Combatting antibiotic-resistant bacteria using nanomaterials

Gupta, Akash; Mumtaz, Shazia; Li, Cheng‐Hsuan; Hussain, Irshad; Rotello, Vincent M.

doi:10.1039/c7cs00748e

Cited by 731 publications

(515 citation statements)

References 49 publications

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“…Very few examples are reported of antibiotics conjugated with general delivery systems, such as CPPs, and the improvement in antibacterial activity against Gram‐negative bacteria was minor . Larger delivery systems like nanoparticles, dendrimers, vesicles, or carbon nanotubes have also been investigated …”

Section: Figurementioning

confidence: 99%

Probing for Thiol‐Mediated Uptake into Bacteria

et al. 2019

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Cellular uptake mediated by cyclic oligochalcogenides (COCs) is emerging as a conceptually innovative method to penetrate mammalian cells. Their mode of action is based on dynamic covalent oligochalcogenide exchange with cellular thiols. To test thiol‐mediated uptake in bacteria, five antibiotics have been equipped with up to three different COCs: One diselenolane and two dithiolanes. We found that the COCs do not activate antibiotics in Gram‐negative bacteria. In Gram‐positive bacteria, the COCs inactivate antibiotics that act in the cytoplasm and reduce the activity of antibiotics that act on the cell surface. These results indicate that thiol‐mediated uptake operates in neither of the membranes of bacteria. COCs are likely to exchange with thiols on the inner, maybe also on the outer membrane, but do not move on. Concerning mammalian cells, the absence of a COC‐mediated uptake into bacteria observed in this study disfavors trivial mechanisms, such as passive diffusion, and supports the existence of more sophisticated, so far poorly understood uptake pathways.

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Section: Figurementioning

confidence: 99%

Probing for Thiol‐Mediated Uptake into Bacteria

et al. 2019

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“…In recent decades, NPs have drawn significant attention in biomedicine because of their extensive applications in drug delivery systems, contrast agents, diagnostic tools and antennas for photothermal therapy . The formation of NPs can be roughly divided into three stages: nucleation, growth and agglomeration .…”

Section: Microfluidic Generation Of Npsmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

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As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

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“…This fact makes S. aureus one of the most formidable pathogens. In view of its high infection opportunity, particularly for the hospitalized patients, new types of antibacterial agents or therapies not easy to elicit resistance are urgently and desperately needed for disinfection of S. aureus …”

Section: Figurementioning

confidence: 99%

Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged Ru^II Complexes

Yang

Sun

Wang

et al. 2019

Chemistry A European J

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Ruthenium(II) polypyridyl complexes featuring peripheral quaternary ammonium structures were found to be able to selectively inactivate Gram‐positive Staphylococcus aureus (S. aureus), including methicillin‐resistant S. aureus (MRSA) upon visible light irradiation, but have low phototoxicity toward 293T cells, L02 cells and lack hemolysis toward rabbit red blood cells (RBC), exhibiting promising potential as a novel type of antimicrobial photodynamic therapy (aPDT) agents.

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Combatting antibiotic-resistant bacteria using nanomaterials

Abstract: Nanomaterials as self-therapeutic agents and drug-delivery vehicles for antimicrobial therapies.

Cited by 731 publications

References 49 publications

Probing for Thiol‐Mediated Uptake into Bacteria

Probing for Thiol‐Mediated Uptake into Bacteria

Microfluidic Generation of Nanomaterials for Biomedical Applications

Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged Ru^II Complexes

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Combatting antibiotic-resistant bacteria using nanomaterials

Abstract: Nanomaterials as self-therapeutic agents and drug-delivery vehicles for antimicrobial therapies.

Cited by 731 publications

References 49 publications

Probing for Thiol‐Mediated Uptake into Bacteria

Probing for Thiol‐Mediated Uptake into Bacteria

Microfluidic Generation of Nanomaterials for Biomedical Applications

Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged RuII Complexes

Contact Info

Product

Resources

About

Selective Photoinactivation of Methicillin‐Resistant Staphylococcus aureus by Highly Positively Charged Ru^II Complexes