Antithrombotic Activity of Tamarindus Indica L. In Mice

Saputri, Fadlina Chany; Avatara, Chavella; Rachmawati, Dian

doi:10.22159/ijap.2018.v10s1.08

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…26 We have successfully determined antithrombotic effect from various natural product using this CE-induced mice model at the previous studies. [27][28][29][30] There are three classes of antithrombotic agents, including: agents that inhibit aggregation of platelet, inhibit fibrin strands formation (known as anticoagulant), and agent that dissolve exiting clots (known as fibrinolytic). Both of antiplatelet and anticoagulant work through preventing thrombogenesis, but not affect the clots that already formed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice

Sakti¹,

Nityasa²,

Saputri³

2020

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Background: Previous studies on virtual screening on P2Y 12 receptor of Adenosine Diphosphate (ADP) have showed that Roxburghine B, the compound which is found in Uncaria species, can inhibit the receptor function. Objective: In this study, we investigated the effect of Uncaria gambir and Uncaria sclerophylla extract on survival rate and bleeding time as antithrombotic in vivo. Methods: Animal subjects (ddY strain mice) were divided to two different experimental group (survival rate and bleeding time). U. gambir and U. sclerophylla were given to the mice orally in three different dose (5 mg, 10 mg, 20 mg/20 g BW and 2.5 mg, 5 mg, 10 mg/20 g BW, respectively) for seven days. Results: U. gambir and U. sclerophylla able to prolong bleeding time from test subjects equivalent to ASA as standard. The results show the increasing number of survived animals in the treated group compared to the negative control group. Conclussion: Both of U. gambir and U. sclerophylla prevent pulmonary thromboembolism on mice subjects represent by the increased of survival rate. Antithrombotic effects that were observed suggested was provide by their antiplatelet activity.

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Section: Discussionmentioning

confidence: 99%

Effect of Uncaria gambir and Uncaria sclerophylla on Pulmonary- Thromboembolism Mice

Sakti¹,

Nityasa²,

Saputri³

2020

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“…Tamarind is a type of tropical fruit tree under the subfamily of Caesalpinioideae from the family Leguminosae (Fabaceae) which has many benefits for human life as traditional medicine (Bhadoriya et al, 2011). In several countries on the African and Asian continents, it was reported that the fruit, leaves, and bark of the tamarind flowers are used in the pharmaceutical industry and traditional medicine as a laxative, antithrombotic, wound treatment, diarrhea, abdominal pain, dysentery, constipation, snake bites, colds, inflammation, helminth infection, and fever so that it can play a role as antimicrobial, antidiabetic, anti-inflammatory and effects on satiety control, potential in the treatment or prevention of obesity and other chronic diseases (Havinga et al, 2010;Krishna, Anitha, & Ezhilarasan, 2020;Kuru, 2014;Menezes, Trevisan, Barbalho, & Guiguer, 2016;Rizkiany, Amelia, Bimantara, Sagami, & Basyuni, 2021;Saputri, Avatara, & Rachmawati, 2018). In particular, the flower's concentration of extracts and seed oil can be used as antioxidants (Souza et al, 2020;Sutrisno, Retnosari, Marfu'ah, & Fajaroh, 2019).…”

Section: Introductionmentioning

confidence: 99%

Tamarind (Tamarindus indica L.): Source of Ideas Behind the Semarang Batik Motifs to Strengthen Local Cultural Identity

et al. 2022

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Tamarind (Tamarindus indica L.), a type of tropical plant that grows in Indonesia has various benefits and has been widely studied by various disciplines. The study of Tamarind as a source of ideas for art creation, on the other hand, has not been widely carried out. The aims of this study are: (1) To explain the process of creating Semarang batik motifs using the idea of Tamarind through the stylization of forms; (2) to analyze the shape of the Tamarind batik motif to strengthen the identity of Semarang’s local culture. This study uses a qualitative approach with phenomenological methods to examine phenomena related to the creation process and the uniqueness of locality-based batik motifs on batik artisans in Semarang City. The data collection techniques used were observation, in-depth interviews, and document studies. The data that has been collected was analyzed interactively through data reduction, presentation, and conclusions with the scope of analysis in intra-aesthetic and extra-aesthetic studies. The results showed that: (1) Tamarind is a typical plant that is closely related to the toponym of the city of Semarang so it becomes a source of ideas for the creation of locality-based batik motifs through the stylization technique by Semarang batik artisans; (2) Visualization of the shape of the Tamarind batik motif that has been produced shows the diversity and uniqueness of the form as an aesthetic expression of the batik artisan in responding to the beauty of the natural and socio-cultural environment in Semarang City according to the level of knowledge and aesthetic experience. This research contributes to the batik artisan in exploring the diversity of local plant species as a source of ideas for creating environmentally-based batik motifs to strengthen the value of local cultural identity.

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