Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism

Tavares, Caio P.; Sousa, Isabella Chaves; Gomes, Matheus N; Miró, Victoria; Virkel, G.; Lifschitz, Adrián Luis; Costa-Júnior, Lívio Martins

doi:10.1016/j.ttbdis.2021.101874

Cited by 14 publications

(7 citation statements)

References 73 publications

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“…The search for alternatives to control R. microplus is one of the biggest challenges for cattle production as illustrated by several reports about emergence of multi-resis ta nt tick populations (Tavares et al, 2022). This study presents in silico and in vitro evidence of inhibition of R. microplus GST by the purified plant alkaloid anonaine, which improved the cypermethrin in vitro larvicidal effect.…”

Section: Discussionmentioning

confidence: 83%

Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Bezerra¹,

Tavares²,

Rocha³

et al. 2022

Experimental Parasitology

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Section: Discussionmentioning

confidence: 83%

Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Bezerra¹,

Tavares²,

Rocha³

et al. 2022

Experimental Parasitology

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“…Previous studies have shown that EOs can inhibit detoxifying enzymes and improve the overall toxicity of synthetic insecticides by increasing their bioavailability and interaction with the target site in the insect 44 . Notably, some studies have reported the use of EOs or major compounds as synergists of CP against arthropod pests 20–25 . However, to the best of our knowledge, this is the first report on the formulation of a single NE that combines EO and CP in the same formulation using Tween 80 and ultrasound.…”

Section: Resultsmentioning

confidence: 93%

“…Moreover, it was reported that monoterpenes such as linalool and 1,8‐cineole improved CP effects on Spodoptera litura Fabricius (Lepidoptera, Noctuidae) 23 . Additionally, thymol combined with CP increased acaricidal efficacy against Rhipicephalus microplus Canestrii (Ixodida, Ixodidae) by four‐fold 24 . Finally, Jesser et al 20,25 .…”

Section: Introductionmentioning

confidence: 97%

“…23 Additionally, thymol combined with CP increased acaricidal efficacy against Rhipicephalus microplus Canestrii (Ixodida, Ixodidae) by fourfold. 24 Finally, Jesser et al 20,25 demonstrated that NEs loaded with geranium, peppermint or palmarosa EOs enhanced the insecticidal activity of ⊎-cypermethrin (⊎-CP) by 3.78-12.25 times on Plodia interpunctella (Lepidoptera, Pyralidae) and 1.67-2.84 times on Cx. P. pipiens.…”

Section: Introductionmentioning

confidence: 99%

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Development and characterization of nanoemulsions loaded with essential oil and β‐cypermethrin and their bioefficacy on insect pest of economic and medical importance

Jesser

Yeguerman

Urrutia

et al. 2023

Pest Management Science

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BackgroundThe development of novel and ecofriendly tools plays an important role in insect pest management. Nanoemulsions (NEs) based on essential oils (EOs) offer a safer alternative for human health and the environment. This study aimed to elaborate and evaluate the toxicological effects of NEs containing peppermint or palmarosa EOs combined with β‐cypermethrin (β‐CP) using ultrasound technique.ResultsThe optimized ratio of active ingredients to surfactant was 1:2. The NEs containing peppermint EO combined with β‐CP (NEs peppermint/β‐CP) were polydisperse with two peaks at 12.77 nm (33.4% intensity) and 299.1 nm (66.6% intensity). However, the NEs containing palmarosa EO combined with β‐CP (NEs palmarosa/β‐CP) were monodisperse with a size of 104.5 nm. Both NEs were transparent and stable for 2 months. The insecticidal effect of NEs was evaluated against Tribolium castaneum and Sitophilus oryzae adults, as well as Culex pipiens pipiens larvae. On all these insects, NEs peppermint/β‐CP enhanced pyrethroid bioactivity from 4.22‐ to 16‐folds while NEs palmarosa/β‐CP, from 3.90‐ to 10.6‐folds. Moreover, both NEs maintained high insecticidal activities against all insects for 2 months, although a slight increase of the particle size was detected.ConclusionThe NEs elaborated in this work can be considered as highly promising formulations for the development of new insecticides. © 2023 Society of Chemical Industry.

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“…Two monoterpenes (carvacrol and thymol) were used alone or in combination with cypermethrin to control R. microplus. It was observed that thymol enhances cypermethrin toxicity ( Tavares et al., 2022b ), and that both monoterpenes increased the activity of antioxidant and detoxifying enzymes (glutathione-S-transferase, catalase, superoxide dismutase, and glutathione peroxidase) in the R. microplus ticks ( Tavares et al., 2022a ). The combination of essential oils from Cinnamomum zeylanicum , Cuminum cyminum , and Pimenta dioica in emulsion preparations showed a synergic effect against R. microplus ( Lazcano Díaz et al., 2019 ).…”

Section: Mitigation Of Acaricide Resistance and Alternative Control M...mentioning

confidence: 99%

Acaricides Resistance in Ticks: Selection, Diagnosis, Mechanisms, and Mitigation

Obaid

Islam

Alouffi

et al. 2022

Front. Cell. Infect. Microbiol.

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Ticks are blood-feeding ecto-parasites that have a cosmopolitan distribution in tropical and subtropical regions of the world. Ticks cause economic losses in the form of reduced blood, meat and dairy products, as well as pathogen transmission. Different acaricides such as organochlorines, organophosphates, formamidines (e.g. amitraz), synthetic pyrethroids, macrocyclic lactones, fipronil, and fluazuron are currently used sequentially or simultaneously to control tick infestations. Most acaricide treatments now face increasingly high chances of failure, due to the resistance selection in different tick populations against these drugs. Acaricide resistance in ticks can be developed in different ways, including amino acid substitutions that result in morphological changes in the acaricide target, metabolic detoxification, and reduced acaricide entry through the outer layer of the tick body. The current literature brings a plethora of information regarding the use of different acaricides for tick control, resistance selection, analysis of mutations in target sites, and resistance mitigation. Alternatives such as synergistic use of different acaricides, plant-derived phytochemicals, fungi as biological control agents, and anti-tick vaccines have been recommended to avoid and mitigate acaricide resistance. The purpose of this review was to summarize and discuss different acaricides applied for tick control, their mechanisms of action and resistance selection, genetic polymorphisms in their target molecules, as well as the approaches used for diagnosis and mitigation of acaricide resistance, specifically in Rhipicephalus microplus ticks.

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Combination of cypermethrin and thymol for control of Rhipicephalus microplus: Efficacy evaluation and description of an action mechanism

Cited by 14 publications

References 73 publications

Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Development and characterization of nanoemulsions loaded with essential oil and β‐cypermethrin and their bioefficacy on insect pest of economic and medical importance

Acaricides Resistance in Ticks: Selection, Diagnosis, Mechanisms, and Mitigation

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