Disseminated cutaneous cryptococcosis in a patient with AIDS

Abstract

SUMMARYThe authors study a patient carrying Aids, with exuberant dermatological manifestations of cryptococcosis. They stress the therapeutic effectiveness of short-term amphotericin B. The authors reviewed cases of cutaneous infection with Cryptococcus reported in the national and international literature, verifying that the frequency has increased with the AIDS epidemic. Also, they discuss about the differential diagnosis with some cases of dermatosis, particularly with the disseminated giant molluscum contagiosum. In relation to the therapy, they affirm that the choice of drug depends on the organ involved, as well as the immune state of the patient.

Disseminated cryptococcosis and fluconazole resistant oral candidiasis in a patient with acquired immunodeficiency syndrome (AIDS)

“…However, in this patient, there were no granulomatous reactions or inflammatory responses seen in any tissue sections; instead, there were extensive disseminated gelatinous-appearing lesions and large number of encapsulated yeasts. Comparable findings are seen in other full-blown AIDS patients as well [6,7,8].…”

Cryptococcal Epidural Abscess With Bone Involvement

“…Cases were distributed almost equally among males 4 versus female. 3 Most patients 5 presented with a painless scalp swelling, and less than half 3 had associated headache. The most common site of infection was parietal area 3 followed by frontal area 2 and temporoparietal area.…”

“…1,2 Cryptococcus is a ubiquitous fungus commonly found in the soil and in animal secretions such as pigeon excreta. 3 Although primarily associated with immunocompromised hosts with human immunodeficiency virus, sarcoid, lymphoma, long-term corticosteroid use, organ transplantation, or malignancy, it has been implicated as a pathogen in immunocompetent patients as well. 4Y8 …”

Avaliação de seqüências iniciadoras das regiões 18SrDNA, 5,8SrDNA e ITS pela Nested PCR, em amostras de soro e líquor de pacientes com síndrome da imunodeficiência adquirida (SIDA) para o diagnóstico molecular da criptococose

“…Entretanto em indivíduos com SIDA as lesões de criptococose cutânea, geralmente são reconhecidas como infecções secundárias ao acometimento sistêmico, ocorrendo em 10% dos casos (Etxaburu et al, 1996;Tapiz et al, 1996;Dinato et al, 2006 (Pappalardo, Melhem, 2003 Perfect, 1995b;Casadevall, Perfect, 1998).…”

“…The following up of AIDS patients, throughout the course of therapy was found to be feasible, accurate and less invasive to detect C. neoformans by using serum samples (directly). (Giorgi et al, 1974;Kwon-Chung, 1992;Perfect, Casadevall, 2002;Dinato et al, 2006).…”