Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Bezerra, Wallyson André dos Santos; Tavares, Caio P.; Rocha, Cláudia Quintino da; Vaz, Itabajara da Silva; Michels, Paul A.M.; Costa, Lívio Martins; Soares, Alexandra Martins dos Santos

doi:10.1016/j.exppara.2022.108398

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Ellagic acid and quercetin have been reported to have antibacterial, antiviral, antimalarial, antiparasitic, antioxidant, and anti-inflammatory properties in previous studies [56][57][58][59]. The GST from R. microplus has also been reported to be inhibited by several other compounds such as anonaine from Annona crassiflora [60], norapoatropine, and 7-Hydroxyhyoscyamine from Datura innoxia [48].…”

Section: Discussionmentioning

confidence: 97%

In Silico Exploration and Experimental Validation of Camellia sinensis Extract against Rhipicephalus microplus and Sarcoptes scabiei: An Integrated Approach

Hakami,

Malak,

Khan

et al. 2023

Life

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Sarcoptes scabiei is an ectoparasite of humans and animals that causes scabies. The Rhipicephalus (Boophilus) microplus is a blood-sucking ectoparasite that transmits various pathogens. These two parasites have caused great losses to a country’s dairy and agriculture sectors. The aim of this study was to determine the in vitro and in silico efficacy of Camellia sinensis plant extracts. Different concentrations of C. sinensis ethanolic plant extracts were prepared using the maceration method and were used against mites and ticks (in adult immersion test AIT and larval packet test LPT) to evaluate their in vitro acaricidal activity. Additionally, in silico molecular docking was performed to investigate the inhibitory interactions between the phytochemicals of the plant and S. scabiei and R. microplus glutathione transferase proteins (SsGST and RmGST). This study observed that the plant extract showed high efficacy in vitro against mites and different tick stages in adult immersion and larval packet tests. Additionally, the in silico study revealed a strong binding interaction between ellagic acid and SsGST protein, with a binding energy of −7.3 kcal/mol, with respect to permethrin (−6.7 kcal/mol), whereas quercetin and RmGST resulted in a docking score of −8.6 kcal/mol compared to deltamethrin (−8.2 kcal/mol). Overall, this study explored the potential of C. sinensis as a natural alternative for controlling tick and mite infestations and provided insights into the inhibitory mechanisms of its phytochemicals.

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Section: Discussionmentioning

confidence: 97%

In Silico Exploration and Experimental Validation of Camellia sinensis Extract against Rhipicephalus microplus and Sarcoptes scabiei: An Integrated Approach

Hakami,

Malak,

Khan

et al. 2023

Life

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Putative target sites in synganglion for novel ixodid tick control strategies

Waldman

Klafke

Tirloni

et al. 2023

Ticks and Tick-borne Diseases

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Evaluation of Ethanol Extract of Magnolia alejandrae (Magnoliales: Magnoliaceae) against Tetranychus merganser (Acari: Tetranychidae)

Olazaran-Santibañez,

Heinz-Castro,

Rivera

et al. 2024

Journal of Entomological Science

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Tetranychus merganser Boudreaux (Acari: Tetranychidae) is one of the most economically important mite pests of papaya (Carica papaya L.) crops grown along the Gulf of México. Control of this mite depends mainly on chemical insecticides. This research aims to evaluate the effects of different concentrations (0.1, 0.5, 1, 5, 10, and 15% [v/v]) of the ethanolic extract of Magnolia alejandrae García-Morales and Iamonico (Magnoliaceae) leaves on T. merganser adult females, as well as to obtain information about the chemical composition of the extract. The ethanolic extracts contained some phytochemicals such as phenolic compounds, alkaloids, glycosides, ketones, terpenes, and quinones. Females treated with 0.1 and 15% (v/v) of the extract showed mortality of 0.0% and 33.3% at 72 h, respectively, as compared to the control treatment. The mites treated with 15% (v/v) of the extract decreased their oviposition rate (5.90, 5.35, and 4.77 eggs/female), compared to the control treatment (13.27, 13.95, and 14.39 eggs/female) at 24, 48, and 72 h, respectively, which led to a reduction in the growth rate. The feeding damage caused by T. merganser was reduced at high concentrations. Magnolia alejandrae leaf ethanolic extract has potential for development as a control agent for T. merganser.

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Anonaine from Annona crassiflora inhibits glutathione S-transferase and improves cypermethrin activity on Rhipicephalus (Boophilus) microplus (Canestrini, 1887)

Cited by 3 publications

References 57 publications

In Silico Exploration and Experimental Validation of Camellia sinensis Extract against Rhipicephalus microplus and Sarcoptes scabiei: An Integrated Approach

In Silico Exploration and Experimental Validation of Camellia sinensis Extract against Rhipicephalus microplus and Sarcoptes scabiei: An Integrated Approach

Putative target sites in synganglion for novel ixodid tick control strategies

Evaluation of Ethanol Extract of Magnolia alejandrae (Magnoliales: Magnoliaceae) against Tetranychus merganser (Acari: Tetranychidae)

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