Combination of astaxanthin and fish oil supplementation alters antioxidant enzyme profile of dental pulp tissue

Leite, Mariana Ferreira; Lima, Amanda Martins de; Otton, Rosemari

doi:10.1111/j.1365-2591.2012.02080.x

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…Highly fatty diets constitute a known environmental factor that may alter the susceptibility to oral [8,31] and systemic [32,33] diseases. In this study, we investigated the progression of AP in rats submitted to a high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

High-fat diet effect on periapical lesions and hepatic enzymatic antioxidant in rats

et al. 2021

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Section: Discussionmentioning

confidence: 99%

High-fat diet effect on periapical lesions and hepatic enzymatic antioxidant in rats

et al. 2021

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“…As in any other wound healing, healing of exposed dental pulp passes through hemostasis, inflammation, cell proliferation, angiogenesis, and eventually tissue remodeling (21,22). Conditions associated with oxidative stress such as inflammation, hypoxia, or the effects of systemic diseases often occur in dental pulp (23). Carious lesion as well as pulp exposure during caries excavation often led to reversible pulp inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…During inflammation, immune cells including macrophages and neutrophils produce cytokines as well as ROS in order to destroy pathogens (24,25). In order to cope with ROS production, the cells of the organism possess anti-oxidant systems that include enzymes such as catalase, superoxide dismutase, hydrogen peroxidase and the system of glutathione peroxidase and reductase, among others (17,23,25,26). However, inability of anti-oxidant systems to cope with overproduction of ROS can led to disorders of local oxidative status that can negatively affect surrounding healthy cells causing oxidative stress and leading to irreversible pulp disorders.…”

Section: Discussionmentioning

confidence: 99%

Influence of Direct Pulp Capping with Calcium Hydroxide and Mineral Trioxide Aggregate on Systemic Oxidative Stress in Rats

Živanović

Papic

Vuletic

et al. 2022

Experimental and Applied Biomedical Research (EABR)

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Direct pulp capping is a procedure where materials are placed on exposed vital pulp tissue in order to stimulate reparative dentinogenesis and preserve pulp vitality. Carious pulp exposure and direct pulp capping are usually accompanied by pulp inflammation which can affect pro- and anti-oxidative systems locally or systemically. Therefore, this study aimed to investigate the potential influence of direct capping of inflamed rat dental pulp with calcium hydroxide (CH) and mineral trioxide aggregate (MTA) on parameters of systemic oxidative status. Dental pulps of the first maxillary molars of Albino rats (n=32) were exposed and capped with either CH (n=8), MTA (n=8) or were left untreated (n=8). Animals with healthy pulp were used as a healthy control (n=8). After four weeks, animals were euthanized and blood samples were collected for biochemical analysis of parameters of systemic oxidative stress by spectrophotometric method. Untreated control had the significantly higher (p <0.05) values of pro-oxidative parameters and lower (p <0.05) values of anti-oxidative parameters (superoxide dismutase and reduced glutathione) compared to healthy control. CH and MTA groups showed reduced values of pro-oxidative parameters compared to untreated control and values of anti-oxidative parameters comparable to healthy control. Pulp exposure led to disbalance in systemic oxidative parameters while direct pulp capping with calcium hydroxide and mineral trioxide aggregate restored the levels of systemic oxidative parameters to that of animals with healthy dental pulp. These results indicate the importance of direct pulp capping and the potential influence of untreated inflamed pulp on systemic health.

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“…Newer strategies such as incorporation of phytochemicals with FO or n-3 PUFA have yielded better protective effects in preventing diseases associated with oxidative stress [21] . In this regard, we have found enhanced neuroprotection among rats when FO was supplemented with Ferulic acid or quercetin against NPA induced neurotoxicity [22,23] .…”

Section: International Journal Of Neurology Researchmentioning

confidence: 99%

Neuroprotective Efficacy of A Combination of Fish Oil and Bacopa Monnieri Against 3-Nitropropionic Acid Induced Oxidative Stress in Rats

Kollareth

Muralidhara

2017

International Journal of Neurology Research

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NPA (10 mg/kg bw, 14d) were supplemented with FO (2 mL/kg bw), BM (100 mg/kg bw) or combination (FO+BM) for 14 days. RESULTS: Higher degree of protection was discernible among FO+BM rats against NPA induced behavioral alterations. Further, NPA administration resulted in significantly elevated oxidative markers in brain regions (striatum-St, cerebellum-Cb) while robust protection was evident among rats supplemented with FO+BM. Depleted GSH levels in St were restored among all the supplemented groups. The combination also predominantly normalized the activity of antioxidant enzymes in brain regions. Further, significantly depleted dopamine levels in St were partially restored only among FO+BM rats. However, the combination did not offer protection against NPA induced mitochondrial dysfunction. CONCLUSION: The present data clearly suggests that it is possible to enhance the degree of neuroprotection by a combination of FO with phytochemicals (such as BM) and thus provides an improved strategy for the treatment/ management of oxidative stress mediated neurodegenerative conditions.

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Combination of astaxanthin and fish oil supplementation alters antioxidant enzyme profile of dental pulp tissue

Abstract: The preventive administration of ASTA and FO changed the enzymatic antioxidant system of dental pulp tissue, possibly by controlling oxidative stress.

Cited by 8 publications

References 36 publications

High-fat diet effect on periapical lesions and hepatic enzymatic antioxidant in rats

High-fat diet effect on periapical lesions and hepatic enzymatic antioxidant in rats

Influence of Direct Pulp Capping with Calcium Hydroxide and Mineral Trioxide Aggregate on Systemic Oxidative Stress in Rats

Neuroprotective Efficacy of A Combination of Fish Oil and Bacopa Monnieri Against 3-Nitropropionic Acid Induced Oxidative Stress in Rats

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