatment of sepsis, the therapeutic effect is largely limited by the lack of a specific bacterium-targeting delivery system. This study aimed to develop antibacterial peptides that specifically target pathogenic bacteria for the treatment of sepsis. The lethal bacterial strain Escherichia coli MSI001 was isolated from mice of a cecal ligation and puncture (CLP) model and was used as a target to screen bacterial binding heptapeptides through an integrative bioinformatics approach based on phage display technology and high-throughput sequencing (HTS). Heptapeptides binding to E. coli MSI001 with high affinity were acquired after normalization by the heptapeptide frequency of the library. A representative heptapeptide VTKLGSL (VTK) was selected for fusion with the antibacterial peptide LL-37 to construct the specific-targeting antibacterial peptide VTK-LL37. We found that, in comparison with LL37, VTK-LL37 showed prominent bacteriostatic activity and an inhibitive effect on biofilm formation in vitro. In vivo experiments demonstrated that VTK-LL37 significantly inhibited bacterial growth, reduced HMGB1 expression, alleviated lesions of vital organs and improved the survival of mice subjected to CLP modeling. Furthermore, membrane DEGP and DEGQ were identified as VTK-binding proteins by proteomic methods. This study provides a novel strategy for targeted pathogen killing, which is helpful for the treatment of sepsis in the era of precise medicine.

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Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia

Cited by 12 publications

References 16 publications

Antibacterial Drimane Sesquiterpenes from Aspergillus ustus

Antibacterial Drimane Sesquiterpenes from Aspergillus ustus

Antibiotic resistant bacteria: A bibliometric review of literature

Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach

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