Combination Effect of Antituberculosis Drugs and Ethanolic Extract of Selected Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis Isolates

Fauziyah, Prabasiwi Nur; Sukandar, Elin Yulinah; Ayuningtyas, Dhyan Kusuma

doi:10.3390/scipharm85010014

Cited by 25 publications

(18 citation statements)

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this case, computational drug discovery tools have been used for observing and analyzing the active compounds of Indonesian medicinal plants used for treating TB. Some studies showed that natural compounds from indigenous Indonesian medicinal plants could inhibit the incidence of TB infection by balancing immunity system and eradicating mycobacteria [17][18][19][20].…”

Section: Computational Studies Of Active Compound Of Indonesian Herbamentioning

confidence: 99%

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

Widyarti¹,

Kamaruddin²,

Aristyani³

et al. 2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

View full text Add to dashboard Cite

Tuberculosis (TB) is one of the leading infectious diseases in the world. The disease is commonly caused by Mycobacterium tuberculosis (Mtb) bacteria which are capable of rapidly spreading through droplet transmission. In developing countries, poverty and malnutrition cause immunodeficiency which is considered as the main risk factor for the incidence of TB. Treatment of TB has been proven to be difficult because treatment options are very limited and found to be expensive specifically in developing countries. Moreover, the existence of extensively drug-resistant TB phenomena is frequently happening in these countries because of mishandling treatments used for this disease. In Indonesia, the traditional herbal medicine, namely, jamu, has been utilized since a long time ago to treat diseases including TB. The present study by using computational methods found that there are many active compounds that can bound and influence proteins responsible for TB pathogenesis. Besides, these compounds have the potency to modulate the host immune system. The current chapter discussed the possible interaction of the antioxidant compounds with the chelating potential to form a complex with transitional metal as the central atom. In the perspective of bioinorganic chemistry, this complex has a scavenging activity which is expected to have a role in overcoming energy management of the host cell during infection pathogenesis. It is important to involve bioinorganic chemistry in energy management during infection, correlated with impairing of niacin metabolism of the host cell in which the host cell mitochondria cannot competitively gain free radicals during infection. This phenomenon is the main reason to propose herbal medicine as a source of niacin and provide a proper environment for gastrointestinal commensal microbiota to treat and govern protection from TB infection.

show abstract

Section: Computational Studies Of Active Compound Of Indonesian Herbamentioning

confidence: 99%

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

Widyarti¹,

Kamaruddin²,

Aristyani³

et al. 2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

View full text Add to dashboard Cite

show abstract

“…F) Ness), herba pegagan (Centella asiatica), daun beluntas (Pluchea indica) dan kencur (Kaempferia galanga L.). Seluruh herbal tersebut mampu menghambat pertumbuhan M. tuberculosis H37Rv sebesar 100% pada masing-masing konsentrasi sebagai berikut: herba sambiloto (5 mg/mL), herba pegagan (5 mg/mL), daun beluntas (5 mg/mL) dan kencur (1 mg/mL) [Radji, et al, 2015;Fauziyah PN, et al, 2017]. Teknik pengolahan herbal tersebut dapat dilakukan dengan beberapa tahap yang harus diinformasikan dengan baik dan jelas kepada masyarakat desa Cilayung.…”

Section: Pendahuluanunclassified

“…Jadi dapat disimpulkan, daun beluntas berpotensi kuat sebagai anti tuberkulosis alami. Sedangkan herba pegagan memiliki potensi antituberkulosis yang lebih rendah dibandingkan kedua herba tersebut, pada dosis yang sama, herba pegagan mampu menghambat pertumbuhan M. tuberculosis H37Rv sebesar 78.5% dan 50% terhadap MDR [Radji , et al, 2015].. Rimpang kencur dalam bentuk ekstrak kental dengan dosis 1 mg/ml dibuktikan mampu menghambat pertumbuhan M. tuberculosis H37Rv dan isolat M. tuberculosis yang resisten terhadap Rifampisin-Streptomisin sebesar 100% [Fauziyah PN, et al, 2017].…”

Section: Hasil Dan Pembahasanunclassified

Deteksi Dini Tuberkulosis Sebagai Upaya Pencegahan Penularan Penyakit Tuberkulosis Dan Pengolahan Herbal Antituberkulosis Berbasis Riset

