Combination of Ginger and Sappan Wood Extract Effect on In vivo Antithrombotic Activity Test

Saputri, Fadlina Chany; Nabila, Nida; Mun’im, Abdul

doi:10.5530/jyp.2017.1s.12

Cited by 10 publications

(23 citation statements)

References 13 publications

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“…An in vivo assay similar with the previous study 16 was performed to revealed the effect of both extracts on bleeding time and survival rate. Each of the crude extract with three doses were suspended in 0.5% CMC-Na to obtain the suspension of plant extract.…”

Section: Methodsmentioning

confidence: 99%

“…An established method from Saputri et al performed to provide a pulmonary thromboembolism (PE) model. 16 After 24 hours from the last administration of the plant extract or ASA or 0.5% CMC-Na, the mixture solution of collagen and epinephrine (CE) was injected through the tail vein to induce PE. While the normal group was given an injection of normal saline.…”

Section: Pulmonary Thromboembolism Modelmentioning

confidence: 99%

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Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice

Sakti¹,

Nityasa²,

Saputri³

2020

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Background: Previous studies on virtual screening on P2Y 12 receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. Objective: In this study, we investigated the effect of Uncaria gambir and Uncaria sclerophylla extract on survival rate and bleeding time as antithrombotic in vivo. Methods: Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). U. gambir and U. sclerophylla were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. Results: U. gambir and U. sclerophylla able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group. Conclussion: Both of U. gambir and U. sclerophylla prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.

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Section: Methodsmentioning

confidence: 99%

Section: Pulmonary Thromboembolism Modelmentioning

confidence: 99%

Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice

Sakti¹,

Nityasa²,

Saputri³

2020

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“…The treatment of bleeding time was determined according to protocols described by Saputri et al (2017) with the following modifications. Mice were divided into the treatment groups shown in Table 1 and acclimatized for 1 week.…”

Section: Bleeding Time Testmentioning

confidence: 99%

“…Experimental treatment doses were given to mice through oral administration for 7 days. The dose of aspirin applied was 80 mg/day [12][13][14]. Experimental TIE doses were 14, 28, and 56 mg/20 g mice.…”

Section: Bleeding Time Testmentioning

confidence: 99%

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Antithrombotic Activity of Tamarindus Indica L. In Mice

2018

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Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo).Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithromboticactivity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-inducedthromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group.Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected micefrom thromboembolic death, significantly increasing survival rates in a dose-dependent manner.Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.

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