Antibiotic resistant bacteria: A bibliometric review of literature

Abstract

Antibiotic-resistant bacteria (ARB) are a serious threat to the health of people and the ecological environment. With this problem becoming more and more serious, more countries made research on the ARB, and the research number has been sharply increased particularly over the past decade. Therefore, it is quite necessary to globally retrace relevant researches on the ARB published from 2010 to 2020. This will help researchers to understand the current research situation, research trends and research hotspots in this field. This paper uses bibliometrics to examine publications in the field of ARB from 2010 to 2020 that were retrieved from the Web of Science (WOS). Our study performed a statistical analysis of the countries, institutions, journals, authors, research areas, author keywords, Essential Science Indicators (ESI) highly cited papers, and ESI hotspots papers to provide an overview of the ARB field as well as research trends, research hotspots, and future research directions in the field. The results showed that the number of related studies is increasing year by year; the USA is most published in the field of ARB; China is the most active in this field in the recent years; the Chinese Acad Sci published the most articles; Sci. Total Environ. published the greatest number of articles; CM Manaia has the most contributions; Environmental Sciences and Ecology is the most popular research area; and “antibiotic resistance,” “antibiotics,” and “antibiotic resistance genes” were the most frequently occurring author keywords. A citation analysis showed that aquatic environment-related antibiotic resistance is a key research area in this field, while antimicrobial nanomaterial-related research is a recent popular topic.

Potent Inhibition of E. coli DXP Synthase by a gem-Diaryl Bisubstrate Analog

“…This study focused on the bacterial central metabolic enzyme DXPS, a promising antibacterial target. Our previous work discovered the DXPS inhibitor D-PheTrAP (1), which is a submicromolar, time-dependent bisubstrate analog inhibitor of DXPS bearing an acetylphosphonate mimic of the donor substrate pyruvate linked to a carboxy mimic of the acceptor substrate D-GAP. 24 Carboxyl and benzyl substituents were both found to contribute to the potency of 1, with the carboxyl moiety making key contacts to arginine residues (EcR420 and R478) in the GAP binding pocket.…”

“…NMR spectra were recorded using a JEOL or Bruker 500 MHz NMR spectrometer. 1 H NMR chemical shifts are reported in δ (ppm) relative to chloroformd at 7.27 ppm, methanol-d 4 at 3.31 ppm, dimethyl sulfoxide (DMSO)-d 6 at 2.50 ppm, or deuterium oxide at 4.79 ppm. 31 P NMR chemical shifts are reported relative to an external standard of triphenylphosphine oxide (TPPO) in benzene-d 6 set to 0.0 ppm.…”

“…Antimicrobial resistance predates the discovery of antibiotics and is an unavoidable threat in the treatment of infectious diseases. To combat resistance, new antibacterial strategies are needed that are selective for pathogens and avoid toxicity to the host microbiome, which can negatively impact human health. − Agents that target central metabolic processes are increasingly sought − and have the potential to exert narrow-spectrum activities. ,− However, this target space is relatively underexploited owing to the complexities in developing central metabolism targets and the perceived difficulties in selectively targeting bacterial metabolism over host metabolism. ,,, Essential to bacterial central metabolism and absent in humans, 1-deoxy- d -xylulose 5-phosphate synthase (DXPS) emerged as a promising antibacterial target with the potential to offer opportunities for developing narrow spectrum approaches. ,− …”

One-step antibacterial modification of polypropylene non-woven fabricsviaoxidation using photo-activated chlorine dioxide radicals

“…6 Although many antibiotics and antibacterial drugs have been developed, 7,8 the emerging antimicrobial resistance (AMR) of bacteria has made the control and treatment of bacterial infections difficult. 9,10 For example, methicillin-resistant Staphylococcus aureus (MRSA) shows resistance against most b-lactam antibiotics, and the spread of MRSA in hospitals is an urgent problem. 11,12 Hence, an antibacterial strategy that is independent of antibiotics is a desirable solution.…”

One-step antibacterial modification of polypropylene nonwoven fabrics via oxidation using photo-activated chlorine dioxide radicals

“…2 While many antibiotics and antibacterial drugs have been developed, 3,4 emerging antimicrobial resistance (AMR) of bacteria has made the control and treatment of bacterial infections difficult. 5,6 For example, methicillin-resistant Staphylococcus aureus (MRSA) shows resistance against most β-lactam antibiotics, and the spread of MRSA in hospitals is an urgent problem. 7,8 Hence, an antibacterial strategy independent of antibiotics is a desirable solution.…”