Kusuma¹

2019

Dharmakarya

View full text Add to dashboard Cite

Penegakkan diagnosis tuberkulosis yang cepat dan akurat dapat dijadikan solusi permasalahan keterbatasan metode deteksi tuberkulosis yang mengakibatkan keterlambatan pengobatan tuberkulosis. Tujuan dari kegiatan penyuluhan ini adalah untuk mencegah penularan tuberkulosis melalui peningkatan pengetahuan masyarakat desa Cilayung Jatinangor tentang gejala tuberkulosis secara dini, memupuk kesadaran masyarakat untuk memutuskan rantai penularan melalui pemeriksaan dini dan pengobatan yang cepat dan tepat serta mengenalkan hasil riset berupa herbal anti tuberkulosis yang dapat diolah secara mandiri sebagai pengobatan alami. Kegiatan ini meliputi pengumpulan data informatif pengetahuan masyarakat tentang penyakit tuberkulosis melalui wawancara dan pre-test, dilanjutkan dengan kegiatan penyuluhan, post test, pengenalan herbal antituberkulosis dan teknik pengolahannya. Hasil yang diperoleh adalah didapatkan data tingkat pengetahuan masyarakat desa Cilayung tentang penyakit tuberkulosis dan pengenalan gejala tuberkulosis secara dini yaitu sebanyak 6.67% berpengetahuan baik, 23.3% berpengetahuan cukup, dan 70% berpengetahuan kurang. Jadi dapat disimpulkan bahwa setelah diadakan penyuluhan, tingkat pengetahuan warga meningkat menjadi 16,67% berpengetahuan baik, 56,67% berpengetahuan cukup, dan 26,67% berpengetahuan kurang. Pengenalan dan teknik pengolahan herbal antituberkulosis yaitu herba sambiloto (Andrographis paniculata (Burm. F) Ness), herba pegagan (Centella asiatica), daun beluntas (Pluchea indica) dan rimpang kencur (Kaempferia galanga L.) dalam bentuk sediaan minuman, berupa teh celup dan serbuk instan, dapat memberikan variasi bentuk herbal yang dikonsumsi, selain dengan teknik perebusan yang selama ini dilakukan masyarakat Cilayung.

show abstract

“…65 The extracts of Andrographis paniculata, Petiveria alliacea, Morinda citrifolia, Acorus calamus L.,Aloe vera, Kaempferia galanga L., and Syzygium cumini (L.) Skeels were also reported that had the ability to suppress the activity of Mycobacterium tuberculosis. [66][67][68][69][70][71]…”

Section: Plants Used For Treating Tuberculosis In Indonesia Provincesmentioning

confidence: 99%

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Aristyani¹,

Widyarti²,

Sumitro³

2018

View full text Add to dashboard Cite

Background: Indonesia is the biggest archipelago country with the second biggest biodiversity in the world. A lot of medical plants for treating various diseases can be found in Indonesia, including medical plants for tuberculosis, an infectious disease caused by Mycobacterium tuberculosis. Objective: The goal of this research is to document the information of Indonesia indigenous medical plants that used various local societies to treat tuberculosis and also analyze active compounds of medical plants with proteins that related to tuberculosis. Methods and Materials: The annotation of medical plants for treating tuberculosis was collected from a various source comprising local research papers, theses, and other resources. The information of active compound was taken from Dr. Duke's Phytochemical and Ethnobotanical Databases. A network of active compounds-proteins was analyzed by using Cytoscape 3.6.0. Results: The result described that there were twenty-seven species from nineteen families of medical plants used by local societies of Indonesia for tuberculosis therapy, and there were sundry of active compounds from fourteen medical plants had direct interaction with proteins related tuberculosis. Conclusion: Most of the active compounds targeted proteins that had a prominent role in immune system. It indicated that medical plants treating tuberculosis through regulating immunity of human body. ABSTRACT SUMMARY • Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis. For a long time, Indonesia local societies have been used medical plants for tuberculosis therapy. By using network analysis study, the active compounds of medical plants can modulate human immunity to treat tuberculosis. Sherry Aristyani, a master student of Biology in Faculty of Mathematics and Natural Sciences, University of Brawijaya. Her master research focuses on active compounds of Indonesia medical plants for tuberculosis therapy. Sri Widyarti, Lecturer and researcher in Faculty of Mathematics and Natural Sciences, University of Brawijaya. She has expertise in biology cell. Sutiman Bambang Sumitro, a professor in Department of Biology, Faculty of Mathematics and Natural Sciences, University of Brawijaya. He has expertise in biology cell, bioinorganic, and nano-biology. ABOUT AUTHORS

show abstract

Combination Effect of Antituberculosis Drugs and Ethanolic Extract of Selected Medicinal Plants against Multi-Drug Resistant Mycobacterium tuberculosis Isolates

Cited by 25 publications

References 9 publications

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

Deteksi Dini Tuberkulosis Sebagai Upaya Pencegahan Penularan Penyakit Tuberkulosis Dan Pengolahan Herbal Antituberkulosis Berbasis Riset

Network Analysis of Indigenous Indonesia Medical Plants for Treating Tuberculosis

Contact Info

Product

Resources

About