Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial

SUMMARYThe authors study a patient carrying Aids, with exuberant dermatological manifestations of cryptococcosis. They stress the therapeutic effectiveness of short-term amphotericin B. The authors reviewed cases of cutaneous infection with Cryptococcus reported in the national and international literature, verifying that the frequency has increased with the AIDS epidemic. Also, they discuss about the differential diagnosis with some cases of dermatosis, particularly with the disseminated giant molluscum contagiosum. In relation to the therapy, they affirm that the choice of drug depends on the organ involved, as well as the immune state of the patient.

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“…The advantages of the latter are its administration through the mouth and the lesser frequency of collateral effects 4,25,30,32 .…”

Section: Resultsmentioning

confidence: 99%

Disseminated cutaneous cryptococcosis in a patient with AIDS

Dinato

Dinato²,

Nakanishi³

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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“…In terms of antifungal therapy, the combination of amphotericin and flucytosine is accepted as being the most rapid fungicidal therapeutic regimen in the initial 2 weeks of treatment [16]. The goal is to achieve sterilization of the CSF.…”

Section: Discussionmentioning

confidence: 99%

Cryptococcus gattii Meningoencephalitis in an Immunocompetent Person 13 Months after Exposure

et al. 2009

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A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.

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“…nie dorównuje skutecznością terapii skojarzonej amfoterycyną i flucytozyną [17][18][19][20]. Najmniej skuteczna jest monoterapia flukonazolem -stwierdzono o 30% wyższą śmier-telność w 10. tygodniu leczenia w porównaniu z leczeniem opartym na amfoterycynie [21].…”

Section: Leczenie CMunclassified

Kryptokowe zapalenie opon mózgowych i mózgu u pacjentów zakażonych HIV

Kozłowska¹

2016

Forum Zakażeń

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Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial

Cited by 434 publications

References 8 publications

Disseminated cutaneous cryptococcosis in a patient with AIDS

Disseminated cutaneous cryptococcosis in a patient with AIDS

Cryptococcus gattii Meningoencephalitis in an Immunocompetent Person 13 Months after Exposure

Kryptokowe zapalenie opon mózgowych i mózgu u pacjentów zakażonych HIV

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